Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Airborne pollution from motor vehicles and industries is a serious threat to human health. Starting from this month and throughout 2005, Nature Immunology examines the contribution of the environment and our modern lifestyle to the increasing prevalence of allergy. In this issue, Saxon and Diaz-Sanchez (p.223) discuss the potential effects of pollution. Artwork by Lewis Long.
How does air pollution affect asthma and allergic rhinitis? Particulate and gaseous pollution drive proallergic inflammation through the generation of oxidative stress, which is regulated by individual genetic susceptibility.
Gene reassortment confers immunoglobulin diversity. Functional diversity occurs by use of distinct heavy chains. Identification of a previously unknown immunoglobulin gene in zebrafish suggests such functional specialization also occurs in this species and probably in all bony fish.
A new study uses experimental infection of naive macaques with simian immunodeficiency virus containing known cytotoxic T lymphocyte escape mutations to examine the host and viral forces governing reversion or persistence of escape during transmission between hosts.
Self-renewal of hematopoietic stem cells allows life-long production of blood cells. Notch signaling is critically involved in this process by maintaining a pool of self-renewing hematopoietic stem cells.