Volume 18 Issue 11, November 2017

Volume 18 Issue 11

Tumor blood vessels act as a barrier to lymphocytic infiltration. Ganss and colleagues (p 1207) show that after being targeted by the cytokine LIGHT, angiogenic vasculature was modified and tertiary lymphoid structures were induced. Original image by Anna Johansson-Percival shows tumor blood vessels (green) and high endothelial venules (red) after intratumoral LIGHT therapy. Artwork by Lewis Long.

Meeting Report

  • Meeting Report |

    The US National Institutes of Health convened a workshop on disease-promoting chronic inflammation to identify the challenges and needs in the development of clinically feasible strategies for monitoring a person's inflammation status before, during and after disease occurrence.

    • Christina H Liu
    • , Natalie D Abrams
    • , Danielle M Carrick
    • , Preethi Chander
    • , Johanna Dwyer
    • , Michelle R J Hamlet
    • , Francesca Macchiarini
    • , Mercy PrabhuDas
    • , Grace L Shen
    • , Pushpa Tandon
    •  & Merriline M Vedamony

News and Views

  • News & Views |

    By switching its partners, FoxP3 segregates into functional and non-functional transcriptional complexes.

    • David Bending
    •  & Masahiro Ono
  • News & Views |

    The differentiation of follicular regulatory T cells can be limited by the cytokine IL-2, preventing the emergence of autoantibodies. This research identifies these cells as key regulators of the germinal center response.

    • Michelle A Linterman
    •  & Kai-Michael Toellner
  • News & Views |

    Dysfunctional immunity is associated with dengue hemorrhagic fever and dengue shock syndrome. Structural analyses reveal that a key germline-encoded contact between the T cell antigen receptor and a peptide underpins the immunodominance of dengue-virus-specific CD8+ T cell responses of weak affinity.

    • Sydney Blevins
    •  & Eric S Huseby

Research Highlights

Perspective

  • Perspective |

    Recent decades have seen an alarming rise in the incidence of autoimmune disease. In a Perspective, Matarese and colleagues discuss the evidence showing that changes in diet and metabolic workload can account for, at least in part, rises in the frequency of autoimmune disease.

    • Veronica De Rosa
    • , Antonio La Cava
    •  & Giuseppe Matarese

Articles

  • Article |

    NK cells are cytotoxic cells that combat tumors and viral infection. Finlay and colleagues show that the effector function of cytokine-activated NK cells depends on glucose metabolism via the citrate–malate shuttle that requires the metabolic regulator Srebp.

    • Nadine Assmann
    • , Katie L O'Brien
    • , Raymond P Donnelly
    • , Lydia Dyck
    • , Vanessa Zaiatz-Bittencourt
    • , Róisín M Loftus
    • , Paul Heinrich
    • , Peter J Oefner
    • , Lydia Lynch
    • , Clair M Gardiner
    • , Katja Dettmer
    •  & David K Finlay
  • Article |

    T cells developing in the thymus are signaled during positive selection to differentiate into either CD4+ T cells or CD8+ T cells. Singer and colleagues show that CD8+-lineage specification is signaled exclusively by cytokines, including cytokines that do not signal via the γc receptor, and that these are the only signals in the thymus that upregulate the transcription factor Runx3d to direct specification to the CD8+ lineage.

    • Ruth Etzensperger
    • , Tejas Kadakia
    • , Xuguang Tai
    • , Amala Alag
    • , Terry I Guinter
    • , Takeshi Egawa
    • , Batu Erman
    •  & Alfred Singer
  • Article |

    Cross-reactivity to dengue virus serotypes can trigger life-threatening inflammation. Culshaw et al. show that germline-encoded components of dengue-virus-specific TCRs influence antigen engagament and suggest that ‘innate-like’ recognition of the virus might underpin harmful cross-reactivity.

    • Abigail Culshaw
    • , Kristin Ladell
    • , Stephanie Gras
    • , James E McLaren
    • , Kelly L Miners
    • , Carine Farenc
    • , Heleen van den Heuvel
    • , Emma Gostick
    • , Wanwisa Dejnirattisai
    • , Apirath Wangteeraprasert
    • , Thaneeya Duangchinda
    • , Pojchong Chotiyarnwong
    • , Wannee Limpitikul
    • , Sirijitt Vasanawathana
    • , Prida Malasit
    • , Tao Dong
    • , Jamie Rossjohn
    • , Juthathip Mongkolsapaya
    • , David A Price
    •  & Gavin R Screaton
  • Article |

    Humoral immunity is necessary for controlling viral infection. Ballesteros-Tato and colleagues show that development of follicular regulatory T cells is prevented by high concentrations of interleukin 2 at the peak of viral infection, but resumes at later time points to suppress autoantibody production.

    • Davide Botta
    • , Michael J Fuller
    • , Tatiana T Marquez-Lago
    • , Holly Bachus
    • , John E Bradley
    • , Amy S Weinmann
    • , Allan J Zajac
    • , Troy D Randall
    • , Frances E Lund
    • , Beatriz León
    •  & André Ballesteros-Tato
  • Article |

    Diamond, Screaton and colleagues show that certain cross-reactive neutralizing antibodies to dengue virus have therapeutic activity against Zika virus infection in immune-privileged sites in vivo.

    • Estefania Fernandez
    • , Wanwisa Dejnirattisai
    • , Bin Cao
    • , Suzanne M Scheaffer
    • , Piyada Supasa
    • , Wiyada Wongwiwat
    • , Prabagaran Esakky
    • , Andrea Drury
    • , Juthathip Mongkolsapaya
    • , Kelle H Moley
    • , Indira U Mysorekar
    • , Gavin R Screaton
    •  & Michael S Diamond

Addendum

Addendum

Corrigenda

Erratum