Volume 12 Issue 8, August 2011

Volume 12 Issue 8

NF-κB is the key transcription factor that orchestrates inflammatory responses and contributes to the development of the immune system. This month's focus features a series of specially commissioned review articles to mark the 25th anniversary of the discovery of NF-κB. http://www.nature.com/ni/focus/NF-kB/index.html Artwork by Lewis Long.

Editorial

  • Editorial |

    Few proteins have had as profound an influence on immunity and biology as the transcription factor NF-κB.

Overview

  • Overview |

    NF-κB-mediated inflammatory biology can be formulated as the following five states: latency, induction, response, resolution and pathology. The first four involve carefully tuned molecular processes; pathology is the loss of control.

    • David Baltimore

Historical Commentary

  • Historical Commentary |

    Twenty-five years after its identification, the transcription factor NF-κB continues to attract intense effort from a large and diverse research community. Ranjan Sen offers a personal account of the discovery of NF-κB.

    • Ranjan Sen

Reviews

Research Highlights

News and Views

  • News & Views |

    Innate immune responses need to be tightly controlled to avoid autoimmune and inflammatory diseases. The atypical orphan nuclear receptor SHP has now been identified as a negative regulator of Toll-like receptor–induced activation of the transcription factor NF-κB.

    • Rudi Beyaert
  • News & Views |

    Systems biology has emerged as a promising research strategy that can be applied to vaccine development. This approach can lead to the identification of new mechanisms and predictors of inactivated vaccine immunogenicity.

    • Lydie Trautmann
    •  & Rafick-Pierre Sekaly

Articles

Resources

  • Resource |

    Identifying molecular predictors of effective vaccination is an important clinical and technical goal. Pulendran and colleagues use a systems biology approach to study human responses to vaccination against influenza and determine the correlates of immunogenicity.

    • Helder I Nakaya
    • , Jens Wrammert
    • , Eva K Lee
    • , Luigi Racioppi
    • , Stephanie Marie-Kunze
    • , W Nicholas Haining
    • , Anthony R Means
    • , Sudhir P Kasturi
    • , Nooruddin Khan
    • , Gui-Mei Li
    • , Megan McCausland
    • , Vibhu Kanchan
    • , Kenneth E Kokko
    • , Shuzhao Li
    • , Rivka Elbein
    • , Aneesh K Mehta
    • , Alan Aderem
    • , Kanta Subbarao
    • , Rafi Ahmed
    •  & Bali Pulendran

    Collection:

  • Resource |

    MicroRNAs are post-transcriptional regulators of gene expression. Pagani and colleagues identify specific microRNA signatures and their target genes in various human lymphoid subsets.

    • Riccardo L Rossi
    • , Grazisa Rossetti
    • , Lynn Wenandy
    • , Serena Curti
    • , Anna Ripamonti
    • , Raoul J P Bonnal
    • , Roberto Sciarretta Birolo
    • , Monica Moro
    • , Maria C Crosti
    • , Paola Gruarin
    • , Stefano Maglie
    • , Francesco Marabita
    • , Debora Mascheroni
    • , Valeria Parente
    • , Mario Comelli
    • , Emilio Trabucchi
    • , Raffaele De Francesco
    • , Jens Geginat
    • , Sergio Abrignani
    •  & Massimiliano Pagani

Addendum

Retraction

Addendum

Focus

  • Focus |

    25 Years of NF-κB

    The transcription factor NF-κB orchestrates many facets that underlie the development and homeostasis of immune system cells and the generation of immune responses. Nature Immunologypresents six specially commissioned reviews to mark the 25th anniversary of the discovery of NF-κB.