Volume 12 Issue 7, July 2011

Volume 12 Issue 7

In T cells, three distinct protein kinase C (PKC) isozymes function sequentially to induce polarization of the microtubule-organizing center toward the immunological synapse, as reported by Huse and colleagues (p 647). Original image shows the PKC substrate Marcksl1 associated with the plasma membrane (red; total internal reflection fluorescence microscopy) and the microtubule-organizing center (blue; epifluorescence microscopy) in two T cells. Marcksl1 is depleted from the plasma membrane by PKC phosphorylation. Original image by Xin Liu. Artwork by Lewis Long.

Correspondence

Meeting Reports

  • Meeting Report |

    This report describes advances in the understanding of how microbes elicit and evade immune responses and the sensing of pathogens by host cells that leads to the activation and production of intra- and extracellular signaling molecules.

    • Paul J Hertzog
    • , Ashley Mansell
    • , Ian R van Driel
    •  & Elizabeth L Hartland
  • Meeting Report |

    For 50 years, immunologists have been meeting each winter in California to discuss new findings and theories in immunology. A recurring theme this year was the continuous conversation between the innate and adaptive arms of the immune system. To mark the 50th anniversary of this meeting, some of the speakers took a look back half a century to see how far immunologists have come.

    • David C Parker

News and Views

  • News & Views |

    Although the role of adaptive immunity in asthma is well characterized, there is relatively little understanding of the contribution of innate immunity to asthma. Studies now suggest that interleukin 13 produced by innate natural helper cells in the lungs has a substantial and underappreciated role in asthma exacerbation.

    • Stephania A Cormier
    •  & Jay K Kolls
  • News & Views |

    New data show that the interferon-induced gene product IFIT1 is a sensor for 5′-triphosphorylated RNA of viral origin and that it functions within a larger IFIT complex to inhibit viral replication.

    • Andrea Ablasser
    •  & Veit Hornung
  • News & Views |

    In response to inhaled pathogens, lymphoid tissues can form in the lung. The driving force behind this organogenic process turns out to be interleukin 17–mediated activation of lung stromal cells.

    • Tom Cupedo
  • News & Views |

    The T cell antigen receptor is functionally coupled to many kinases and adaptor proteins. Analysis of the spatiotemporal organization of the T cell antigen receptor signaling cascade suggests that adaptor-containing intracellular vesicles are essential for proper signal propagation.

    • Bernard Malissen
    •  & Didier Marguet

Research Highlights

Review

  • Review Article |

    • Vanja Lazarevic
    •  & Laurie H Glimcher

Articles

  • Article |

    Type I natural killer T cells are characterized by an invariant Vα14-Jα18 T cell antigen receptor α-chain. Godfrey and colleagues describe a population of CD1d-restricted natural killer T cells that express a previously unidentified canonical Vα10-Jα50 α-chain.

    • Adam P Uldrich
    • , Onisha Patel
    • , Garth Cameron
    • , Daniel G Pellicci
    • , E Bridie Day
    • , Lucy C Sullivan
    • , Konstantinos Kyparissoudis
    • , Lars Kjer-Nielsen
    • , Julian P Vivian
    • , Benjamin Cao
    • , Andrew G Brooks
    • , Spencer J Williams
    • , Petr Illarionov
    • , Gurdyal S Besra
    • , Stephen J Turner
    • , Steven A Porcelli
    • , James McCluskey
    • , Mark J Smyth
    • , Jamie Rossjohn
    •  & Dale I Godfrey
  • Article |

    The antiviral protein IFIT1 is upregulated substantially in the cytoplasm of virus-infected cells. Superti-Furga and colleagues show that IFIT1 is part of a virus-recognition pathway that sequesters specific viral RNA.

    • Andreas Pichlmair
    • , Caroline Lassnig
    • , Carol-Ann Eberle
    • , Maria W Górna
    • , Christoph L Baumann
    • , Thomas R Burkard
    • , Tilmann Bürckstümmer
    • , Adrijana Stefanovic
    • , Sigurd Krieger
    • , Keiryn L Bennett
    • , Thomas Rülicke
    • , Friedemann Weber
    • , Jacques Colinge
    • , Mathias Müller
    •  & Giulio Superti-Furga
  • Article |

    Ectopic bronchus-associated lymphoid tissue can form in lungs after pulmonary infection. Randall and colleagues show that aerosolized lipopolysaccharide induces the formation of this tissue in neonatal mice by a process dependent on interleukin 17.

    • Javier Rangel-Moreno
    • , Damian M Carragher
    • , Maria de la Luz Garcia-Hernandez
    • , Ji Young Hwang
    • , Kim Kusser
    • , Louise Hartson
    • , Jay K Kolls
    • , Shabaana A Khader
    •  & Troy D Randall
  • Article |

    In quiescent T cells, the signaling adaptor Lat aggregates into cell-surface clusters. Gaus and colleagues demonstrate that pre-existing clusters of Lat do not participate in signaling from the T cell antigen receptor, which relies instead on recruitment of Lat from subsynaptic vesicles.

    • David J Williamson
    • , Dylan M Owen
    • , Jérémie Rossy
    • , Astrid Magenau
    • , Matthias Wehrmann
    • , J Justin Gooding
    •  & Katharina Gaus
  • Article |

    The transcriptional control of T cell exhaustion remains unclear. Wherry and colleagues show that the transcription factor T-bet regulates CD8+ T cell exhaustion and inhibitory receptor expression.

    • Charlly Kao
    • , Kenneth J Oestreich
    • , Michael A Paley
    • , Alison Crawford
    • , Jill M Angelosanto
    • , Mohammed-Alkhatim A Ali
    • , Andrew M Intlekofer
    • , Jeremy M Boss
    • , Steven L Reiner
    • , Amy S Weinmann
    •  & E John Wherry
  • Article |

    The environmental cues involved in regulating germinal center size are not fully understood. Cyster and colleagues show that the sphingosine 1-phosphate receptor S1P2 controls the survival and localization of B cells in germinal centers by antagonizing signaling by the kinase Akt and follicular chemoattractants.

    • Jesse A Green
    • , Kazuhiro Suzuki
    • , Bryan Cho
    • , L David Willison
    • , Daniel Palmer
    • , Christopher D C Allen
    • , Timothy H Schmidt
    • , Ying Xu
    • , Richard L Proia
    • , Shaun R Coughlin
    •  & Jason G Cyster