Volume 25

  • No. 7 July 2024

    Immune signatures of pain

    Single-cell transcriptomics is used to determine the gene signature of infiltrating immune cells and potential cell–cell interactions between receptors, ligands, ion channels and metabolites expressed on immune cells and sensory neurons in three models of inflammatory pain.

    See Jain et al.

  • No. 6 June 2024

    Bridging the affinity gap in the germinal center

    In this issue, Ray et al. preclinically validate new immunogens to elicit broadly neutralizing antibodies (bnAbs) to the membrane-proximal external region (MPER) epitope on the HIV envelope protein, and demonstrate that germinal center kinetics are driven by affinity gaps between bnAb precursors and competing B cells over time. On the cover, using a retro National Parks postcard style, the affinity gap is portrayed as a canyon, with sturdier or more treacherous bridges for B cells to ‘cross’ via affinity maturation from high-to-high or low-to-high affinity.

    See Ray et al.

  • No. 5 May 2024

    Regulating NK cell effector function

    Li et al. identify the transcription factor MEF2C as essential for human natural killer (NK) cell function and viral immunity in mice and humans. This control is exerted by regulation of lipid metabolism, and deficiency in MEF2C can be overcome by supplementation with oleic acid.

    See Li et al.

  • No. 4 April 2024

    Predicting and evaluating drugs for combination therapy

    Guo and colleagues present a method known as CM-Drug for the identification of combination drugs that can boost the efficacy of immune checkpoint blockade therapy. They validate this method using melanoma and lung cancer models in mice and explore one hit from their screen in further depth, the thyrotropin-releasing hormone (TRH) analogue taltirelin.

    See Guo et al.

  • No. 3 March 2024

    Women in Neuroimmunology

    March is Women’s History Month. This month’s issue celebrates the contributions of female neuroimmunologists.

    For more information, see the Women in Immunology Collection

  • No. 2 February 2024

    Immune dysregulation in long COVID

    Yin et al. use Olink proteomics and single‐cell RNA sequencing (scRNA-seq) analyses to show a dysregulated crosstalk between the cellular and humoral immune responses in individuals with long COVID 8 months after infection with SARS-CoV-2.

    See Kailin Yin et al.

  • No. 1 January 2024

    Second-generation M1-polarized CAR macrophages

    Induced pluripotent stem (iPS) cell-derived macrophages (iMACs) are being used to engineer CAR macrophages for immunotherapy. Zhang and colleagues design second-generation macrophage-specific CARs by integrating CD3ζ and TIR domains, resulting in M1-polarized CAR-iMACs with increased antitumor functions.

    See Zhang et al.