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Volume 9 Issue 1, January 2008

Whether type I and type II interleukin 4 receptors exert distinct functions in vivo is not known. Using a mouse lacking the type II interleukin 4 receptor component IL-13Rα1, Wynn and colleagues delineate unique functions of this receptor in vivo (p 25). The original image (bottom) captured under polarized light shows diminished collagen content in the liver of an IL-13Rα1-deficient mouse infected with Schistosoma mansoni. Artwork by Lewis Long.

Volume 9 Issue 1

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  • Picking up where pharmaceutical companies have left off, new academic science coalitions are using innovative techniques to hunt for new antibiotics.

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  • Over 20 years have passed since the discovery of NF-κB and its signaling pathways, yet additional participants continue to be identified. The highly conserved protein Akirin is such an example.

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  • The cytokines IFN-γ and IL-12, along with the transcription factors STAT4 and T-bet, are necessary for driving TH1 development. Fresh data now indicate that the transcription factor IRF1 is also essential in this process.

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  • Splenic marginal zone B cells take up blood-borne antigens. These B cells are now reported to continuously transport antigens to the follicles, a process that ensures efficient delivery of blood-borne antigens to follicular dendritic cells.

    • Georg Kraal
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  • Phagocytosis of apoptotic cells by macrophages occurs through recognition of specific molecules on the surfaces of apoptotic cells by receptors on macrophages. Three recent studies add to the understanding of this process.

    • David A Hume
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