Volume 9 Issue 9, September 2008

Volume 9 Issue 9

Immune cells are constantly on the go. Circulating leukocytes respond to many chemoattractants that direct their exit from the bloodstream and their entrance into and exit from tissues. This month, we present a series of commissioned review articles focusing on the trafficking patterns of migrating immune cells. Additional discussion of relevant ongoing research topics is available online (www.nature.com/ni/focus/trafficking/index.html). Artwork by Lewis Long.


  • Editorial |

    Leukocytes express an array of chemoattractant and adhesion receptors that govern their migration, behavior and survival.



Research Highlights



News and Views

  • News & Views |

    Natural killer T cells acquire their unique phenotype and characteristics during development in the thymus. Evidence suggests that the transcription factor PLZF has a unique function in the development of these cells and their acquisition of 'innate-like' characteristics.

    • Laurent Gapin
  • News & Views |

    Excessive lung inflammation in response to infection or allergens can lead to tissue damage and potentially loss of organ function. The CD200-CD200R interaction acts to limit such destructive immune responses in the lung.

    • Patrick G Holt
    •  & Deborah H Strickland
  • News & Views |

    New findings show that cellular microRNAs 'calibrate' the baseline expression of mRNAs encoding stress-inducible ligands of the activating NKG2D receptor. This regulation serves to protect innocent cells but may be exploited by tumors and viruses to thwart immune attack.

    • Thomas Spies
  • News & Views |

    Definitive new data solidify and clarify the function of the adaptor TRADD in tumor necrosis factor receptor 1 signaling and show that in some situations, TRADD is also required for the transmission of Toll-like receptor signals.

    • Gioacchino Natoli
    •  & Liv M I Austenaa



  • Focus |

    Leukocyte Trafficking

    Immune cells are constantly in motion in surveillance for potential microbial threats. Here we present a collection of reviews that describe the trafficking patterns, cues and means by which immune cells transit tissues in health and in response to infections.