Volume 9 Issue 4, April 2008

Editorials

  • Editorial |

    New accession codes and links pack even more information into Nature Immunology research articles

  • Editorial |

    Hearing about past and present issues in the world community of immunology can enrich all of us.

Obituary

Essay

Commentary

  • Commentary |

    Over the past decade immunological research in China has developed rapidly. This commentary describes the history, summarizes the present research funding system, institutions and representative work, and discusses the future of immunological research in China.

    • Xuetao Cao

News and Views

  • News & Views |

    TLR4 somehow manages to activate both MyD88- and TRIF-dependent signaling. According to Medzhitov and colleagues, TLR4 engages MyD88 and TRIF sequentially at the cell surface and in endosomes, respectively, thereby providing access to distinct pools of signaling proteins.

    • Colin Watts
  • News & Views |

    The bone marrow contains specialized microenvironments that maintain blood cells and supply the requisite factors for their development. Newly identified bone marrow–resident dendritic cells create unique niches for mature B cells.

    • Takashi Nagasawa
  • News & Views |

    The homing of lymphocytes to secondary lymphoid organs occurs at specialized blood vessels, the high endothelial venules. Autotaxin, a phospholipid-producing enzyme secreted by high endothelial venule endothelium, is a new participant found to facilitate the entry of lymphocytes into secondary lymphoid organs.

    • Dietmar Vestweber
    •  & Martin K Wild
  • News & Views |

    Activation of the transcription factor NF-κB by Toll-like receptors must be controlled to avoid excessive inflammation. The tripartite-motif protein family member TRIM30α has now been shown to mediate a negative regulatory feedback mechanism curtailing such responses.

    • Andrew G Bowie

Review

Articles