Volume 12 Issue 9, September 2011

Volume 12 Issue 9

The chemokine receptor CCR7 is crucial for successful lymph node homing of afferent lymph—derived immune cells, as reported by Förster and colleagues (p 879). The original image shows a three-dimensional reconstruction of serial lymph node sections from mice that received intralymphatic injection of wild-type (green) and CCR7-deficient (red) dendritic cells; blue, counterstaining with antibody to immunoglobulin D. Original image by Katharina Hoffmann and Asolina Braun. Artwork by Lewis Long.

Meeting Report

News and Views

  • News & Views |

    In addition to its recognized function as an enzyme that catalyzes tryptophan, indoleamine 2,3-dioxygenase (IDO) acts as an intracellular signal transducer, in response to transforming growth factor-β (TGF-β), to induce a stably regulatory phenotype in plasmacytoid dendritic cells.

    • WanJun Chen
  • News & Views |

    Proinflammatory signaling by the interleukin 17 receptor requires the adaptor Act1. Two studies identify an additional function for Act1 and identify new participants that regulate the inflammatory effects of IL-17.

    • Michael J May
  • News & Views |

    The kinase IKKα has a well-described activating role in the noncanonical transcription factor NF-κB pathway. Evidence now suggests that IKKα also inhibits the canonical NF-κB pathway by phosphorylating the scaffold protein TAX1BP1 to promote the assembly of the A20 ubiquitin-editing complex.

    • Christiane Pelzer
    •  & Margot Thome

Research Highlights