Volume 5 Issue 10, October 2004

Volume 5 Issue 10

For the proper functioning of the immune system, the innate and adaptive immune responses must contact each other at specific times and locations. This month we focus on Bridging Innate and Adaptive Immunity with a series of specially commissioned articles analyzing how various components of the innate immune response influence adaptive immunity. This content and additional features are free online (nature.com/natureimmunology/focus/bridging_immunity) during October 2004. Cover by Lewis Long.





Research Highlights


News and Views

  • News & Views |

    Lymphocyte adhesion requires rapid responses. Lymphocytes from mice deficient in the Rap effector molecule RAPL lack this property and are therefore deficient in their immune responses.

    • Leo S Price
    •  & Johannes L Bos
  • News & Views |

    The B cell transmembrane glycoprotein modulates immune signaling. Mice containing specific Cd22 mutations show that the extracellular glycan-binding function is regulatory and indicate unexpected complexity in CD22-ligand interactions.

    • Jamey D Marth
  • News & Views |

    The innate inflammatory immune response must be finely tuned to avoid excessive damage to the host. One molecule, A20, is intricately involved in dampening inflammatory signals mediated by both tumor necrosis factor and multiple Toll-like receptors.

    • Neal Silverman
    •  & Katherine Fitzgerald
  • News & Views |

    The physical location of key proteins may turn out to significantly influence the differentiation tack that a cell takes. If clusters of antigen receptors include interferon-γ receptors in their midst, the fate of that T cell may be tipped.

    • Tasha N Sims
    •  & Michael L Dustin



  • Focus |

    Bridging Innate and Adaptive Immunity

    A comprehensive overview, three review articles and a perspective examine how the innate immunity influences the outcome of the adaptive immune response.