Volume 9 Issue 11, November 2008

Volume 9 Issue 11

Like stamens protruding from flowers, phosphorylated serine residues protrude from phosphopeptides presented by HLA-A2 molecules. Engelhard and colleagues (p 1236) suggest that the greater HLA-A2- binding affinity afforded by these phosphorylated residues allows phosphopeptides bearing suboptimal 'anchor' residues to interact with HLA-A2 molecules through an unorthodox binding mode. Artwork by Lewis Long.


  • Editorial |

    Turmoil in the world financial markets has forced big government spending to relieve the crisis—but at what cost?

  • Editorial |

    The Large Hadron Collider exemplifies big, bold science that can bring great breakthroughs and, perhaps equally importantly, inspire the public's sense of purpose and possibility.


  • Commentary |

    The work of epidemiologists before the isolation of human immunodeficiency virus 25 years ago demonstrates the power of the epidemiological method to gain an understanding of disease pathogenesis.

    • Harold W Jaffe

News and Views

  • News & Views |

    Cancer cells are more resistant to complement-mediated lysis and use this attribute to set up a locally immunosuppressive environment. However, new findings suggest that tumor-driven complement activation can also provide the tumor a growth advantage.

    • Bruce E Loveland
    •  & Jonathan Cebon
  • News & Views |

    A flurry of studies has suggested the importance of the actin regulator coronin 1A in lymphocyte development. Now, mutants of this regulator are shown to cause immunodeficiency in both mice and humans.

    • Kristin A Hogquist
  • News & Views |

    Major histocompatibility complex class II molecules present peptides to CD4+ T cells. New findings indicate that conventional and plasmacytoid dendritic cells handle these molecules differently after activation.

    • Tineke van den Hoorn
    •  & Jacques Neefjes