Volume 19 Issue 1, January 2018

Volume 19 Issue 1

Plasmacytoid dendritic cells (pDCs) are known for their copious production of type I interferons. Soumelis and colleagues show that functionally and transcriptomically distinct human pDC populations can be generated from a single microbial or cytokine stimulus. Article

Image: Solana Alculumbre Cover design: Erin Dewalt

Research Highlights

News & Views

  • News & Views |

    Damaged mitochondria are targeted for mitophagy by the Pink–Parkin ubiquitin pathway. The mitochondrial ATPase Atad3a prevents aberrant activation of Pink and protects hematopoietic stem cells.

    • Chong Yang
    •  & Toshio Suda
  • News & Views |

    A new ‘alarm mechanism’ of the innate immune system that signals the presence of nuclear viruses involves the sensing of host 5S rRNA by RIG-I.

    • Andrew G. Bowie
  • News & Views |

    A previously unknown role is identified for a pathway that involves major histocompatibility complex class I and an inhibitory receptor, LILRB1, that regulates the phagocytosis of cancer cells by macrophages and contributes to resistance directed against the signal-regulatory protein CD47.

    • Cheng Cheng Zhang
    •  & Yang-Xin Fu
  • News & Views |

    Single-cell sequencing identifies novel subtypes of intestinal epithelial cells and their molecular signatures, which reveals new principles for gut homeostasis and the response to infection.

    • Yujung Michelle Lee
    •  & Janelle S. Ayres

Review Articles

Articles

  • Article |

    The survival of hematopoietic stem cells requires tight regulation of mitophagy. Lin and colleagues show that Atad3a regulates mitophagy in these cells by sequestering the mitophagy initiator Pink1 and directing its import via the mitochondrial Tom40–Tim23 complex.

    • Guoxiang Jin
    • , Chuan Xu
    • , Xian Zhang
    • , Jie Long
    • , Abdol Hossein Rezaeian
    • , Chunfang Liu
    • , Mark E. Furth
    • , Steven Kridel
    • , Boris Pasche
    • , Xiu-Wu Bian
    •  & Hui-Kuan Lin
  • Article |

    RIG-I is a cytosolic RNA sensor. Gack and colleagues show that herpesviruses, duplex DNA viruses, also activate RIG-I by inducing cytoplasmic translocation and unmasking of an endogenous host 5S ribosomal pseudogene RNA, RNA5SP141.

    • Jessica J. Chiang
    • , Konstantin M. J. Sparrer
    • , Michiel van Gent
    • , Charlotte Lässig
    • , Teng Huang
    • , Nikolaus Osterrieder
    • , Karl-Peter Hopfner
    •  & Michaela U. Gack
  • Article |

    Plasmacytoid dendritic cells (pDCs) are known for their copious IFN-I production. Soumelis and colleagues show that functionally and transcriptomically distinct human pDC populations can be generated from a single microbial or cytokine stimulus.

    • Solana G. Alculumbre
    • , Violaine Saint-André
    • , Jeremy Di Domizio
    • , Pablo Vargas
    • , Philemon Sirven
    • , Pierre Bost
    • , Mathieu Maurin
    • , Paolo Maiuri
    • , Maxime Wery
    • , Mabel San Roman
    • , Léa Savey
    • , Maxime Touzot
    • , Benjamin Terrier
    • , David Saadoun
    • , Curdin Conrad
    • , Michel Gilliet
    • , Antonin Morillon
    •  & Vassili Soumelis
  • Article |

    Host cells display ‘don’t eat me’ signals to protect themselves from phagocytosis. Maute and colleagues identify a novel ‘don’t eat me’ system based on recognition of MHC class I by the phagocyte-expressed inhibitory molecule LILRB1.

    • Amira A. Barkal
    • , Kipp Weiskopf
    • , Kevin S. Kao
    • , Sydney R. Gordon
    • , Benyamin Rosental
    • , Ying Y. Yiu
    • , Benson M. George
    • , Maxim Markovic
    • , Nan G. Ring
    • , Jonathan M. Tsai
    • , Kelly M. McKenna
    • , Po Yi Ho
    • , Robin Z. Cheng
    • , James Y. Chen
    • , Layla J. Barkal
    • , Aaron M. Ring
    • , Irving L. Weissman
    •  & Roy L. Maute
  • Article |

    Vyas and colleagues show that a continuum of hemopoietic progenitor cells from human cord blood execute lymphoid and myeloid differentiation.

    • Dimitris Karamitros
    • , Bilyana Stoilova
    • , Zahra Aboukhalil
    • , Fiona Hamey
    • , Andreas Reinisch
    • , Marina Samitsch
    • , Lynn Quek
    • , Georg Otto
    • , Emmanouela Repapi
    • , Jessica Doondeea
    • , Batchimeg Usukhbayar
    • , Julien Calvo
    • , Stephen Taylor
    • , Nicolas Goardon
    • , Emmanuelle Six
    • , Francoise Pflumio
    • , Catherine Porcher
    • , Ravindra Majeti
    • , Berthold Göttgens
    •  & Paresh Vyas