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Volume 20 Issue 3, March 2019

Volume 20 Issue 3

Fetal intestinal memory CD4 +T cells

Koning and colleagues used mass cytometry, single-cell RNA-seq and high-throughput TCR sequencing to characterize the CD4+ T cell compartment in the human fetal intestine.

See Koning et al.

IMAGE: Na Li COVER DESIGN: Erin Dewalt

Research Highlights

News & Views

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    A multivalent vaccine that presents diverse influenza virus subtype H1 hemagglutinins on its surface induces broadly neutralizing antibodies in an animal model by displaying conserved epitopes at higher density than strain-specific epitopes.

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    The zinc transporter ZIP7 positively regulates signaling via the BCR during early B cell development in mice and humans. Impairment of ZIP7 function results in a novel primary immunodeficiency.

    • Toshiyuki Fukada
    • Shintaro Hojyo
    • Teruhisa Takagishi
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    Combined immunotherapy using checkpoint blockade (anti-CTLA4 and anti-PD-1) and the DPP4 inhibitor sitagliptin reveals the existence of a T cell– and eosinophil-targeted immunotherapy approach for solid tumors.

    • Ariel Munitz
    • Simon Patrick Hogan
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    In patients with rheumatoid arthritis, decreased abundance of the N-myristoyltransferase NMT1 in CD4+ T cells prevents N-myristoylation of the AMP-activated protein kinase AMPK and its localization to the lysosomal membrane, which leads to increased activation of the metabolic checkpoint kinase complex mTORC1 and proinflammatory T cell phenotypes.

    • David K. Finlay
  • News & Views |

    The transition of the fetus from the womb to the external world represents an extraordinary challenge. The generation of memory T cells before birth may serve an important role in preparation for this fundamental transition.

    • Ai Ing Lim
    • Oliver J. Harrison
    • Yasmine Belkaid

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