Volume 5 Issue 1, January 2004

Volume 5 Issue 1

Lymphatic vessels (green) collect excess fluid and macromolecules from tissues, while simultaneously functioning as an immunological sentinel network. Alitalo and colleagues report on pages 74-80 that VEGF-C is essential in the first steps of embryonic lymphatic development. See also the News and Views by Folkman and Kaipainen. Blood capillaries are stained red; image by T. Tammela.




  • Commentary |

    Dendritic cell–based vaccines have been rapidly transferred from the laboratory to the clinic. As the full potential of these cells has not yet been entirely exploited, many strategies could improve the immunogenicity of these vaccines.

    • Vincenzo Cerundolo
    • , Ian F Hermans
    •  & Mariolina Salio

News and Views

  • News & Views |

    Lymphatic and vascular vessel formation develop in response to specific cues. With the identification of key factors responsible for these interactions, new therapies for the treatment of lymphatic disorders might be on the horizon.

    • Judah Folkman
    •  & Arja Kaipainen
  • News & Views |

    Lymphoid tissue inducer (LTi) cells are central to the development of lymphoid organs during embryonic development. Only these cells express the nuclear receptor RORγt, which turns out to be indispensable for LTi cell survival and function.

    • Martin Lipp
    •  & Gerd Müller
  • News & Views |

    How do commensal gut bacteria coexist with the host without causing uncontrolled inflammation? The answer may lie in the induction of the association of PPAR-γ with NF-κB.

    • Amer A Beg
  • News & Views |

    The immune system uses many sensors to detect and report microbial invaders. Most of these sensors are associated with immune cells, but the extracellular matrix also seems to be essential for this sentinel duty.

    • Christine McDonald
    •  & Gabriel Nuñez
  • News & Views |

    Murr1, a protein linked to copper homeostasis, is shown in a recent Nature paper to inhibit the degradation of IκBα. This unexpected action of Murr1, which blunts both basal and stimulus-coupled activation of the NF-κB transcription factor, is key in making resting CD4 T lymphocytes nonpermissive for HIV infection.

    • Warner C Greene