Volume 15 Issue 7, July 2014

Volume 15 Issue 7

Proper trafficking of cells of the immune system and their positioning in lymphoid tissues requires chemotactic guidance. Rot and colleagues show that chemokine gradients are actively established and maintained in lymph node subcapsular sinus regions by the atypical chemokine receptor CCRL1 (p 623; and News and Views by Woodruff & Turley, p 595). Original image shows tracks of dendritic cell migration observed in vitro in response to gradients of the chemokine CCL19 shaped by CCRL1. Original image by Kathrin Werth. Artwork by Lewis Long.


  • Commentary |

    Technological advances in antigen discovery, genomics and immunological monitoring offer tremendous potential for revolutionizing vaccine development. On 5–6 February 2014, 35 leading vaccine scientists met to consider how best to harness these advances and spur innovation.

    • Wayne C Koff
    • , Ian D Gust
    •  & Stanley A Plotkin

News and Views

  • News & Views |

    The transcription factors TCF-1 and LEF-1 have diverse roles in differentiation into the CD4+ lineage through means both dependent on and independent of the transcription factor Th-POK.

    • Jayati Mookerjee-Basu
    •  & Dietmar J Kappes
  • News & Views |

    Migrating dendritic cells follow precise navigational chemokine gradients established by lymph node stromal cells through their asymmetric expression of the atypical chemokine receptor CCRL1.

    • Matthew C Woodruff
    •  & Shannon J Turley
  • News & Views |

    The pathogenesis of inflammatory bowel disease is orchestrated by specific subsets of cytokine-secreting T cells. The interleukin 9–producing subset of helper T cells contributes to the pathogenesis of inflammatory bowel disease in part by disrupting intestinal barrier function and impairing tissue-repair mechanisms.

    • Matthew M Hufford
    •  & Mark H Kaplan

Research Highlights


  • Review Article |

    Neutrophils are classically known for their role as efficient phagocytes. Nauseef and Borregaard discuss other aspects of their biology, including trafficking, phagosome heterogeneity and the production of ectosomes.

    • William M Nauseef
    •  & Niels Borregaard