Volume 17 Issue 9, September 2016

Volume 17 Issue 9

The contribution of stromal cells to the microenvironment of tumor-draining lymph nodes is poorly characterized. By comparative transcriptional analysis, Shields and colleagues (p 1118) find that tumors induce stromal reprogramming of key pathways that affect the structure and function of such lymph nodes. The original immunofluorescence image shows a resting lymph node with collagen-I-secreting stromal cells (blue), T cells (green) and B cells (red). Artwork by Lewis Long.

News and Views

  • News & Views |

    Membrane immunoglobulin E (IgE) on germinal-center-like B cells, without engagement of IgE, uses the CD19-PI3K-Akt-IRF4 axis and the BLNK-Jnk-p38 axis, with the former used for plasma-cell differentiation and the latter used for apoptotic death.

    • Toshiaki Kawakami
  • News & Views |

    Open conformers of the non-classical and monomorphic major histocompatibility complex (MHC) class I molecule HLA-F are ligands for the activating receptor KIR3DS1 and trigger the activation of natural killer (NK) cells.

    • Frédéric Vély
    • , Rachel Golub
    •  & Eric Vivier

Research Highlights

Reviews

  • Review Article |

    There is now a major effort to fully exploit the anti-tumor properties of NK cells in the clinic. In this Review, Smyth and colleagues detail recent advances in NK cell–based immunotherapies and discuss the advantages and limitations of these strategies.

    • Camille Guillerey
    • , Nicholas D Huntington
    •  & Mark J Smyth

Articles

  • Article |

    Garaude and colleagues show that innate immunological sensing of live bacteria by macrophages elicits transient adaptations to the electron-transport chain of mitochondria.

    • Johan Garaude
    • , Rebeca Acín-Pérez
    • , Sarai Martínez-Cano
    • , Michel Enamorado
    • , Matteo Ugolini
    • , Estanislao Nistal-Villán
    • , Sandra Hervás-Stubbs
    • , Pablo Pelegrín
    • , Leif E Sander
    • , José A Enríquez
    •  & David Sancho
  • Article |

    Variants of the human gene C13orf31 (LACC1) are associated with various disease risks. Kaser and colleagues identify a role for the protein encoded (called ‘FAMIN’) in regulating macrophage fatty-acid oxidation and lipogenesis.

    • M Zaeem Cader
    • , Katharina Boroviak
    • , Qifeng Zhang
    • , Ghazaleh Assadi
    • , Sarah L Kempster
    • , Gavin W Sewell
    • , Svetlana Saveljeva
    • , Jonathan W Ashcroft
    • , Simon Clare
    • , Subhankar Mukhopadhyay
    • , Karen P Brown
    • , Markus Tschurtschenthaler
    • , Tim Raine
    • , Brendan Doe
    • , Edwin R Chilvers
    • , Jules L Griffin
    • , Nicole C Kaneider
    • , R Andres Floto
    • , Mauro D'Amato
    • , Allan Bradley
    • , Michael J O Wakelam
    • , Gordon Dougan
    •  & Arthur Kaser
  • Article |

    The activating NK cell receptor KIR3DS1 has been linked to the outcome of various human diseases, yet a ligand that would account for its biological effects has remained unknown. Altfeld and colleagues establish HLA-F as a ligand of KIR3DS1, which helps to explain the widespread influence of this receptor in disease.

    • Wilfredo F Garcia-Beltran
    • , Angelique Hölzemer
    • , Gloria Martrus
    • , Amy W Chung
    • , Yovana Pacheco
    • , Camille R Simoneau
    • , Marijana Rucevic
    • , Pedro A Lamothe-Molina
    • , Thomas Pertel
    • , Tae-Eun Kim
    • , Haley Dugan
    • , Galit Alter
    • , Julie Dechanet-Merville
    • , Stephanie Jost
    • , Mary Carrington
    •  & Marcus Altfeld
  • Article |

    The kinase WNK1 is part of a pathway that controls the uptake of ions into kidney cells. Tybulewicz and colleagues show that a related pathway involving WNK1 also operates in T cells, in which it negatively regulates adhesion and positively regulates migration.

    • Robert Köchl
    • , Flavian Thelen
    • , Lesley Vanes
    • , Tiago F Brazão
    • , Kathryn Fountain
    • , Jian Xie
    • , Chou-Long Huang
    • , Ruth Lyck
    • , Jens V Stein
    •  & Victor L J Tybulewicz
  • Article |

    Autoimmunity can often be associated with prior infection. Blander and colleagues demonstrate a mechanism by which self-tolerance can be broken after the presentation of antigens derived from bacteria-infected apoptotic cells.

    • Laura Campisi
    • , Gaetan Barbet
    • , Yi Ding
    • , Enric Esplugues
    • , Richard A Flavell
    •  & J Magarian Blander
  • Article |

    Regulatory T cells (Treg cells) have essential roles in maintaining immunohomeostasis. Palmer and colleagues identify two distinct subsets of Treg cells with differing degrees of self-reactivity and regulatory function.

    • Lena Wyss
    • , Brian D Stadinski
    • , Carolyn G King
    • , Sonja Schallenberg
    • , Nicholas I McCarthy
    • , Jun Young Lee
    • , Karsten Kretschmer
    • , Luigi M Terracciano
    • , Graham Anderson
    • , Charles D Surh
    • , Eric S Huseby
    •  & Ed Palmer
  • Article |

    Infection with Zika virus has occurred in areas previously exposed to dengue virus, a closely related flavivirus. Screaton and colleagues find that monoclonal antibodies to dengue virus cross-react with Zika virus and enhance infection.

    • Wanwisa Dejnirattisai
    • , Piyada Supasa
    • , Wiyada Wongwiwat
    • , Alexander Rouvinski
    • , Giovanna Barba-Spaeth
    • , Thaneeya Duangchinda
    • , Anavaj Sakuntabhai
    • , Van-Mai Cao-Lormeau
    • , Prida Malasit
    • , Felix A Rey
    • , Juthathip Mongkolsapaya
    •  & Gavin R Screaton
  • Article |

    Under normal conditions, IgE+ memory B cells and IgE serum antibody are extremely scarce. Kitamura and colleagues demonstrate that the IgE B cell receptor has unique signaling properties that autonomously control IgE+ B cell numbers.

    • Kei Haniuda
    • , Saori Fukao
    • , Tadahiro Kodama
    • , Hitoshi Hasegawa
    •  & Daisuke Kitamura

Resource

  • Resource |

    The contribution of stromal cells to the microenvironment of tumor-draining lymph nodes is poorly characterized. By comparative transcriptional analysis, Shields and colleagues find that tumors induce the stromal reprogramming of key pathways that affect the structure and function of such lymph nodes.

    • Angela Riedel
    • , David Shorthouse
    • , Lisa Haas
    • , Benjamin A Hall
    •  & Jacqueline Shields