Volume 19 Issue 2, February 2018

Volume 19 Issue 2

CD8+ T cell immunosurveillance dynamics influence the outcome of intracellular infections and cancer. Masopust and colleagues show that mucosal tissue–resident memory CD8+ T cells proliferate in situ in response to local antigen and dominate the local recall response.

Image credit: Kevin Osum and Lalit Beura Cover Design: Erin Dewalt

Research Highlights

News & Views

  • News & Views |

    The transcription factor Aire restrains the transcriptional duration and amplitude of tissue-specific self-antigens by opposing the activity of the chromatin remodeler Brg1—a process required for immune tolerance.

    • Alexandra Bortnick
    •  & Cornelis Murre
  • News & Views |

    CD8+ tissue-resident memory T cells (TRM cells) in two mucosal tissues, the skin and the female reproductive tract, proliferate in situ to generate a secondary pool of TRM cells that does not exit into the circulation.

    • Jun Siong Low
    •  & Susan M. Kaech
  • News & Views |

    Detrimental levels of intracellular reactive oxygen species engage a caspase-independent and non-inflammatory cell death called ‘oxeiptosis’ that serves as an important mechanism in diminishing inflammation.

    • Sannula Kesavardhana
    •  & Thirumala-Devi Kanneganti
  • News & Views |

    ERAdP, an endoplasmic reticulum (ER)-resident protein with similar mechanistic features as the innate immune adaptor STING, controls inflammatory cytokine release, but not that of type I interferon, in response to bacterial cyclic di-AMP.

    • Martin Roelsgaard Jakobsen

Review Articles

  • Review Article |

    Gabrilovich and colleagues review the origin and nature of myeloid-derived suppressor cells, as well as their distinctive features and biological roles in cancer, infectious diseases, autoimmunity, obesity and pregnancy.

    • Filippo Veglia
    • , Michela Perego
    •  & Dmitry Gabrilovich