Volume 20 Issue 11, November 2019

Volume 20 Issue 11

Sensory neurons and skin allergy

Gaudenzio and colleagues show that house dust mite extracts directly activate TRPV1+ sensory neurons, which drive the development of allergic skin inflammation by inducing the degranulation of mast cells through release of the neuropeptide substance P.

See Serhan et al.

Image: Nicolas Gaudenzio. Cover Design: Erin Dewalt

Editorial

  • Editorial |

    Good practices and new initiatives increase the efficiency of the review process and the accessibility of peer-reviewed research.

Comment

  • Comment |

    Therapeutic innovations of potentially great clinical impact should embrace the overarching values of research accountability, data transparency and validation through the scientific peer-review process.

    • Dimitrios C. Mastellos
    • , Anna M. Blom
    • , E. Sander Connolly
    • , Mohamed R. Daha
    • , Brian V. Geisbrecht
    • , Berhane Ghebrehiwet
    • , Piet Gros
    • , George Hajishengallis
    • , V. Michael Holers
    • , Markus Huber-Lang
    • , Taroh Kinoshita
    • , Tom E. Mollnes
    • , Robert A. Montgomery
    • , B. Paul Morgan
    • , Bo Nilsson
    • , Ruben Pio
    • , Daniel Ricklin
    • , Antonio M. Risitano
    • , Ronald P. Taylor
    • , Alberto Mantovani
    • , John P. A. Ioannidis
    •  & John D. Lambris

Research Highlights

News & Views

  • News & Views |

    Quantitative mass spectrometry applied to T cell activation reveals key insights into signal-transduction pathways. These data identify selective alterations in the concentration of proteins in activated T cells and detail previously undescribed protein–protein interactions.

    • James M. Conley
    •  & Leslie J. Berg
  • News & Views |

    Chronic exposure to fungal antigen drives the development of two subsets of CD4+ TRM cells, distinguished by high or low expression of the integrin CD103, with opposing roles in inflammation-induced lung fibrosis.

    • Maximilien Evrard
    •  & Laura K. Mackay
  • News & Views |

    Cyclic dinucleotides (CDNs) are potent activators of the innate immune sensor STING. The identification of a CDN importer sheds new light on the regulation of extracellular CDNs.

    • Baptiste Guey
    •  & Andrea Ablasser
  • News & Views |

    A report sheds new light on the molecular mechanisms responsible for the discrimination of self versus non-self TCR ligands and reveals the crucial role of the kinetics of LAT tyrosine phosphorylation in this.

    • Enrique Aguado
    •  & Mikel M. Arbulo-Echevarria
  • News & Views |

    The mechano-sensitive membrane channel PIEZO1 coordinates immune defense in the lungs.

    • Pavel Tolar
    •  & Andreas Wack

Review Articles

Articles

  • Article |

    Gaudenzio and colleagues show that house dust mite extracts directly activate TRPV1+ sensory neurons, which promote allergic skin inflammation by inducing the degranulation of mast cells through the release of the neuropeptide substance P and activation of MRGPRB2.

    • Nadine Serhan
    • , Lilian Basso
    • , Riccardo Sibilano
    • , Camille Petitfils
    • , James Meixiong
    • , Chrystelle Bonnart
    • , Laurent L. Reber
    • , Thomas Marichal
    • , Philipp Starkl
    • , Nicolas Cenac
    • , Xinzhong Dong
    • , Mindy Tsai
    • , Stephen J. Galli
    •  & Nicolas Gaudenzio
  • Article |

    Marichal and colleagues show that lung neutrophils in mice exposed to three distinct pro-allergic conditions release neutrophil extracellular traps that potentiate allergen uptake by dendritic cells and type 2 allergic inflammation.

    • Coraline Radermecker
    • , Catherine Sabatel
    • , Céline Vanwinge
    • , Cecilia Ruscitti
    • , Pauline Maréchal
    • , Fabienne Perin
    • , Joey Schyns
    • , Natacha Rocks
    • , Marie Toussaint
    • , Didier Cataldo
    • , Sebastian L Johnston
    • , Fabrice Bureau
    •  & Thomas Marichal
  • Article |

    Tissue-resident memory T cells (TRM cells) are important for the localized protection of specific body compartments. Nakayama and colleagues identify heterogeneity in lung TRM cells, with one subset driving fibrosis and inflammation and another reining in pathology in response to fungal challenge.

