Volume 9 Issue 6, June 2008

Editorial

Essay

  • Essay |

    Harald von Boehmer describes how he used mice transgenic for T cell receptor αβ to identify T cell receptor–dependent cellular selection and lineage commitment as mechanisms responsible for generating an effective and self-tolerant adaptive immune system.

    • Harald von Boehmer

Commentary

  • Commentary |

    The need to translate basic research in the field of human immunology may be much more urgent, and the rewards potentially much greater, than is often acknowledged. Yet a commonly perceived coercion to undertake translational research may be unhelpful. Instead, we propose clear incentives for integrating key skill sets, together with achievable cultural adjustments in research and medicine that span training, recruitment and promotion.

    • Adrian C Hayday
    •  & Mark Peakman

News and Views

  • News & Views |

    Toll-like receptors trigger an innate immune response by activating signaling pathways that are dependent on IRAK kinases. According to Kawagoe et al., the least understood IRAK member, IRAK2, is required for the perpetuation of these signals.

    • Etienne Meylan
    •  & Jürg Tschopp
  • News & Views |

    The T cell receptor (TCR) is functionally coupled to a constellation of ten immunoreceptor tyrosine–based activation motifs (ITAMs). A new study suggests that this large number of ITAMs is mandatory for preventing autoimmunity.

    • Bernard Malissen
  • News & Views |

    A new study finds that local homeostatic expansion of conventional dendritic cells in the spleen is regulated by Fms-related tyrosine kinase-3 ligand.

    • Cedric Auffray
    • , Yalin Emre
    •  & Frederic Geissmann
  • News & Views |

    B cell tolerance is achieved in part through secondary rearrangements that replace ('edit') exons encoding autoreactive antigen-receptor chains. New findings suggest that Foxo transcription factors are critical regulators of receptor editing by activating the transcription of recombination-activating genes.

    • Marta A W Rowh
    •  & Craig H Bassing
  • News & Views |

    Three new studies demonstrate that development of human TH-17 cells requires transforming growth factor-β and one or more proinflammatory cytokines, which are the same requirements as for mouse TH-17 development.

    • Anne O'Garra
    • , Brigitta Stockinger
    •  & Marc Veldhoen

Review

Articles

Corrigendum