Volume 18 Issue 8, August 2017

Volume 18 Issue 8

This month's Focus features a series of specially commissioned articles that discuss the most recent progress in understanding the tissue-specific characteristics and the mechanistic and genetic bases of inflammation, as well as the influence of microbiota and nutrition. See http://www.nature.com/ni/focus/inflammation2017.html. Artwork by Lewis Long.

Editorial

Comment

  • Comment |

    Netea and colleagues provide a general guide to the cellular and humoral contributors to inflammation as well as the pathways that characterize inflammation in specific organs and tissues.

    • Mihai G Netea
    • , Frances Balkwill
    • , Michel Chonchol
    • , Fabio Cominelli
    • , Marc Y Donath
    • , Evangelos J Giamarellos-Bourboulis
    • , Douglas Golenbock
    • , Mark S Gresnigt
    • , Michael T Heneka
    • , Hal M Hoffman
    • , Richard Hotchkiss
    • , Leo A B Joosten
    • , Daniel L Kastner
    • , Martin Korte
    • , Eicke Latz
    • , Peter Libby
    • , Thomas Mandrup-Poulsen
    • , Alberto Mantovani
    • , Kingston H G Mills
    • , Kristen L Nowak
    • , Luke A O'Neill
    • , Peter Pickkers
    • , Tom van der Poll
    • , Paul M Ridker
    • , Joost Schalkwijk
    • , David A Schwartz
    • , Britta Siegmund
    • , Clifford J Steer
    • , Herbert Tilg
    • , Jos W M van der Meer
    • , Frank L van de Veerdonk
    •  & Charles A Dinarello

Reviews

News and Views

  • News & Views |

    The infiltration of solid tumors by CD8+ T cells is a favorable prognostic marker. Large-scale transcriptome analysis of tumor-infiltrating T cells from mucosal tumors shows that CD8+ T cells with a CD103+ tissue-resident memory T cell phenotype might be the most desirable.

    • Derk Amsen
    • , Pleun Hombrink
    •  & Rene A W van Lier
  • News & Views |

    Lineage bias among early hematopoietic progenitor cells is specified by transcription-factor programming, and lineage switching reduces the quantity of cells produced.

    • Alberto Yáñez
    • , Helen S Goodridge
    •  & H Leighton Grimes
  • News & Views |

    Uncoupling of activation of Fc receptors via a mutant IgG1 Fc domain shows a direct role for complement receptors in antibody-dependent tumor killing.

    • Cees E van der Poel
    •  & Michael C Carroll

Research Highlights

Articles

  • Article |

    Liu and colleagues show that specification of the dendritic-cell lineage occurs in parallel with specification of the myeloid and lymphoid lineages in or around the hematopoietic-stem-cell stage, starting as a lineage bias defined by transcriptional programs that correlate with the combinatorial dose of IRF8 and PU.1.

    • Jaeyop Lee
    • , Yu Jerry Zhou
    • , Wenji Ma
    • , Wanwei Zhang
    • , Arafat Aljoufi
    • , Thomas Luh
    • , Kimberly Lucero
    • , Deguang Liang
    • , Matthew Thomsen
    • , Govind Bhagat
    • , Yufeng Shen
    •  & Kang Liu
  • Article |

    Monoclonal antibody (mAb) therapy is now commonplace in the clinic, yet such reagents can elicit unwanted side effects due to interactions with Fcγ receptors. Georgiou and colleagues have engineered mAbs that lack such FcγR interactions but retain the ability to activate complement and show that these modified mAbs have efficacious effector function.

