Latest Research

  • Technical Report |

    Tissue-resident memory T (TRM) cells have been studied mainly in mouse models. Schumacher and colleagues have developed an imaging technology to track in real time skin-resident human CD8+ TRM cells in situ.

    • Feline E. Dijkgraaf
    • , Tiago R. Matos
    • , Mark Hoogenboezem
    • , Mireille Toebes
    • , David W. Vredevoogd
    • , Marjolijn Mertz
    • , Bram van den Broek
    • , Ji-Ying Song
    • , Marcel B. M. Teunissen
    • , Rosalie M. Luiten
    • , Joost B. Beltman
    •  & Ton N. Schumacher
  • Article |

    High-energy diet triggers mild β cell proliferation to compensate for peripheral insulin resistance. Qi and colleagues show that TLR2 and TLR4 inhibit the diet-induced replication of β cells in mice and humans.

    • Yewei Ji
    • , Shengyi Sun
    • , Neha Shrestha
    • , Laurel B. Darragh
    • , Jun Shirakawa
    • , Yuan Xing
    • , Yi He
    • , Bethany A. Carboneau
    • , Hana Kim
    • , Duo An
    • , Minglin Ma
    • , Jose Oberholzer
    • , Scott A. Soleimanpour
    • , Maureen Gannon
    • , Chengyang Liu
    • , Ali Naji
    • , Rohit N. Kulkarni
    • , Yong Wang
    • , Sander Kersten
    •  & Ling Qi
  • Article |

    Cachexia manifests in cancer, chronic inflammation and infections. Bergthaler and colleagues show that CD8+ T cells mediate infection-associated cachexia in a manner dependent on T cell–intrinsic type I IFN signaling and antigen recognition.

    • Hatoon Baazim
    • , Martina Schweiger
    • , Michael Moschinger
    • , Haifeng Xu
    • , Thomas Scherer
    • , Alexandra Popa
    • , Suchira Gallage
    • , Adnan Ali
    • , Kseniya Khamina
    • , Lindsay Kosack
    • , Bojan Vilagos
    • , Mark Smyth
    • , Alexander Lercher
    • , Joachim Friske
    • , Doron Merkler
    • , Alan Aderem
    • , Thomas H. Helbich
    • , Mathias Heikenwälder
    • , Philipp A. Lang
    • , Rudolf Zechner
    •  & Andreas Bergthaler
  • Resource |

    Nephritis is a major cause of lupus morbidity. Putterman and colleagues use single-cell RNA sequencing on human renal and skin biopsies to describe the expression landscape associated with lupus nephritis.

    • Evan Der
    • , Hemant Suryawanshi
    • , Pavel Morozov
    • , Manjunath Kustagi
    • , Beatrice Goilav
    • , Saritha Ranabathou
    • , Peter Izmirly
    • , Robert Clancy
    • , H. Michael Belmont
    • , Mordecai Koenigsberg
    • , Michele Mokrzycki
    • , Helen Rominieki
    • , Jay A. Graham
    • , Juan P. Rocca
    • , Nicole Bornkamp
    • , Nicole Jordan
    • , Emma Schulte
    • , Ming Wu
    • , James Pullman
    • , Kamil Slowikowski
    • , Soumya Raychaudhuri
    • , Joel Guthridge
    • , Judith James
    • , Jill Buyon
    • , Thomas Tuschl
    • , Chaim Putterman
    • , Jennifer Anolik
    • , William Apruzzese
    • , Arnon Arazi
    • , Celine Berthier
    • , Michael Brenner
    • , Jill Buyon
    • , Robert Clancy
    • , Sean Connery
    • , Melissa Cunningham
    • , Maria Dall’Era
    • , Anne Davidson
    • , Evan Der
    • , Andrea Fava
    • , Chamith Fonseka
    • , Richard Furie
    • , Dan Goldman
    • , Rohit Gupta
    • , Joel Guthridge
    • , Nir Hacohen
    • , David Hildeman
    • , Paul Hoover
    • , Raymond Hsu
    • , Judith James
    • , Ruba Kado
    • , Kenneth Kalunian
    • , Diane Kamen
    • , Mattias Kretzler
    • , Holden Maecker
    • , Elena Massarotti
    • , William McCune
    • , Maureen McMahon
    • , Meyeon Park
    • , Fernanda Payan-Schober
    • , William Pendergraft
    • , Michelle Petri
    • , Mina Pichavant
    • , Chaim Putterman
    • , Deepak Rao
    • , Soumya Raychaudhuri
    • , Kamil Slowikowski
    • , Hemant Suryawanshi
    • , Thomas Tuschl
    • , Paul Utz
    • , Dia Waguespack
    • , David Wofsy
    •  & Fan Zhang
  • Article |

    Edelson and colleagues show that the transcription factor Bhlhe40 is required in a cell-intrinsic manner for the self-renewal and maintenance of large peritoneal macrophages, but not that of other tissue-resident macrophages.

