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Volume 22 Issue 11, November 2021

Circadian clocks control DC migration

Scheiermann and colleagues show that circadian clocks control the infiltration of dendritic cells into skin lymphatics in mice and humans, with a peak migration to the lymph nodes during the rest phase.

See Holtkamp et al.

Image Credit: Lauren Heslop. Cover art: Stephan Holtkamp

Volume 22 Issue 11


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  • If new treatments for immune-mediated inflammatory diseases (IMIDs) are to emerge, then a radical new approach that moves the field from one that is based on clinical signs and symptoms to one that is based on immunological and molecular mechanisms is urgently needed. This requires a new way of thinking: that IMIDs should be approached as having shared common pathogenic cells and pathways, and that therapies should be targeted at these cells and processes rather than clinical features.

    • Christopher D. Buckley
    • Lorna Chernajovsky
    • Paul P. Tak
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Research Highlights

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News & Views

  • During acute COVID-19, there is little correlation between the nose and blood in terms of antibodies or cytokines; instead, these factors are associated with nasal microbiota.

    • Simon P. Jochems
    • Daniela M. Ferreira
    • Hermelijn H. Smits
    News & Views
  • Thrombosis complicates SARS-CoV-2 infection and vaccination. Recent data are being used to identify the autoimmune antibody repertoires responsible for the excessive activation of coagulation and platelets.

    • Zaverio M. Ruggeri
    • Wolfram Ruf
    News & Views
  • The retention of erythroid mitochondria, a feature associated with impairments in the ubiquitin–proteasome system, is detected in a subset of pediatric patients with lupus and is associated with the type I interferon pathway.

    • Mariana J. Kaplan
    News & Views
  • Infections are known to induce epigenetic rewiring in myeloid cells, a phenomenon known as trained immunity, which protects against re-infection. New data show that, in mice, trained immunity can be inherited, possibly by gametic DNA methylation and chromatin remodeling linked to immune traits.

    • Paola de Candia
    • Giuseppe Matarese
    News & Views
  • Conjugation of the ubiquitin-like protein ISG15 to targets (ISGylation) benefits antiviral defense. However, SARS-CoV-2 induces human macrophages to preferentially secrete ISG15 via its papain-like protease, and extracellular non-conjugated ISG15 acts as a cytokine to exacerbate SARS-CoV-2-triggered inflammation.

    • Xuetao Cao
    News & Views
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Meeting Reports

  • On 27 ̶ 29 July 2021, the National Institute of Allergy and Infectious Diseases (NIAID) hosted a virtual workshop on the topic of secondary vaccine effects to discuss existing evidence, potential immunological mechanisms and associated public health implications.

    • Aaron M. Joffe
    • Eun-Chung Park
    • Kimberly M. Thompson
    Meeting Report
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  • ILC2 metabolism has been largely unexplored. Di Santo and colleagues examine metabolic profiles from naive and cytokine-activated ILC2s and find that IL-33-triggered ILC2s rely on distinct metabolic pathways to sustain proliferation and function.

    • Laura Surace
    • Jean-Marc Doisne
    • James P. Di Santo
    Letter Open Access
  • Scheiermann and colleagues show that circadian clocks control the infiltration of dendritic cells into skin lymphatics in mice and humans, with a peak migration to the lymph nodes during the rest phase.

    • Stephan J. Holtkamp
    • Louise M. Ince
    • Christoph Scheiermann
    Letter Open Access
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  • Pediatric COVID-19 can be associated with subsequent multisystem inflammatory syndrome in children (MIS-C), but how these pathologies are related or differ is unclear. Here the authors compare and contrast pediatric COVID-19 and MIS-C immunophenotypes using SARS-CoV-2 antibody fingerprinting proteomics.

    • Supriya Ravichandran
    • Juanjie Tang
    • Surender Khurana
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Amendments & Corrections

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