Editorial: Diversifying clinical trials

Latest Research

  • Resource |

    An integrated analysis of glioma samples from patients with neurofibromatosis 1 annotates their mutational, epigenetic, transcriptional, and immunological features and uncovers similitudes with a subset of sporadic gliomas.

    • Fulvio D’Angelo
    • , Michele Ceccarelli
    • , Tala
    • , Luciano Garofano
    • , Jing Zhang
    • , Véronique Frattini
    • , Francesca P. Caruso
    • , Genevieve Lewis
    • , Kristin D. Alfaro
    • , Luc Bauchet
    • , Giulia Berzero
    • , David Cachia
    • , Mario Cangiano
    • , Laurent Capelle
    • , John de Groot
    • , Francesco DiMeco
    • , François Ducray
    • , Walid Farah
    • , Gaetano Finocchiaro
    • , Stéphane Goutagny
    • , Carlos Kamiya-Matsuoka
    • , Cinzia Lavarino
    • , Hugues Loiseau
    • , Véronique Lorgis
    • , Carlo E. Marras
    • , Ian McCutcheon
    • , Do-Hyun Nam
    • , Susanna Ronchi
    • , Veronica Saletti
    • , Romuald Seizeur
    • , John Slopis
    • , Mariona Suñol
    • , Fanny Vandenbos
    • , Pascale Varlet
    • , Dominique Vidaud
    • , Colin Watts
    • , Viviane Tabar
    • , David E. Reuss
    • , Seung-Ki Kim
    • , David Meyronet
    • , Karima Mokhtari
    • , Hector Salvador
    • , Krishna P. Bhat
    • , Marica Eoli
    • , Marc Sanson
    • , Anna Lasorella
    •  & Antonio Iavarone
  • Article |

    Single cell dissection of plasma cell heterogeneity in myeloma patients reveals new insights into disease that may inform early diagnosis and clinical management.

    • Guy Ledergor
    • , Assaf Weiner
    • , Mor Zada
    • , Shuang-Yin Wang
    • , Yael C. Cohen
    • , Moshe E. Gatt
    • , Nimrod Snir
    • , Hila Magen
    • , Maya Koren-Michowitz
    • , Katrin Herzog-Tzarfati
    • , Hadas Keren-Shaul
    • , Chamutal Bornstein
    • , Ron Rotkopf
    • , Ido Yofe
    • , Eyal David
    • , Venkata Yellapantula
    • , Sigalit Kay
    • , Moshe Salai
    • , Dina Ben Yehuda
    • , Arnon Nagler
    • , Lev Shvidel
    • , Avi Orr-Urtreger
    • , Keren Bahar Halpern
    • , Shalev Itzkovitz
    • , Ola Landgren
    • , Jesus San-Miguel
    • , Bruno Paiva
    • , Jonathan J. Keats
    • , Elli Papaemmanuil
    • , Irit Avivi
    • , Gabriel I. Barbash
    • , Amos Tanay
    •  & Ido Amit
  • Letter |

    Intratumoral T cells that are capable of recognizing adjacent tumor tissue antigens can be exceedingly rare.

    • Wouter Scheper
    • , Sander Kelderman
    • , Lorenzo F. Fanchi
    • , Carsten Linnemann
    • , Gavin Bendle
    • , Marije A. J. de Rooij
    • , Christian Hirt
    • , Riccardo Mezzadra
    • , Maarten Slagter
    • , Krijn Dijkstra
    • , Roelof J. C. Kluin
    • , Petur Snaebjornsson
    • , Katy Milne
    • , Brad H. Nelson
    • , Henry Zijlmans
    • , Gemma Kenter
    • , Emile E. Voest
    • , John B. A. G. Haanen
    •  & Ton N. Schumacher
  • Article |

    Evolutionarily conserved gene modules mediate neurodegenerative dementia in a variety of mouse models and in postmortem brain tissue from patients.

