Volume 6 Issue 9, September 2005

Volume 6 Issue 9

Notch signaling is required during β-selection. Ciofani and Zúñiga-Pflücker (p 881) demonstrate that Notch signaling regulates cellular metabolism, allowing the energy-intensive outcomes of β-selection to occur. The image depicts a coculture of preT cells (purple) and OP9-DL1 cells expressing the Notch ligand Delta-like 1. Confocal microscopy by Thomas M. Schmitt. Art work by Lewis Long.




  • Commentary |

    Among the concerns surrounding genetically modified crops has been the possibility of expressing within a plant new proteins that may be allergenic. Using available technology, practical approaches have been adopted to help prevent the creation of foods that are allergenic.

    • Dean D Metcalfe

News and Views

  • News & Views |

    Entry of leukocytes into tissues is a key feature of inflammation. New data suggest the polysaccharide heparan sulfate is required for several stages of this entry process.

    • Christopher R Parish
  • News & Views |

    Insects are capable of fighting viral infection even though they do not have B and T cells. Genetic analysis of drosophila C virus infection provides a glimpse of this unexplored area of innate immunity.

    • Y Tony Ip
  • News & Views |

    Fcγ receptor–mediated phagocytosis requires Rac and Cdc42 GTPases. New data show that CAPRI, a GTPase-activating protein for Ras, functions as an adaptor for Rac and Cdc42 during phagocytosis and early phases of bacterial immunity.

    • Steven Greenberg
  • News & Views |

    Lymphocytes continuously recirculate throughout the body. Evidence now suggests chemokine receptor CCR7 actively controls lymphocyte entry into afferent lymphatic vessels.

    • Sergio A Lira
  • News & Views |

    Physiological tolerance of natural killer (NK) cells to self tissues is believed to require the expression of at least one inhibitory receptor specific for self MHC. This dogma may require revision with the identification of self-tolerant NK cells lacking self MHC–specific receptors.

    • H Robson MacDonald