    • Tomomi Ichikawa
    • , Kiyoshi Hirahara
    • , Kota Kokubo
    • , Masahiro Kiuchi
    • , Ami Aoki
    • , Yuki Morimoto
    • , Jin Kumagai
    • , Atsushi Onodera
    • , Naoko Mato
    • , Damon J. Tumes
    • , Yoshiyuki Goto
    • , Koichi Hagiwara
    • , Yutaka Inagaki
    • , Tim Sparwasser
    • , Kazuyuki Tobe
    •  & Toshinori Nakayama
  • Article |

    TCR ligation activates the tyrosine kinase ZAP-70 to phosphorylate the adapter LAT, which then coordinates TCR proximal signaling cascades. Weiss and colleagues show LAT-Y132 is critical to TCR ligand discrimination, as its phosphorylation represents a rate-limiting step in T cell activation due to a conserved glycine residue at position 131.

    • Wan-Lin Lo
    • , Neel H. Shah
    • , Sara A. Rubin
    • , Weiguo Zhang
    • , Veronika Horkova
    • , Ian R. Fallahee
    • , Ondrej Stepanek
    • , Leonard I. Zon
    • , John Kuriyan
    •  & Arthur Weiss
  • Article |

    CRISPR activation (CRISPRa) can target select genes and, rather than being used to delete them, can be used to activate their expression. Chen and colleagues use a CRISPRa-based approach to drive the expression of multiple endogenous genes in tumors and presentation of the antigens encoded, thus enhancing antitumor immune responses.

    • Guangchuan Wang
    • , Ryan D. Chow
    • , Zhigang Bai
    • , Lvyun Zhu
    • , Youssef Errami
    • , Xiaoyun Dai
    • , Matthew B. Dong
    • , Lupeng Ye
    • , Xiaoya Zhang
    • , Paul A. Renauer
    • , Jonathan J. Park
    • , Li Shen
    • , Hanghui Ye
    • , Charles S. Fuchs
    •  & Sidi Chen

    Collection:

  • Article |

    Peyer’s patches (PPs) are sites of antibody production in the gut mucosa. Carroll and colleagues show the mechanosensory channel protein Piezo1 is required for the homeostatic maintenance of PPs. Specific loss of Piezo1 in FRCs disrupt PP structure and function, resulting in reduction of fecal IgA production and gut immunity.

    • Jonathan E. Chang
    • , Matthew B. Buechler
    • , Elise Gressier
    • , Shannon J. Turley
    •  & Michael C. Carroll
  • Article |

    Immature B cells expressing self-reactive BCRs induce anergy programs to promote tolerance. Busslinger and colleagues show that the transcription factor Ikaros enforces anergy by inducing transcription of negative-feedback regulators of the BCR and TLR–MyD88 pathways.

    • Tanja A. Schwickert
    • , Hiromi Tagoh
    • , Karina Schindler
    • , Maria Fischer
    • , Markus Jaritz
    •  & Meinrad Busslinger

Resources

  • Resource |

    Malissen and colleagues provide a quantitative systems-level analysis of 15 distinct signalosomes that form within minutes of TCR stimulation of primary CD4+ T cells.

    • Guillaume Voisinne
    • , Kristof Kersse
    • , Karima Chaoui
    • , Liaoxun Lu
    • , Julie Chaix
    • , Lichen Zhang
    • , Marisa Goncalves Menoita
    • , Laura Girard
    • , Youcef Ounoughene
    • , Hui Wang
    • , Odile Burlet-Schiltz
    • , Hervé Luche
    • , Frédéric Fiore
    • , Marie Malissen
    • , Anne Gonzalez de Peredo
    • , Yinming Liang
    • , Romain Roncagalli
    •  & Bernard Malissen
  • Resource |

    Cantrell and colleagues perform a comparative quantitative mass spectrometric analysis of the proteomes of naïve and activated CD4+ and CD8+ T cells. Proteomes are dynamically regulated and mTORC1 inhibition leads to differential consequences depending on cell state.

    • Andrew J. M. Howden
    • , Jens L. Hukelmann
    • , Alejandro Brenes
    • , Laura Spinelli
    • , Linda V. Sinclair
    • , Angus I. Lamond
    •  & Doreen A. Cantrell

Amendments & Corrections

  • Author Correction |

    • Smita Kulkarni
    • , Alexandra Lied
    • , Viraj Kulkarni
    • , Marijana Rucevic
    • , Maureen P. Martin
    • , Victoria Walker-Sperling
    • , Stephen K. Anderson
    • , Rodger Ewy
    • , Sukhvinder Singh
    • , Hoang Nguyen
    • , Paul J. McLaren
    • , Mathias Viard
    • , Vivek Naranbhai
    • , Chengcheng Zou
    • , Zhansong Lin
    • , Hiroyuki Gatanaga
    • , Shinichi Oka
    • , Masafumi Takiguchi
    • , Chloe L. Thio
    • , Joseph Margolick
    • , Gregory D. Kirk
    • , James J. Goedert
    • , W. Keith Hoots
    • , Steven G. Deeks
    • , David W. Haas
    • , Nelson Michael
    • , Bruce Walker
    • , Sylvie Le Gall
    • , Fatema Z. Chowdhury
    • , Xu G. Yu
    •  & Mary Carrington
  • Author Correction |

