Volume 15 Issue 9, September 2014

Volume 15 Issue 9

This month's Focus features a series of three specially commissioned Reviews and a Perspective that provide an in-depth analysis of signaling via the T cell antigen receptor and its regulation, as well as the functional consequences of the T cell antigen receptor's recognition of peptides presented on major histocompatibility complex molecules. See http://www.nature.com/ni/focus/TCRsignaling/index.htmlArtwork by Lewis Long depicts a TCR.


  • Editorial |

    Ligation of the TCR initiates multiple signaling cascades that direct the fate of thymocytes and T cells.


  • Perspective |

    TCR ligation activates multiple downstream pathways that lead to myriad functional outputs. Malissen and colleagues discuss how unbiased mass spectrometry using signaling hub 'bait' molecules, such as Lat, provides new insight into TCR signaling cascades.

    • Bernard Malissen
    • , Claude Grégoire
    • , Marie Malissen
    •  & Romain Roncagalli


  • Review Article |

    How agonist peptides initiate the T cell antigen receptor (TCR) signaling cascade is widely debated. Weiss and Chakraborty discuss current models of the proximal signaling events that ensue upon recognition of agonist peptide–MHC complexes by TCRs.

    • Arup K Chakraborty
    •  & Arthur Weiss
  • Review Article |

    TCR engagement triggers activation of downstream kinases. Navarro and Cantrell discuss how the network of serine/threonine kinases instruct T cell metabolism to participate in immune responses.

    • María N Navarro
    •  & Doreen A Cantrell

Research Highlights


News and Views

  • News & Views |

    A ligand and G protein–coupled receptor activate antimicrobial gene expression in the Caenorhabditis elegans epidermis, in response to wounding and to infection with a fungal pathogen.

    • Robert J Luallen
    •  & Emily R Troemel
  • News & Views |

    AP4, a transcription factor induced by the functionally related transcription factor c-Myc, maintains the cellular metabolic program for the sustained activation and population expansion of CD8+ T cells after the dynamic loss of c-Myc expression.

    • Peer W F Karmaus
    •  & Hongbo Chi
  • News & Views |

    The unfolded protein response produces modified endogenous RNA substrates for host cytosolic sensors of RNA, which may lead to production of the interferons IFN-α and IFN-β. The accrual of modified RNA is prevented by an RNA nuclease.

    • Yaming Wang
    •  & Marco Colonna





  • Focus |

    TCR Signaling

    T cell development and effector function depends on signaling initiated via the T cell antigen receptor (TCR). Nature Immunologypresents a focus on TCR signaling with four specially commissioned Review and Perspective articles.