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Volume 24 Issue 2, February 2023

Programmed early-age iNKT cell skin localization

Proper localization and function of immune cells in the skin is crucial for protection and for establishing skin tissue homeostasis. Xiong and colleagues find a developmentally programmed process that directs preferential localization of invariant natural killer T (iNKT) cells into the skin for early local homeostatic regulation.

See Xiong et al.

Image: Yang-ding Lin, University of Texas Health Science Center at San Antonio. Cover design: Amie Fernandez

World View

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Research Highlights

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News & Views

  • TH17 cells combat infection but can also drive pathological inflammation. A TH17 cell NLRP3–caspase-8–caspase-3–GSDME axis is now shown to release the alarmin IL-1α without triggering cell death.

    • Joanna R. Groom
    • James E. Vince
    News & Views
  • In addition to the acute phase of SARS-CoV-2 infection, a significant percentage of patients experience a prolonged illness with varying symptomatology. Longitudinal SARS-CoV-2 patient-centric immunologic, inflammatory and metabolic data collection has allowed the generation of a composite signature to predict recovery.

    • Randy Q. Cron
    News & Views
  • Human resident memory T (TRM) cells clonally segregate in distinct tissues, with gene expression signatures tailored to those sites. Hence, beyond a shared language of residency, TRM cells may acquire local dialects to provide site-specific immunity.

    • Nicholas J. Maurice
    • Stephen C. Jameson
    News & Views
  • A specialized subset of iNKT cells populates the skin in early life, where their supply of transferrin regulates iron metabolism to promote hair follicle development.

    • Hui-Fern Koay
    • Laura K. Mackay
    News & Views
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Meeting Reports

  • Starting on 19 September 2022, the very first ImmunOctoberfest conference took place in Raitenhaslach, Germany, bringing together scientists from all over the world to discuss ‘bridging innovation and translation in T cell immunotherapy’.

    • Anna M. Schulz
    • Caitlin C. Zebley
    • Dietmar Zehn
    Meeting Report
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Research Briefings

  • Sterol regulatory element-binding protein (SREBP) signaling regulates cellular lipid homeostasis. We discovered that SREBP signaling in B cells is crucial for antibody responses and the generation of germinal centers and B cell memory compartments in response to vaccination. These results provide mechanistic insights that couple sterol metabolism to the quality and longevity of humoral immunity.

    Research Briefing
  • Exhausted effector T cells accumulate in tumors and are the intended targets of cancer immunotherapy. New data suggest that upon infiltration and subsequent exhaustion in the tumor microenvironment, these T cells can take on an immunosuppressive function — and work against the immune response to cancer.

    Research Briefing
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  • Ruffieux, Hess and colleagues analyze longitudinal phenotyping of patients with coronavirus disease 2019 to show that covariation of innate immune cell numbers, kynurenine metabolites and lipid metabolites influence the restoration of homeostasis, the risk of death and that of long COVID.

    • Hélène Ruffieux
    • Aimee L. Hanson
    • Christoph Hess
    Resource Open Access
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Amendments & Corrections

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