    • Vivek Verma
    • , Rajeev K Shrimali
    • , Shamim Ahmad
    • , Winjie Dai
    • , Hua Wang
    • , Sumin Lu
    • , Rahul Nandre
    • , Pankaj Gaur
    • , Jose Lopez
    • , Moshe Sade-Feldman
    • , Keren Yizhak
    • , Stacey L. Bjorgaard
    • , Keith T. Flaherty
    • , Jennifer A. Wargo
    • , Genevieve M. Boland
    • , Ryan J. Sullivan
    • , Gad Getz
    • , Scott A. Hammond
    • , Ming Tan
    • , Jingjing Qi
    • , Phillip Wong
    • , Taha Merghoub
    • , Jedd Wolchok
    • , Nir Hacohen
    • , John E. Janik
    • , Mikayel Mkrtichyan
    • , Seema Gupta
    •  & Samir N. Khleif
  • Author Correction |

    • Brian C. Miller
    • , Debattama R. Sen
    • , Rose Al Abosy
    • , Kevin Bi
    • , Yamini V. Virkud
    • , Martin W. LaFleur
    • , Kathleen B. Yates
    • , Ana Lako
    • , Kristen Felt
    • , Girish S. Naik
    • , Michael Manos
    • , Evisa Gjini
    • , Juhi R. Kuchroo
    • , Jeffrey J. Ishizuka
    • , Jenna L. Collier
    • , Gabriel K. Griffin
    • , Seth Maleri
    • , Dawn E. Comstock
    • , Sarah A. Weiss
    • , Flavian D. Brown
    • , Arpit Panda
    • , Margaret D. Zimmer
    • , Robert T. Manguso
    • , F. Stephen Hodi
    • , Scott J. Rodig
    • , Arlene H. Sharpe
    •  & W. Nicholas Haining
  • Author Correction |

    • Evan Der
    • , Hemant Suryawanshi
    • , Pavel Morozov
    • , Manjunath Kustagi
    • , Beatrice Goilav
    • , Saritha Ranabothu
    • , Peter Izmirly
    • , Robert Clancy
    • , H. Michael Belmont
    • , Mordecai Koenigsberg
    • , Michele Mokrzycki
    • , Helen Rominieki
    • , Jay A. Graham
    • , Juan P. Rocca
    • , Nicole Bornkamp
    • , Nicole Jordan
    • , Emma Schulte
    • , Ming Wu
    • , James Pullman
    • , Kamil Slowikowski
    • , Soumya Raychaudhuri
    • , Joel Guthridge
    • , Judith James
    • , Jill Buyon
    • , Thomas Tuschl
    • , Chaim Putterman
    • , Jennifer Anolik
    • , William Apruzzese
    • , Arnon Arazi
    • , Celine Berthier
    • , Michael Brenner
    • , Jill Buyon
    • , Robert Clancy
    • , Sean Connery
    • , Melissa Cunningham
    • , Maria Dall’Era
    • , Anne Davidson
    • , Evan Der
    • , Andrea Fava
    • , Chamith Fonseka
    • , Richard Furie
    • , Dan Goldman
    • , Rohit Gupta
    • , Joel Guthridge
    • , Nir Hacohen
    • , David Hildeman
    • , Paul Hoover
    • , Raymond Hsu
    • , Judith James
    • , Ruba Kado
    • , Kenneth Kalunian
    • , Diane Kamen
    • , Mattias Kretzler
    • , Holden Maecker
    • , Elena Massarotti
    • , William McCune
    • , Maureen McMahon
    • , Meyeon Park
    • , Fernanda Payan-Schober
    • , William Pendergraft
    • , Michelle Petri
    • , Mina Pichavant
    • , Chaim Putterman
    • , Deepak Rao
    • , Soumya Raychaudhuri
    • , Kamil Slowikowski
    • , Hemant Suryawanshi
    • , Thomas Tuschl
    • , Paul Utz
    • , Dia Waguespack
    • , David Wofsy
    •  & Fan Zhang
  • Author Correction |

    • Dimitrios C. Mastellos
    • , Anna M. Blom
    • , E. Sander Connolly
    • , Mohamed R. Daha
    • , Brian V. Geisbrecht
    • , Berhane Ghebrehiwet
    • , Piet Gros
    • , George Hajishengallis
    • , V. Michael Holers
    • , Markus Huber-Lang
    • , Taroh Kinoshita
    • , Tom E. Mollnes
    • , Robert A. Montgomery
    • , B. Paul Morgan
    • , Bo Nilsson
    • , Ruben Pio
    • , Daniel Ricklin
    • , Antonio M. Risitano
    • , Ronald P. Taylor
    • , Alberto Mantovani
    • , John P. A. Ioannidis
    •  & John D. Lambris