Volume 9 Issue 12, December 2008

Volume 9 Issue 12

Several new functions have been assigned to basophils, including involvement in promoting T helper type 2 immunity. Booki Min (p 1333) reviews the recent literature on basophils analyzing what they 'can do' in vitro and what they 'actually do' during in vivo immune responses. Artwork by Lewis Long.

Editorial

Commentary

  • Commentary |

    Although immunological research is of only recent origin in India, it is nevertheless rapidly becoming an area of choice for young researchers in this country.

    • Kanury V S Rao

News and Views

  • News & Views |

    T cells are intrinsically more malleable than previously thought. Two studies now show that existing T helper type 2 cells can be converted into alternative CD4+ T helper cells that coexpress interleukins 9 and 10.

    • Cristina M Tato
    •  & Daniel J Cua
  • News & Views |

    The protein kinase NIK is regulated by a complex of ubiquitin ligases that destroys it. When NIK-activating receptors are triggered, the ubiquitin ligase complex self-destructs.

    • David Wallach
    •  & Andrew Kovalenko
  • News & Views |

    The function of gene expression in the response of drosophila to viral infection is poorly understood. A report now demonstrates that the helicase Dicer-2 controls antiviral gene expression in addition to RNA interference–mediated gene silencing.

    • Osamu Takeuchi
    •  & Shizuo Akira
  • News & Views |

    The molecular mechanisms by which the nervous system influences innate immunity to pathogens remain mysterious. Two new studies show that neuronal products modulate established innate immune signaling pathways operative in the Caenorhabditis elegans intestine.

    • Cheng-Yuan Kao
    • , Ferdinand C O Los
    •  & Raffi V Aroian

Review

Articles