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Volume 15 Issue 1, January 2014

Volume 15 Issue 1

The sensing of nucleic acids is pivotal for detecting viral infections. Reinecker and colleagues (p 63) show that the microtubule-associated protein GEF-H1 is activated after the intracellular detection of nucleic acids and is required for antiviral defense against RNA viruses. The original image, generated by Hans-Christian Reinecker and Hao-Sen Chiang, shows GEF-H1 (green) and the microtubule network (red); yellow indicates colocalization of GEF-H1 and a-tubulin.Artwork by Lewis Long.

Obituary

Commentary

  • Commentary |

    To overcome the limitations of seasonal influenza virus vaccines and enhance our pandemic preparedness, influenza virus vaccines that provide universal and long-lasting protection are needed.

    • Florian Krammer
    • Peter Palese

News & Views

  • News & Views |

    Studies have linked polymorphisms near the gene encoding interferon-λ3 (IFNL3) to clearance of hepatitis C virus (HCV). One such favorable polymorphism operates by stabilizing IFNL3 mRNA via a decrease in AU-rich element–mediated decay as well as the binding of HCV-induced host microRNAs.

    • Zhigang Tian
  • News & Views |

    Plasmacytoid dendritic cells express the microRNA miR-126, which controls their survival and effector functions via the receptor VEGFR2.

    • Marina Cella
    • Giorgio Trinchieri
  • News & Views |

    Innate-like T cells are dependent on triggering via the T cell antigen receptor (TCR) for development but subsequently actively alter their TCR responsiveness to allow an innate mode of activation that no longer requires TCR signaling.

    • Tom Cupedo
    • Janneke N Samsom

Research Highlights

Review Article

  • Review Article |

    The transcription factor NF-κB is required for T cell effector function. Gerondakis and colleagues discuss the role of NF-κB in T cell development.

    • Steve Gerondakis
    • Thomas S Fulford
    • Raelene J Grumont

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