Volume 19 Issue 3, March 2018

Volume 19 Issue 3

The presentation of antigen by germinal center B cells to follicular T cells engenders the process of antibody affinity maturation and humoral memory. Pierce and colleagues show TLR9 signaling in B cells antagonizes B cell–mediated antigen presentation, which leads to enhanced generation of short-lived plasma cells and production of lower-affinity antibodies.

Image credit: Munir Akkaya, David W. Dorward Cover Design: Erin Dewalt

Correspondence

  • Correspondence |

    • Ana Mafalda Santos
    • , Aleks Ponjavic
    • , Marco Fritzsche
    • , Ricardo A. Fernandes
    • , Jorge Bernardino de la Serna
    • , Martin J. Wilcock
    • , Falk Schneider
    • , Iztok Urbančič
    • , James McColl
    • , Consuelo Anzilotti
    • , Kristina A. Ganzinger
    • , Meike Aßmann
    • , David Depoil
    • , Richard J. Cornall
    • , Michael L. Dustin
    • , David Klenerman
    • , Simon J. Davis
    • , Christian Eggeling
    •  & Steven F. Lee

Research Highlights

News & Views

  • News & Views |

    Large-scale genetic and immunological profiling reveals key environmental and genetic drivers of immunological diversity within the healthy human population.

    • Adrian Liston
    •  & An Goris
  • News & Views |

    Tumor cells downregulate type I interferon responses through their delivery of immunomodulatory exosomes, which has implications for antiviral suppression in people with cancer.

    • Akinori Takaoka
  • News & Views |

    The transcription factor Hoxb5 is expressed specifically in hematopoietic stem cells, yet its ectopic expression in mouse B cell progenitors induces their conversion into functional T cells in vivo.

    • Gregoire Stik
    •  & Thomas Graf

Review Articles

  • Review Article |

    Primary liver cancer, of which hepatocellular carcinoma is the most common form, is the second leading cause of cancer-related death. Heikenwalder and colleagues review the important inflammatory component underlying hepatocellular carcinoma and consider potential directions for therapy.

    • Marc Ringelhan
    • , Dominik Pfister
    • , Tracy O’Connor
    • , Eli Pikarsky
    •  & Mathias Heikenwalder

Articles

  • Article |

    Cancer can be associated with alterations in innate immunity. Gao et al. demonstrate that these alterations arise from immunomodulatory exosomes released by tumors, which then dampen the production of type I interferons by macrophages.

    • Liang Gao
    • , Lin Wang
    • , Tong Dai
    • , Ke Jin
    • , Zhengkui Zhang
    • , Shuai Wang
    • , Feng Xie
    • , Pengfei Fang
    • , Bing Yang
    • , Huizhe Huang
    • , Hans van Dam
    • , Fangfang Zhou
    •  & Long Zhang
  • Article |

    Polymorphisms in the autophagy protein Atg16l are associated with human inflammatory bowel disease. Murthy and colleagues demonstrate that atg16l is crucial to autophagocytic degradation of the innate adapter TRIF and thereby restrains pathological over-production of type I interferons.

    • Mohammad Samie
    • , Junghyun Lim
    • , Erik Verschueren
    • , Joshua M. Baughman
    • , Ivan Peng
    • , Aaron Wong
    • , Youngsu Kwon
    • , Yasin Senbabaoglu
    • , Jason A. Hackney
    • , Mary Keir
    • , Brent Mckenzie
    • , Donald S. Kirkpatrick
    • , Menno van Lookeren Campagne
    •  & Aditya Murthy
  • Article |

    The presentation of antigen by germinal-center B cells to follicular T cells engenders the process of antibody affinity maturation and humoral memory. Pierce and colleagues show that TLR9 signaling in B cells antagonizes B cell–mediated antigen presentation, which leads to the enhanced generation of short-lived plasma cells and the production of lower-affinity antibodies.