    • Nicholas N. Jarjour
    • , Elizabeth A. Schwarzkopf
    • , Tara R. Bradstreet
    • , Irina Shchukina
    • , Chih-Chung Lin
    • , Stanley Ching-Cheng Huang
    • , Chin-Wen Lai
    • , Melissa E. Cook
    • , Reshma Taneja
    • , Thaddeus S. Stappenbeck
    • , Gwendalyn J. Randolph
    • , Maxim N. Artyomov
    • , Joseph F. Urban Jr
    •  & Brian T. Edelson
  • Resource |

    Defining cell types and their activation status in rheumatoid arthritis (RA) is critical to understanding this disease. Raychaudhuri and colleagues leverage several single-cell -omics approaches to define the cellular processes and pathways in the human RA joint.

    • Fan Zhang
    • , Kevin Wei
    • , Kamil Slowikowski
    • , Chamith Y. Fonseka
    • , Deepak A. Rao
    • , Stephen Kelly
    • , Susan M. Goodman
    • , Darren Tabechian
    • , Laura B. Hughes
    • , Karen Salomon-Escoto
    • , Gerald F. M. Watts
    • , A. Helena Jonsson
    • , Javier Rangel-Moreno
    • , Nida Meednu
    • , Cristina Rozo
    • , William Apruzzese
    • , Thomas M. Eisenhaure
    • , David J. Lieb
    • , David L. Boyle
    • , Arthur M. Mandelin II
    • , Jennifer Albrecht
    • , S. Louis Bridges Jr.
    • , Christopher D. Buckley
    • , Jane H. Buckner
    • , James Dolan
    • , Joel M. Guthridge
    • , Maria Gutierrez-Arcelus
    • , Lionel B. Ivashkiv
    • , Eddie A. James
    • , Judith A. James
    • , Josh Keegan
    • , Yvonne C. Lee
    • , Mandy J. McGeachy
    • , Michael A. McNamara
    • , Joseph R. Mears
    • , Fumitaka Mizoguchi
    • , Jennifer P. Nguyen
    • , Akiko Noma
    • , Dana E. Orange
    • , Mina Rohani-Pichavant
    • , Christopher Ritchlin
    • , William H. Robinson
    • , Anupamaa Seshadri
    • , Danielle Sutherby
    • , Jennifer Seifert
    • , Jason D. Turner
    • , Paul J. Utz
    • , Brendan F. Boyce
    • , Edward DiCarlo
    • , Ellen M. Gravallese
    • , Peter K. Gregersen
    • , Larry Moreland
    • , Gary S. Firestein
    • , Nir Hacohen
    • , Chad Nusbaum
    • , James A. Lederer
    • , Harris Perlman
    • , Costantino Pitzalis
    • , Andrew Filer
    • , V. Michael Holers
    • , Vivian P. Bykerk
    • , Laura T. Donlin
    • , Jennifer H. Anolik
    • , Michael B. Brenner
    •  & Soumya Raychaudhuri
  • Article |

    HIV-1 target cells employ a number of factors that restrict the production of viral progeny. Liang and colleagues identify the cell membrane-localized metalloprotease TRABD2A as a previously unknown restriction factor that acts at the late phase of infection to degrade HIV-1 Gag polyprotein.

    • Guoxin Liang
    • , Li Zhao
    • , Ying Qiao
    • , Wenqing Geng
    • , Xiaowei Zhang
    • , Mei Liu
    • , Jinxiu Dong
    • , Haibo Ding
    • , Hong Sun
    •  & Hong Shang
  • Article |

    BCR signaling in naive B cells and in GC B cells differs. Shlomchik and colleagues report that GC B cells are ‘rewired’ in their Akt activation module, increasing p-T308 over p-S473, leading to increases of negative regulators of BCR signaling and ultimately higher thresholds for BCR activation.

    • Wei Luo
    • , William Hawse
    • , Laura Conter
    • , Nikita Trivedi
    • , Florian Weisel
    • , Daniel Wikenheiser
    • , Richard T. Cattley
    •  & Mark J. Shlomchik
  • Article |

    Innate immunity protects the central nervous system against fungal pathogens. Lionakis and colleagues identify Candidalysin, a Candida virulence factor that elicits microglial expression of the cytokine IL-1β and chemokine CXCL1 and facilitates neutrophil recruitment. Alteration of this pathway impairs antifungal responses.

