Volume 15 Issue 10, October 2014

Volume 15 Issue 10

Billions of apoptotic cells are cleared from human tissues each day, during both tissue homeostasis and the resolution of inflammation. Lemke and colleagues show that the TAM receptor tyrosine kinases Axl and Mer are specialized to function as phagocytic receptors in these two different environments (p 920). The original image is a scanning electron micrograph of an inflammatory macrophage engulfing an apoptotic cell. Original image by Anna Zagórska and Matt Joens. Artwork by Lewis Long.


News and Views

  • News & Views |

    ThPOK, the critical transcription factor for differentiation of the helper T cell lineage in the thymus, continues to function as a gatekeeper to maintain helper T cell identity by repressing the transcription factor Runx3 in mature T cells.

    • Takeshi Egawa
  • News & Views |

    Neutrophil function is perhaps best studied in bacterial infection, during which they are directly involved in pathogen killing. After helminth invasion, however, neutrophils acquire an alternative transcriptional profile that allows them to 'train' macrophages to acquire long-term protective features.

    • John R Grainger
    •  & Richard K Grencis
  • News & Views |

    The transcriptional regulator Bcl-6 represses aerobic glycolysis in CD8+ and CD4+ type 1 helper T cells.

    • Kevin Man
    •  & Axel Kallies

Research Highlights


  • Review Article |

    The ER stress response is a well-characterized process aimed at restoring ER function. Lambrecht et al. explore how ER stress can also intersect with the innate and adaptive immune response at multiple levels.

    • Sophie Janssens
    • , Bali Pulendran
    •  & Bart N Lambrecht


  • Article |

    The clearance of apoptotic cells requires recognition by members of the TAM receptor tyrosine kinase family. Lemke and colleagues show that the TAM receptors Mer and Axl have distinct functions in tolerance induction and proinflammatory responses, respectively.

    • Anna Zagórska
    • , Paqui G Través
    • , Erin D Lew
    • , Ian Dransfield
    •  & Greg Lemke
  • Article |

    Many tissue-resident macrophages are derived from embryonic precursors. Mowat and colleagues show that embryonic precursor cells seed gut tissues but at weaning transition to a bone marrow–derived macrophage population that requires continual replenishment.

    • Calum C Bain
    • , Alberto Bravo-Blas
    • , Charlotte L Scott
    • , Elisa Gomez Perdiguero
    • , Frederic Geissmann
    • , Sandrine Henri
    • , Bernard Malissen
    • , Lisa C Osborne
    • , David Artis
    •  & Allan McI Mowat
  • Article |

    The role of neutrophils in helminth infection has been relatively unclear. Gause and colleagues demonstrate that neutrophils are involved in the priming of an M2 macrophage response that mediates long-term protection against helminth infection.

    • Fei Chen
    • , Wenhui Wu
    • , Ariel Millman
    • , Joshua F Craft
    • , Eunice Chen
    • , Nirav Patel
    • , Jean L Boucher
    • , Joseph F Urban Jr
    • , Charles C Kim
    •  & William C Gause
  • Article |

    The transcription factor ThPOK promotes CD4+ T cell differentiation in the thymus. Bosselut and colleagues show that ThPOK maintains CD4+ T lineage integrity and is required for proper TH1 and TH2 differentiation.

    • Melanie S Vacchio
    • , Lie Wang
    • , Nicolas Bouladoux
    • , Andrea C Carpenter
    • , Yumei Xiong
    • , Linus C Williams
    • , Elizabeth Wohlfert
    • , Ki-Duk Song
    • , Yasmine Belkaid
    • , Paul E Love
    •  & Rémy Bosselut
  • Article |

    Cellular metabolism seems to dictate immune responses. Weinmann and colleagues show that the transcription factor Bcl-6 opposes the action of c-Myc and Hif-1α to suppress expression of genes encoding key glycolytic enzymes and transporters.

    • Kenneth J Oestreich
    • , Kaitlin A Read
    • , Sarah E Gilbertson
    • , Kenneth P Hough
    • , Paul W McDonald
    • , Veena Krishnamoorthy
    •  & Amy S Weinmann
  • Article |

    Naive B and T cells exist in discrete zones in lymph nodes. Turley and colleagues demonstrate that a distinct subset of fibroblastic reticular cells reside in B cell zones, where they sustain B cell survival by providing BAFF.

    • Viviana Cremasco
    • , Matthew C Woodruff
    • , Lucas Onder
    • , Jovana Cupovic
    • , Janice M Nieves-Bonilla
    • , Frank A Schildberg
    • , Jonathan Chang
    • , Floriana Cremasco
    • , Christopher J Harvey
    • , Kai Wucherpfennig
    • , Burkhard Ludewig
    • , Michael C Carroll
    •  & Shannon J Turley