    • Munir Akkaya
    • , Billur Akkaya
    • , Ann S. Kim
    • , Pietro Miozzo
    • , Haewon Sohn
    • , Mirna Pena
    • , Alexander S. Roesler
    • , Brandon P. Theall
    • , Travis Henke
    • , Juraj Kabat
    • , Jinghua Lu
    • , David W. Dorward
    • , Eric Dahlstrom
    • , Jeff Skinner
    • , Louis H. Miller
    •  & Susan K. Pierce
  • Article |

    Affinity maturation and positive selection occur in germinal centers. Turner and colleagues demonstrate that the RNA-binding protein PTBP1 serves an essential B cell–intrinsic role by regulating the abundance and alternate splicing of transcripts in germinal center B cells.

    • Elisa Monzón-Casanova
    • , Michael Screen
    • , Manuel D. Díaz-Muñoz
    • , Richard M. R. Coulson
    • , Sarah E. Bell
    • , Greta Lamers
    • , Michele Solimena
    • , Christopher W. J. Smith
    •  & Martin Turner
  • Article |

    Wang and colleagues show that the transcription factor Hoxb5, which is expressed in uncommitted hematopoietic progenitor cells but is absent from committed B cells and T cells, can reprogram pro-pre-B cells into functional early T cell lineage progenitors.

    • Mengyun Zhang
    • , Yong Dong
    • , Fangxiao Hu
    • , Dan Yang
    • , Qianhao Zhao
    • , Cui Lv
    • , Ying Wang
    • , Chengxiang Xia
    • , Qitong Weng
    • , Xiaofei Liu
    • , Chen Li
    • , Peiqing Zhou
    • , Tongjie Wang
    • , Yuxian Guan
    • , Rongqun Guo
    • , Lijuan Liu
    • , Yang Geng
    • , Hongling Wu
    • , Juan Du
    • , Zheng Hu
    • , Sheng Xu
    • , Jiekai Chen
    • , Aibin He
    • , Bing Liu
    • , Demin Wang
    • , Yong-Guang Yang
    •  & Jinyong Wang

Resources

  • Resource |

    Both environmental factors and genetic factors influence human immunity. Albert and colleagues leverage data from the Milieu Intérieur Consortium to comprehensively describe the effects of lifestyle, environment and genetics on human innate and adaptive immunity.

    • Etienne Patin
    • , Milena Hasan
    • , Jacob Bergstedt
    • , Vincent Rouilly
    • , Valentina Libri
    • , Alejandra Urrutia
    • , Cécile Alanio
    • , Petar Scepanovic
    • , Christian Hammer
    • , Friederike Jönsson
    • , Benoît Beitz
    • , Hélène Quach
    • , Yoong Wearn Lim
    • , Julie Hunkapiller
    • , Magge Zepeda
    • , Cherie Green
    • , Barbara Piasecka
    • , Claire Leloup
    • , Lars Rogge
    • , François Huetz
    • , Isabelle Peguillet
    • , Olivier Lantz
    • , Magnus Fontes
    • , James P. Di Santo
    • , Stéphanie Thomas
    • , Jacques Fellay
    • , Darragh Duffy
    • , Lluís Quintana-Murci
    • , Matthew L. Albert
    • , Laurent Abel
    • , Andres Alcover
    • , Kalle Astrom
    • , Philippe Bousso
    • , Pierre Bruhns
    • , Ana Cumano
    • , Caroline Demangel
    • , Ludovic Deriano
    • , James P. Di Santo
    • , Françoise Dromer
    • , Darragh Duffy
    • , Gérard Eberl
    • , Jost Enninga
    • , Jacques Fellay
    • , Antonio Freitas
    • , Odile Gelpi
    • , Ivo Gomperts Boneca
    • , Serge Hercberg
    • , Olivier Lantz
    • , Claude Leclerc
    • , Hugo Mouquet
    • , Etienne Patin
    • , Sandra Pellegrini
    • , Stanislas Pol
    • , Lars Rogge
    • , Anavaj Sakuntabhai
    • , Olivier Schwartz
    • , Benno Schwikowski
    • , Spencer Shorte
    • , Vassili Soumelis
    • , Frédéric Tangy
    • , Eric Tartour
    • , Antoine Toubert
    • , Marie-Noëlle Ungeheuer
    • , Lluís Quintana-Murci
    •  & Matthew L. Albert