    • Chang-Han Lee
    • , Gabrielle Romain
    • , Wupeng Yan
    • , Makiko Watanabe
    • , Wissam Charab
    • , Biliana Todorova
    • , Jiwon Lee
    • , Kendra Triplett
    • , Moses Donkor
    • , Oana I Lungu
    • , Anja Lux
    • , Nicholas Marshall
    • , Margaret A Lindorfer
    • , Odile Richard-Le Goff
    • , Bianca Balbino
    • , Tae Hyun Kang
    • , Hidetaka Tanno
    • , George Delidakis
    • , Corrine Alford
    • , Ronald P Taylor
    • , Falk Nimmerjahn
    • , Navin Varadarajan
    • , Pierre Bruhns
    • , Yan Jessie Zhang
    •  & George Georgiou
  • Article |

    Various intracellular pathogens attempt to hide from innate cytosolic sensors by forming vacuoles. Yamamoto and colleagues show that the autophagy-related protein Gate-16, which is induced by interferon-γ, is required for noncanonical autophagy to control infection by Toxoplasma gondii.

    • Miwa Sasai
    • , Naoya Sakaguchi
    • , Ji Su Ma
    • , Shuhei Nakamura
    • , Tsuyoshi Kawabata
    • , Hironori Bando
    • , Youngae Lee
    • , Tatsuya Saitoh
    • , Shizuo Akira
    • , Akiko Iwasaki
    • , Daron M Standley
    • , Tamotsu Yoshimori
    •  & Masahiro Yamamoto
  • Article |

    Expression of a competent Igh heavy chain initiates a pre-BCR checkpoint during B cell development. Reth and colleagues show that protein arginine methylation by a BTG2-PRMT1 complex is required to inactivate CDK4 and thereby establish pre-B cell arrest.

    • Elmar Dolezal
    • , Simona Infantino
    • , Friedel Drepper
    • , Theresa Börsig
    • , Aparajita Singh
    • , Thomas Wossning
    • , Gina J Fiala
    • , Susana Minguet
    • , Bettina Warscheid
    • , David M Tarlinton
    • , Hassan Jumaa
    • , David Medgyesi
    •  & Michael Reth
  • Article |

    Germinal centers generate high-affinity memory B cells. Qi and colleagues identify a precursor of memory B cells in germinal centers and demonstrate that the cytokine IL-9-derived from follicular helper T cells is important for their development into full-fledged memory cells.

    • Yifeng Wang
    • , Jingwen Shi
    • , Jiacong Yan
    • , Zhengtao Xiao
    • , Xiaoxiao Hou
    • , Peiwen Lu
    • , Shiyue Hou
    • , Tianyang Mao
    • , Wanli Liu
    • , Yuanwu Ma
    • , Lianfeng Zhang
    • , Xuerui Yang
    •  & Hai Qi
  • Article |

    Xue and colleagues show that Runx3−/− CD8+ T effector cells aberrantly upregulate genes characteristic of TFH cell lineage and exhibit impaired induction of cytotoxic molecules.

    • Qiang Shan
    • , Zhouhao Zeng
    • , Shaojun Xing
    • , Fengyin Li
    • , Stacey M Hartwig
    • , Jodi A Gullicksrud
    • , Samarchith P Kurup
    • , Natalija Van Braeckel-Budimir
    • , Yao Su
    • , Matthew D Martin
    • , Steven M Varga
    • , Ichiro Taniuchi
    • , John T Harty
    • , Weiqun Peng
    • , Vladimir P Badovinac
    •  & Hai-Hui Xue
  • Article |

    Vijayanand and colleagues use genome-wide RNA sequencing for transcriptional profiling of CD8+ T cells from tumors and adjacent uninvolved lung tissue from patients with early-stage lung cancer. A tissue-resident memory signature is associated with enhanced cytotoxicity and improved survival.

    • Anusha-Preethi Ganesan
    • , James Clarke
    • , Oliver Wood
    • , Eva M Garrido-Martin
    • , Serena J Chee
    • , Toby Mellows
    • , Daniela Samaniego-Castruita
    • , Divya Singh
    • , Grégory Seumois
    • , Aiman Alzetani
    • , Edwin Woo
    • , Peter S Friedmann
    • , Emma V King
    • , Gareth J Thomas
    • , Tilman Sanchez-Elsner
    • , Pandurangan Vijayanand
    •  & Christian H Ottensmeier

Corrigenda

Errata