Volume 12 Issue 2, February 2011

Volume 12 Issue 2

Eosinophils are an essential cellular component of the plasma cell survival niche in the bone marrow, as described by Berek and colleagues (p 151; see also News and Views by Brink p 115). Original immunofluorescence stain of a bone marrow section shows colocalization of eosinophils (red) and plasma cells (green). Nuclei are counterstained with the DNAintercalating dye DAPI (blue). Original image by Van Trung Chu and Sandra Zehentmeier. Artwork by Lewis Long.

Meeting Report

News and Views

  • News & Views |

    The migration of TH2 cells into allergy-affected tissue is key to maintaining the inflammatory response. CCR8-CCL8, a newly identified chemokine receptor–ligand pair, mediates the skin accumulation of TH2 cells with the specific potential to drive chronic eosinophilic inflammation.

    • Gudrun F Debes
    •  & Malissa C Diehl
  • News & Views |

    Maintenance of hematopoietic stem cells depends on a fine-tuned transcriptional network. A detailed study of the nuclear adaptor Ldb1 provides additional clues as to how hematopoietic stem cell homeostasis is controlled.

    • Eva Welinder
    •  & Cornelis Murre
  • News & Views |

    Long-lived plasma cells require a specialized bone marrow microenvironment in order to survive and produce antibody. Eosinophils make an important contribution to maintaining this survival niche.

    • Robert Brink

Research Highlights

  • Research Highlights |

    • Laurie A Dempsey
    • , Zoltan Fehervari
    •  & Ioana Visan

Perspective

Articles

  • Article |

    Ldb1 functions as a core component of various multiprotein transcription complexes. Love and co-workers show a continuous requirement for Ldb1 in the maintenance of both fetal and adult HSC.

    • LiQi Li
    • , Raja Jothi
    • , Kairong Cui
    • , Jan Y Lee
    • , Tsadok Cohen
    • , Marat Gorivodsky
    • , Itai Tzchori
    • , Yangu Zhao
    • , Sandra M Hayes
    • , Emery H Bresnick
    • , Keji Zhao
    • , Heiner Westphal
    •  & Paul E Love
  • Article |

    The biological role of 2′-O-methylation of host and viral mRNA has remained elusive. Thiel and co-workers show that this modification modulates the induction of type I interferon and sensitivity to interferon.

    • Roland Züst
    • , Luisa Cervantes-Barragan
    • , Matthias Habjan
    • , Reinhard Maier
    • , Benjamin W Neuman
    • , John Ziebuhr
    • , Kristy J Szretter
    • , Susan C Baker
    • , Winfried Barchet
    • , Michael S Diamond
    • , Stuart G Siddell
    • , Burkhard Ludewig
    •  & Volker Thiel
  • Article |

    Pathways dependent on the transcription factor NF-κB provide innate immunity against microbes. Karin and colleagues show that mice lacking the kinase IKKβ have IL-1-dependent neutrophilia. Loss of IL-1 signaling restores blood cellularity but severely compromises antimicrobial defense.

    • Li-Chung Hsu
    • , Thomas Enzler
    • , Jun Seita
    • , Anjuli M Timmer
    • , Chih-Yuan Lee
    • , Ting-Yu Lai
    • , Guann-Yi Yu
    • , Liang-Chuan Lai
    • , Vladislav Temkin
    • , Ursula Sinzig
    • , Thiha Aung
    • , Victor Nizet
    • , Irving L Weissman
    •  & Michael Karin
  • Article |

    The cellular components of the plasma cell niche in the bone marrow have remained elusive. Berek and co-workers show that eosinophils are key providers of plasma cell survival factors in the bone marrow.

    • Van Trung Chu
    • , Anja Fröhlich
    • , Gudrun Steinhauser
    • , Tobias Scheel
    • , Toralf Roch
    • , Simon Fillatreau
    • , James J Lee
    • , Max Löhning
    •  & Claudia Berek
  • Article |

    The function of the chemokine CCL8 has remained unknown. Luster and colleagues show that CCL8 has high expression in allergic skin, where it recruits CCR8+ TH2 cells with abundant IL-5 expression.

    • Sabina A Islam
    • , Daniel S Chang
    • , Richard A Colvin
    • , Mike H Byrne
    • , Michelle L McCully
    • , Bernhard Moser
    • , Sergio A Lira
    • , Israel F Charo
    •  & Andrew D Luster
  • Article |

    TH2 cells are important for allergic and antiparasitic responses. Sun and colleagues demonstrate highly selective expression of the ECM1 protein in TH2 cells and a key role for it in regulating migration.

    • Zhenhu Li
    • , Yuan Zhang
    • , Zhiduo Liu
    • , Xiaodong Wu
    • , Yuhan Zheng
    • , Zhiyun Tao
    • , Kairui Mao
    • , Jie Wang
    • , Guomei Lin
    • , Lin Tian
    • , Yongyong Ji
    • , Meiling Qin
    • , Shuhui Sun
    • , Xueliang Zhu
    •  & Bing Sun