Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 9 Issue 5, May 2008

In response to viruses, plasmacytoid dendritic cells (pDCs) produce interferon-α. Connolly and colleagues (p. 551; News and Views by Pulendran, p. 461) show that pDCs also rapidly internalize exogenous viral antigens and present them on major histocompatibility complex class I to CD8+ T cells. The original image shows the pDC major histocompatibility complex class I compartment (red), nuclei (blue) and actin (green). Original image by Sandra Clayton. Artwork by Lewis Long.

Volume 9 Issue 5

Subscribe

Editorial

  • Responding to escalating violence by extremist animal-rights groups, academics are working proactively to prevent the harassment and harm of scientists.

    Editorial

    Advertisement

Top of page ⤴

Meeting Report

  • Every 2 years, scientists interested in immunomodulation meet to discuss new opportunities arising from interactions between basic science and clinical 'translation'. This report discusses the 8th International Conference on New Trends in Immunosuppression and Immunotherapy, 2008, in Berlin.

    • Birgit Sawitzki
    • Petra Reinke
    • Laurence A Turka
    Meeting Report
Top of page ⤴

News & Views

  • The intensity of cytokine-induced signaling by the kinase PI(3)K subunit p110δ proves to be an important regulator of T cell migration patterns. High PI(3)K activity functions through the nutrient and bioenergetic sensor mTOR to modulate the transcription factor KLF2 and thereby the repertoire of tissue-homing receptors expressed on effector T cells.

    • Gabriel Berstein
    • Robert T Abraham
    News & Views

  • How engagement of surface T cell antigen receptors 'translates' into intracellular signal cascades remains vague. Genetic and biochemical experiments now allow modification of a model linking ligation of these receptors with CD3ɛ and other cytoplasmic signal-transduction 'machinery'.

    • Jonathan S Maltzman
    • Gary A Koretzky
    News & Views

  • Toll-like receptor signaling induces the production of proinflammatory cytokines and type I interferons. Inhibition of the kinase IRAK1 by the phosphatase SHP-1 provides reciprocal regulation of these pathways by dampening the former while enhancing the latter.

    • Luke A J O'Neill
    News & Views

  • Cross-presentation of antigens is essential for the responses of cytotoxic T cells to tumors and viruses. Two new papers offer insights into the subcellular compartment and types of dendritic cells that mediate cross-presentation.

    • Sudhir Pai Kasturi
    • Bali Pulendran
    News & Views
Top of page ⤴

Editorial

  • This Focus on natural killer cells aims to highlight what is currently known and what remains to be understood about these important innate immune cells.

    Editorial
Top of page ⤴

Overview

Top of page ⤴

Essay

  • The idea that NK cells can distinguish aberrant cells by recognizing 'absence of the expected', rather than 'presence of the unexpected' emerged more than 25 years ago. Klas Kärre recapitulates how the idea took shape, and the first five years of experimental work to test its general predictions.

    • Klas Kärre
    Essay
Top of page ⤴

Perspective

Top of page ⤴

Review Article

Top of page ⤴

Research Highlights

Top of page ⤴

Article

Top of page ⤴

Corrigendum

Top of page ⤴

Focus

  • An overview, two review articles, two perspective articles and one personal essay discuss the differentiation, responsiveness and biological functions of natural killer cells.

    Focus
Top of page ⤴

Search

Advanced search

Quick links