Volume 9 Issue 9, September 2008


  • Editorial |

    Leukocytes express an array of chemoattractant and adhesion receptors that govern their migration, behavior and survival.



Research Highlights



News and Views

  • News & Views |

    Natural killer T cells acquire their unique phenotype and characteristics during development in the thymus. Evidence suggests that the transcription factor PLZF has a unique function in the development of these cells and their acquisition of 'innate-like' characteristics.

    • Laurent Gapin
  • News & Views |

    Excessive lung inflammation in response to infection or allergens can lead to tissue damage and potentially loss of organ function. The CD200-CD200R interaction acts to limit such destructive immune responses in the lung.

    • Patrick G Holt
    •  & Deborah H Strickland
  • News & Views |

    New findings show that cellular microRNAs 'calibrate' the baseline expression of mRNAs encoding stress-inducible ligands of the activating NKG2D receptor. This regulation serves to protect innocent cells but may be exploited by tumors and viruses to thwart immune attack.

    • Thomas Spies
  • News & Views |

    Definitive new data solidify and clarify the function of the adaptor TRADD in tumor necrosis factor receptor 1 signaling and show that in some situations, TRADD is also required for the transmission of Toll-like receptor signals.

    • Gioacchino Natoli
    •  & Liv M I Austenaa



  • Focus |

    Leukocyte Trafficking

    Immune cells are constantly in motion in surveillance for potential microbial threats. Here we present a collection of reviews that describe the trafficking patterns, cues and means by which immune cells transit tissues in health and in response to infections.