Volume 5 Issue 12, December 2004

Volume 5 Issue 12

An artistic rendition of a hematopoietic stem cell (lower rectangle) giving rise to two separate lineages of dendritic cells (DCs; circular objects). The resulting plasmacytoid (left) or myeloid (right) DCs have distinct phenotypes and functions. Oldstone and colleagues (p 1227; News and Views by Trinchieri and O'Garra, p 1206) challenge the view that the two DC subsets are truly committed cell lineages by showing that viral infection of bone marrow-derived plasmacytoid DCs converts them (thin white line) into myeloid DCs. Artwork by Lewis Long.




  • Commentary |

    The present shortage in the US influenza vaccine supply has finally focused public attention on recurrent problems faced by public health officials in ensuring the availability of many vaccines.

    • Gregory A Poland
    •  & Edgar K Marcuse

News and Views

  • News & Views |

    The one lymphocyte–one receptor idea is challenged by the recent finding of B cells capable of producing two functional immunoglobulin molecules. Such cells that survive selection might potentially contribute to autoimmunity.

    • Fritz Melchers
  • News & Views |

    The interaction between dendritic cells and T cells is critical for induction of appropriate immune responses. Visualization of their interaction in intact lymph nodes provides insight into the process of generating immunity or tolerance.

    • Antonio Lanzavecchia
    •  & Federica Sallusto
  • News & Views |

    Immunoglobulin class-switch recombination occurs in both frogs and mammals. A new study shows that the recognition mechanism used for the targeting of switch sequences might be evolutionary conserved.

    • Amy L Kenter
    •  & Palash Bhattacharya
  • News & Views |

    Dendritic cell subsets are thought to become committed to the dendritic cell lineage once they have differentiated from lymphoid or myeloid lineage precursors. However, this tenet has been challenged by data showing plasticity among the different subsets.

    • Anne O'Garra
    •  & Giorgio Trinchieri

Historical Perspective