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Volume 6 Issue 12, December 2005

Image depicting the four cardinal signs of inflammation - redness, heat, swelling and pain - originally described by the Roman Aulus Cornelius Celsus in the first century AD. This month we focus on how inflammation is resolved in a series of specially commissioned review articles. These articles and additional features are available free online (www.nature.com.ni/focus/inflammation/index.html) during December 2005. Artwork by Lewis Long.

Volume 6 Issue 12

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Editorial

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Overview

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Review Article

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Research Highlights

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Meeting Report

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News & Views

  • The accumulation of eosinophils in lung tissue, an invariant feature of allergic asthma, requires autocrine production of the cytokine GM-CSF. New data suggest protein isomerization mediated by the enzyme Pin1 is key to the stability of GM-CSF mRNA and eosinophil survival.

    • Paul Anderson
    News & Views

  • The elementary molecular structure responsible for initiating T cell receptor signaling is unknown. Distinct microclusters of a few tens of molecules may accomplish this.

    • Alain Trautmann
    News & Views

  • Lymphocyte egress from lymph nodes is thought to require signals on T cells for the initiation of exit movement. Another possibility is that signaling instead opens endothelial 'gates' through which lymphocytes pass.

    • Klaus Ley
    • Maggie Morris
    News & Views
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Research Highlights

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Article

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Focus

  • A comprehensive overview, and three review articles examine how inflammation is dampened by the immune system.

    Focus
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