Volume 9 Issue 10, October 2008

Volume 9 Issue 10

Like locks moving boats along an upward-sloping canal, transcription factors propel thymocytes through various stages of T cell development. Three papers in this issue (pp 1113, 1122 and 1131; see also News and Views, p 1095) suggest that GATA-3 is needed for initial specification to the CD4+ lineage, whereas ThPOK, by suppressing Runx activity and by maintaining expression of ThPOK and CD4, acts later to prevent diversion toward a CD8+ cell fate. Artwork by Lewis Long.

Editorial

  • Editorial |

    The sometimes arduous effort that went toward securing and distributing state government funds for broader stem cell work should be lauded, not lamented.

Commentaries

  • Commentary |

    • Tracy S P Heng
    • , Michio W Painter
    • , The Immunological Genome Project Consortium
    • , Kutlu Elpek
    • , Veronika Lukacs-Kornek
    • , Nora Mauermann
    • , Shannon J Turley
    • , Daphne Koller
    • , Francis S Kim
    • , Amy J Wagers
    • , Natasha Asinovski
    • , Scott Davis
    • , Marlys Fassett
    • , Markus Feuerer
    • , Daniel H D Gray
    • , Sokol Haxhinasto
    • , Jonathan A Hill
    • , Gordon Hyatt
    • , Catherine Laplace
    • , Kristen Leatherbee
    • , Diane Mathis
    • , Christophe Benoist
    • , Radu Jianu
    • , David H Laidlaw
    • , J Adam Best
    • , Jamie Knell
    • , Ananda W Goldrath
    • , Jessica Jarjoura
    • , Joseph C Sun
    • , Yanan Zhu
    • , Lewis L Lanier
    • , Ayla Ergun
    • , Zheng Li
    • , James J Collins
    • , Susan A Shinton
    • , Richard R Hardy
    • , Randall Friedline
    • , Katelyn Sylvia
    •  & Joonsoo Kang

News and Views

  • News & Views |

    ThPOK is necessary for the differentiation of CD4+ helper T cells. Three new studies indicate that, unexpectedly, ThPOK is required only after initial specification to the CD4+ lineage.

    • J Jeremiah Bell
    •  & Avinash Bhandoola
  • News & Views |

    The production of type I interferon—the first line of defense against virus infection and critical for innate immunity—in plasmacytoid dendritic cells relies on the mammalian target of rapamycin.

    • Mauro Costa-Mattioli
    •  & Nahum Sonenberg
  • News & Views |

    The mechanisms that lead to inflammation after necrotic cell death are poorly understood. New data show that the C-type lectin Mincle is involved in this process.

    • Gordon D Brown
  • News & Views |

    Mycobacterium tuberculosis grows in macrophages but escapes these cells by triggering their death. New findings delineate how this pathogen controls macrophage death to favor bacterial survival and avoid host immunity.

    • Steven A Porcelli
    •  & William R Jacobs Jr

Review

Articles

Corrigendum