Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 20 Issue 11, November 2019

Volume 20 Issue 11

Sensory neurons and skin allergy

Gaudenzio and colleagues show that house dust mite extracts directly activate TRPV1+ sensory neurons, which drive the development of allergic skin inflammation by inducing the degranulation of mast cells through release of the neuropeptide substance P.

See Serhan et al.

Image: Nicolas Gaudenzio. Cover Design: Erin Dewalt


  • Editorial |

    Good practices and new initiatives increase the efficiency of the review process and the accessibility of peer-reviewed research.


Research Highlights

News & Views

  • News & Views |

    Quantitative mass spectrometry applied to T cell activation reveals key insights into signal-transduction pathways. These data identify selective alterations in the concentration of proteins in activated T cells and detail previously undescribed protein–protein interactions.

    • James M. Conley
    •  & Leslie J. Berg
  • News & Views |

    Chronic exposure to fungal antigen drives the development of two subsets of CD4+ TRM cells, distinguished by high or low expression of the integrin CD103, with opposing roles in inflammation-induced lung fibrosis.

    • Maximilien Evrard
    •  & Laura K. Mackay
  • News & Views |

    Cyclic dinucleotides (CDNs) are potent activators of the innate immune sensor STING. The identification of a CDN importer sheds new light on the regulation of extracellular CDNs.

    • Baptiste Guey
    •  & Andrea Ablasser
  • News & Views |

    A report sheds new light on the molecular mechanisms responsible for the discrimination of self versus non-self TCR ligands and reveals the crucial role of the kinetics of LAT tyrosine phosphorylation in this.

    • Enrique Aguado
    •  & Mikel M. Arbulo-Echevarria
  • News & Views |

    The mechano-sensitive membrane channel PIEZO1 coordinates immune defense in the lungs.

    • Pavel Tolar
    •  & Andreas Wack

Review Articles



Amendments & Corrections


Quick links