    • Vivek Swarup
    • , Flora I. Hinz
    • , Jessica E. Rexach
    • , Ken-ichi Noguchi
    • , Hiroyoshi Toyoshiba
    • , Akira Oda
    • , Keisuke Hirai
    • , Arjun Sarkar
    • , Nicholas T. Seyfried
    • , Chialin Cheng
    • , Stephen J. Haggarty
    • , Raffaele Ferrari
    • , Jonathan D. Rohrer
    • , Adaikalavan Ramasamy
    • , John Hardy
    • , Dena G. Hernandez
    • , Michael A. Nalls
    • , Andrew B. Singleton
    • , John B. J. Kwok
    • , Carol Dobson-Stone
    • , William S. Brooks
    • , Peter R. Schofield
    • , Glenda M. Halliday
    • , John R. Hodges
    • , Olivier Piguet
    • , Lauren Bartley
    • , Elizabeth Thompson
    • , Eric Haan
    • , Isabel Hernández
    • , Agustín Ruiz
    • , Mercè Boada
    • , Barbara Borroni
    • , Alessandro Padovani
    • , Nigel J. Cairns
    • , Carlos Cruchaga
    • , Giuliano Binetti
    • , Roberta Ghidoni
    • , Luisa Benussi
    • , Gianluigi Forloni
    • , Diego Albani
    • , Daniela Galimberti
    • , Chiara Fenoglio
    • , Maria Serpente
    • , Elio Scarpini
    • , Jordi Clarimón
    • , Alberto Lleó
    • , Rafael Blesa
    • , Maria Landqvist Waldö
    • , Karin Nilsson
    • , Christer Nilsson
    • , Ian R. A. Mackenzie
    • , Ging-Yuek R. Hsiung
    • , David M. A. Mann
    • , Jordan Grafman
    • , Christopher M. Morris
    • , Johannes Attems
    • , Timothy D. Griffiths
    • , Ian G. McKeith
    • , Alan J. Thomas
    • , Evelyn Jaros
    • , Pietro Pietrini
    • , Edward D. Huey
    • , Eric M. Wassermann
    • , Michael C. Tierney
    • , Atik Baborie
    • , Pau Pastor
    • , Sara Ortega-Cubero
    • , Cristina Razquin
    • , Elena Alonso
    • , Robert Perneczky
    • , Janine Diehl-Schmid
    • , Panagiotis Alexopoulos
    • , Alexander Kurz
    • , Innocenzo Rainero
    • , Elisa Rubino
    • , Lorenzo Pinessi
    • , Ekaterina Rogaeva
    • , Peter St. George-Hyslop
    • , Giacomina Rossi
    • , Fabrizio Tagliavini
    • , Giorgio Giaccone
    • , James B. Rowe
    • , Johannes C. M. Schlachetzki
    • , James Uphill
    • , John Collinge
    • , Simon Mead
    • , Adrian Danek
    • , Vivianna M. Van Deerlin
    • , Murray Grossman
    • , John Q. Trojanowski
    • , Stuart Pickering-Brown
    • , Parastoo Momeni
    • , Julie van der Zee
    • , Marc Cruts
    • , Christine Van Broeckhoven
    • , Stefano F. Cappa
    • , Isabelle Leber
    • , Alexis Brice
    • , Didier Hannequin
    • , Véronique Golfier
    • , Martine Vercelletto
    • , Benedetta Nacmias
    • , Sandro Sorbi
    • , Silvia Bagnoli
    • , Irene Piaceri
    • , Jørgen E. Nielsen
    • , Lena E. Hjermind
    • , Matthias Riemenschneider
    • , Manuel Mayhaus
    • , Gilles Gasparoni
    • , Sabrina Pichler
    • , Bernd Ibach
    • , Martin N. Rossor
    • , Nick C. Fox
    • , Jason D. Warren
    • , Maria Grazia Spillantini
    • , Huw R. Morris
    • , Patrizia Rizzu
    • , Peter Heutink
    • , Julie S. Snowden
    • , Sara Rollinson
    • , Alexander Gerhard
    • , Anna Richardson
    • , Amalia C. Bruni
    • , Raffaele Maletta
    • , Francesca Frangipane
    • , Chiara Cupidi
    • , Livia Bernardi
    • , Maria Anfossi
    • , Maura Gallo
    • , Maria Elena Conidi
    • , Nicoletta Smirne
    • , Rosa Rademakers
    • , Matt Baker
    • , Dennis W. Dickson
    • , Neill R. Graff-Radford
    • , Ronald C. Petersen
    • , David Knopman
    • , Keith A. Josephs
    • , Bradley F. Boeve
    • , Joseph E. Parisi
    • , Bruce L. Miller
    • , Anna M. Karydas
    • , Howard Rosen
    • , William W. Seeley
    • , John C. van Swieten
    • , Elise G. P. Dopper
    • , Harro Seelaar
    • , Yolande A. L. Pijnenburg
    • , Philip Scheltens
    • , Giancarlo Logroscino
    • , Rosa Capozzo
    • , Valeria Novelli
    • , Annibale A. Puca
    • , Massimo Franceschi
    • , Alfredo Postiglione
    • , Graziella Milan
    • , Paolo Sorrentino
    • , Mark Kristiansen
    • , Huei-Hsin Chiang
    • , Caroline Graff
    • , Florence Pasquier
    • , Adeline Rollin
    • , Vincent Deramecourt
    • , Thibaud Lebouvier
    • , Luigi Ferrucci
    • , Dimitrios Kapogiannis
    • , Murray Grossman
    • , Vivianna M. Van Deerlin
    • , John Q. Trojanowski
    • , James J. Lah
    • , Allan I. Levey
    • , Shinichi Kondou
    •  & Daniel H. Geschwind
  • Letter |

    High-resolution sequencing of longitudinal patient samples reveals subclonal mutational diversity in the stem cell compartment driving parallel evolution patterns in acute myeloid leukemia progression.

    • Jiahao Chen
    • , Yun-Ruei Kao
    • , Daqian Sun
    • , Tihomira I. Todorova
    • , David Reynolds
    • , Swathi-Rao Narayanagari
    • , Cristina Montagna
    • , Britta Will
    • , Amit Verma
    •  & and Ulrich Steidl

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