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Volume 21 Issue 4, April 2020

Volume 21 Issue 4

MAIT cell antigen recognition

Mucosa-associated invariant T (MAIT) cells recognize vitamin B metabolites presented by the molecule MR1. Rossjohn and colleagues generate multiple altered metabolite ligands and determine their structures in the context of MR1 and the TCR to develop a generalized framework for MAIT cell antigen recognition.

See Awad et al.

Image: Erica Tandori. Cover Design: Erin Dewalt.


Research Highlights

News & Views

  • News & Views |

    Comprehensive analysis of CD8+ T cell populations specific to cytomegalovirus reveals that the evolution of the T cell antigen receptor repertoire during chronic infections is characterized by the expansion of low-affinity clones.

    • Anke Redeker
    • Ramon Arens
  • News & Views |

    The ubiquitin-editing enzyme A20 has a pivotal role in restricting autoimmune and inflammatory responses. New studies suggest that A20 prevents inflammatory diseases using a non-catalytic mechanism involving ubiquitin binding.

    • Shao-Cong Sun
  • News & Views |

    γδ T cells are critical contributors to tissue homeostasis. Recent research identifies an unexpected role for γδ T cell–derived IL-17F in promoting sympathetic innervation and tissue thermogenesis through the induction of the cytokine TGF-β in adipose cells.

    • Maria Ciofani

Review Articles




Amendments & Corrections


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