Volume 12 Issue 4, April 2011

Volume 12 Issue 4

In response to activation, regulatory T cells undergo a differentiation program that enables them to produce interleukin 10 and access nonlymphoid tissues, as shown by Kallies and colleagues (p 304; see also News and Views by Ohkura and Sakaguchi, p 283). The original image is from the animation "Fighting Infection by Clonal Selection," created at the Walter and Eliza Hall Institute by Etsuko Uno and Drew Berry, and shows lymphocyte populations of distinct antigen specificities (various colors) in the lymph node. Artwork by Lewis Long.


  • Commentary |

    Chronic inflammatory diseases represent a major challenge for both clinical research and patient care, and evidence indicates that these disorders develop as a result of complex gene-environment interactions. Better understanding of their cause-and-effect relationship is the basis for emerging proposals for therapy and prevention.

    • Harald Renz
    • , Erika von Mutius
    • , Per Brandtzaeg
    • , William O Cookson
    • , Ingo B Autenrieth
    •  & Dirk Haller

News and Views

  • News & Views |

    Analysis of the serine-threonine phosphoproteome leads to the intriguing find that phosphorylation of the histone deacetylase HDAC7 is key to cytotoxic T lymphocyte function.

    • Amnon Altman
    •  & Kok-Fai Kong
  • News & Views |

    The development and function of TCRαβ+CD8αα+ intraepithelial lymphocytes remain poorly understood. These cells are now shown to require transforming growth factor-β for development and proper expression of characteristic surface homodimers of CD8α.

    • Dietmar J Kappes
  • News & Views |

    Regulatory T cells adopt specialized differentiation programs controlled by transcription factors. The transcription factors Blimp-1 and IRF4 are now shown to be pivotal in the maturation of effector regulatory T cells.

    • Naganari Ohkura
    •  & Shimon Sakaguchi
  • News & Views |

    Helminth parasites are adept at dampening immunity. New data showing that intracellular degradative pathways are manipulated have important implications for therapy.

    • Katherine A Smith
    •  & Rick M Maizels

Research Highlights