Volume 12 Issue 11, November 2011

Volume 12 Issue 11

The kinase LRK2 in a complex with the large noncoding RNA NRON negatively regulates the transcription factor NFAT, as reported by Lenardo and colleagues (p 1063; and News and Views by Jabri and Barreiro, p 1029). Overexpression of LRK2 abrogates the nuclear translocation of NFAT1-GFP induced by ionomycin. Nuclei are counterstained with Hoechst 33342. Original image by Zhihua Liu. Artwork by Lewis Long.

Correspondence

Commentary

  • Commentary |

    Presentations are given in a variety of environments, and effective strategies can be used to improve a speaker's presenting skills.

    • Janet P Hafler

News and Views

  • News & Views |

    Type 2 cytokine–producing innate lymphoid cells are present in human and mouse lungs, where they contribute to both type 2 immune responses and tissue repair.

    • Marsha Wills-Karp
    •  & Fred D Finkelman
  • News & Views |

    The MHC class I–like molecule TL selects high-affinity effector memory T cells to man the barriers in the intestinal mucosa.

    • Cathryn Nagler
    •  & Joanna Wroblewska
  • News & Views |

    The kinase LRRK2 is a risk factor for inflammatory bowel disease. New data show that LRRK2 blocks the transport of NFAT to the nucleus and that LRRK2 deficiency results in enhanced susceptibility to experimental colitis in mice.

    • Bana Jabri
    •  & Luis B Barreiro
  • News & Views |

    How the kinase PKC-θ is targeted to the immunological synapse and is activated once there remains unclear. A targeting motif in PKC-θ and the previously unsuspected kinase GLK identified in two separate papers now explains this.

    • Michael L Dustin

Research Highlights

Review

Articles

  • Article |

    Cytokine-producing innate lymphoid cells are found at mucosal surfaces. Artis and Wherry and their colleagues show that innate 'nuocyte-like' cells accumulate in virus-infected lungs and contribute to the repair of tissues.

    • Laurel A Monticelli
    • , Gregory F Sonnenberg
    • , Michael C Abt
    • , Theresa Alenghat
    • , Carly G K Ziegler
    • , Travis A Doering
    • , Jill M Angelosanto
    • , Brian J Laidlaw
    • , Cliff Y Yang
    • , Taheri Sathaliyawala
    • , Masaru Kubota
    • , Damian Turner
    • , Joshua M Diamond
    • , Ananda W Goldrath
    • , Donna L Farber
    • , Ronald G Collman
    • , E John Wherry
    •  & David Artis
  • Article |

    Mice have lineage-negative IL-7Rα+ (innate lymphoid) cells that contribute to type 2 immunity. Spits and colleagues identify a similar CRTH2+CD161+ population in human lungs and gut that produces IL-13 after stimulation.

    • Jenny M Mjösberg
    • , Sara Trifari
    • , Natasha K Crellin
    • , Charlotte P Peters
    • , Cornelis M van Drunen
    • , Berber Piet
    • , Wytske J Fokkens
    • , Tom Cupedo
    •  & Hergen Spits
  • Article |

    The cellular sources of IL-9 in lung inflammation remain unknown. Stockinger and colleagues use an IL-9 reporter to show IL-9 production is restricted to innate lymphoid cells during papain-induced lung inflammation.

    • Christoph Wilhelm
    • , Keiji Hirota
    • , Benjamin Stieglitz
    • , Jacques Van Snick
    • , Mauro Tolaini
    • , Katharina Lahl
    • , Tim Sparwasser
    • , Helena Helmby
    •  & Brigitta Stockinger
  • Article |

    Production of MHC class I epitopes involves the proteasome and multiple peptidases. Bernstein and colleagues show that angiotensin-converting enzyme (ACE) contributes to the generation of this peptide repertoire by trimming carboxyl termini.

    • Xiao Z Shen
    • , Sandrine Billet
    • , Chentao Lin
    • , Derick Okwan-Duodu
    • , Xu Chen
    • , Aron E Lukacher
    •  & Kenneth E Bernstein
  • Article |

    Establishing effector memory cells at mucosal barriers is critical for immune protection against pathogens. Cheroutre and colleagues show that interactions between thymus leukemia antigen and CD8αα contribute to the generation of CD8αβ+ effector memory T cells.

    • Yujun Huang
    • , Yunji Park
    • , Yiran Wang-Zhu
    • , Alexandre Larange
    • , Ramon Arens
    • , Iván Bernardo
    • , Danyvid Olivares-Villagómez
    • , Dietmar Herndler-Brandstetter
    • , Ninan Abraham
    • , Beatrix Grubeck-Loebenstein
    • , Stephen P Schoenberger
    • , Luc Van Kaer
    • , Mitchell Kronenberg
    • , Michael A Teitell
    •  & Hilde Cheroutre
  • Article |

    Efficient T cell priming occurs in organized lymphoid tissues. Turley and colleagues show that activated T cells induce nitric oxide production by lymph node stromal cells, thus limiting T cell proliferation.

    • Veronika Lukacs-Kornek
    • , Deepali Malhotra
    • , Anne L Fletcher
    • , Sophie E Acton
    • , Kutlu G Elpek
    • , Prakriti Tayalia
    • , Ai-ris Collier
    •  & Shannon J Turley
  • Article |

    The kinase PKC-θ translocates to the center of the immune synapse, but the molecular basis of this interaction is unclear. Altman and colleagues identify a conserved proline-rich motif in the V3 domain of PKC-θ required for its association with CD28 and localization to the immunological synapse.

    • Kok-Fai Kong
    • , Tadashi Yokosuka
    • , Ann J Canonigo-Balancio
    • , Noah Isakov
    • , Takashi Saito
    •  & Amnon Altman