Volume 15 Issue 4, April 2014

Volume 15 Issue 4

AIM2 and IFI16 are intracellular, inflammasome-activating sensors of DNA that are pivotal for the detection of viral infections. Stehlik and colleagues (p 343; and News and Views by Eisenbarth, p 311) found a previously unrecognized protein, POP3, that functions as an inhibitor of DNA-induced inflammasomes. The original image, generated by Sonal Khare and Christian Stehlik, shows a macrophage transduced with a green fluorescent protein-expressing adenovirus (green) and DNA (blue) and stained for AIM2 (magenta). Artwork by Lewis Long.


News and Views

  • News & Views |

    The PYRIN domain–only protein POP3 sets limits for activation of the AIM2 inflammasome after cytosolic double-stranded DNA is sensed.

    • Jayendra Kumar Krishnaswamy
    • , Dong Liu
    •  & Stephanie C Eisenbarth
  • News & Views |

    Innate lymphoid cells, marginal reticular cells and B cell–helper neutrophils interact to promote antibody secretion by B cells in the marginal zone of the spleen in humans and mice.

    • Gabriel D Victora
  • News & Views |

    The activation of dendritic cells by Toll-like receptors leads to a rapid enhancement in glycolysis. Glucose is metabolized to pyruvate and from there to citrate in the mitochondria, which leads ultimately to membrane biosynthesis in the endoplasmic reticulum and Golgi to support the activation of dendritic cells.

    • Luke A J O'Neill

Research Highlights


  • Perspective |

    Recent findings in the SIV-monkey model provide new evidence that stimulating effective CD8+ T cell immunity could provide protection. McMichael and Koff explore the path forward for optimizing such responses in humans.

    • Andrew J McMichael
    •  & Wayne C Koff