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horror autotoxicusmastzellenet alpage 216page 193Background: photomicrograph (magnification x300) is extensive vascular congestion in liver after challenge with same peptide.
Notch is heavily involved in T cell lineage commitment . . . or is it? New data indicates that neither CD4 nor CD8 cell maturation is Notch1-dependent, whereas Notch1 is critical for earlier steps in T cell development.
Proteins are digested into peptides for presentation by MHC to T cells. A recent paper in Science reports that some lipids also undergo processing in order to be presented by the unconventional class I protein CD1.
What determines whether immune responses against a self-peptide can evoke an anaphylactic response? New evidence describes anaphylaxis that appears to be governed by thymic expression of the self-antigen.
New data shows that NADPH oxidase activation by Rac2 involves an insert-dependent interaction between Rac2 and cyt b. This unique activation mechanism has far-reaching implications for the regulation of related signaling systems.
A minimal half-life of the TCR-pMHC interaction is required for complete T cell signaling (the kinetic proof reading model). In an extension to this model it is clear that the dwell time or half-life of TCR-pMHC interaction is also critical for T cell activation
In addition to the TCR and classical MHC class I, MHC class 1–like molecules can interact with a variety of receptors that play a role in T cell activation. Engagement of NKG2D on CMV-specific αβ CD8+ cells by MIC was found to provide them with a costimulatory signal and augment their cytotoxic response.