    • Rebecca A. Drummond
    • , Muthulekha Swamydas
    • , Vasileios Oikonomou
    • , Bing Zhai
    • , Ivy M. Dambuza
    • , Brian C. Schaefer
    • , Andrea C. Bohrer
    • , Katrin D. Mayer-Barber
    • , Sergio A. Lira
    • , Yoichiro Iwakura
    • , Scott G. Filler
    • , Gordon D. Brown
    • , Bernhard Hube
    • , Julian R. Naglik
    • , Tobias M. Hohl
    •  & Michail S. Lionakis
  • Author Correction |

    • Masaru Kanekiyo
    • , M. Gordon Joyce
    • , Rebecca A. Gillespie
    • , John R. Gallagher
    • , Sarah F. Andrews
    • , Hadi M. Yassine
    • , Adam K. Wheatley
    • , Brian E. Fisher
    • , David R. Ambrozak
    • , Adrian Creanga
    • , Kwanyee Leung
    • , Eun Sung Yang
    • , Seyhan Boyoglu-Barnum
    • , Ivelin S. Georgiev
    • , Yaroslav Tsybovsky
    • , Madhu S. Prabhakaran
    • , Hanne Andersen
    • , Wing-Pui Kong
    • , Ulrich Baxa
    • , Kathryn L. Zephir
    • , Julie E. Ledgerwood
    • , Richard A. Koup
    • , Peter D. Kwong
    • , Audray K. Harris
    • , Adrian B. McDermott
    • , John R. Mascola
    •  & Barney S. Graham
  • Article |

    Succinate is a signaling metabolite sensed extracellularly by SUNCR1. Fernandez-Veledo and colleagues show that activation of SUCNR1 promotes an anti-inflammatory phenotype in adipose-tissue macrophages in lean mice and people.

    • Noelia Keiran
    • , Victoria Ceperuelo-Mallafré
    • , Enrique Calvo
    • , Maria Isabel Hernández-Alvarez
    • , Miriam Ejarque
    • , Catalina Núñez-Roa
    • , Daniel Horrillo
    • , Elsa Maymó-Masip
    • , M. Mar Rodríguez
    • , Rosa Fradera
    • , Juan Vladimir de la Rosa
    • , Rosa Jorba
    • , Ana Megia
    • , Antonio Zorzano
    • , Gema Medina-Gómez
    • , Carolina Serena
    • , Antonio Castrillo
    • , Joan Vendrell
    •  & Sonia Fernández-Veledo
  • Review Article |

    Comprehensive immunity requires that cells sense intracellular pathogens. In their Review, Shao and colleagues describe mechanisms for the recognition of intracellular lipopolysaccharide and its essential role in responses to Gram-negative bacteria.

    • Vijay A. K. Rathinam
    • , Yue Zhao
    •  & Feng Shao
  • Resource |

    Respiratory infections are the principal cause of asthma exacerbations in children. Altman and colleagues use a systems approach to describe the pathways associated with asthma exacerbations in a cohort of inner-city children.

    • Matthew C. Altman
    • , Michelle A. Gill
    • , Elizabeth Whalen
    • , Denise C. Babineau
    • , Baomei Shao
    • , Andrew H. Liu
    • , Brett Jepson
    • , Rebecca S. Gruchalla
    • , George T. O’Connor
    • , Jacqueline A. Pongracic
    • , Carolyn M. Kercsmar
    • , Gurjit K. Khurana Hershey
    • , Edward M. Zoratti
    • , Christine C. Johnson
    • , Stephen J. Teach
    • , Meyer Kattan
    • , Leonard B. Bacharier
    • , Avraham Beigelman
    • , Steve M. Sigelman
    • , Scott Presnell
    • , James E. Gern
    • , Peter J. Gergen
    • , Lisa M. Wheatley
    • , Alkis Togias
    • , William W. Busse
    •  & Daniel J. Jackson
  • Article |

    Fibroblastic reticular cells support lymph-node function and adaptive immunity. McGeachy and colleagues show that the cytokine IL-17 is needed to trigger metabolic changes required for the proliferation and survival of these cells in reactive lymph nodes.

    • Saikat Majumder
    • , Nilesh Amatya
    • , Shankar Revu
    • , Chetan V. Jawale
    • , Dongwen Wu
    • , Natalie Rittenhouse
    • , Ashley Menk
    • , Saran Kupul
    • , Fang Du
    • , Itay Raphael
    • , Amrita Bhattacharjee
    • , Ulrich Siebenlist
    • , Timothy W. Hand
    • , Greg M. Delgoffe
    • , Amanda C. Poholek
    • , Sarah L. Gaffen
    • , Partha S. Biswas
    •  & Mandy J. McGeachy
  • Article |

    Regulatory T cells obstruct effective anti-cancer immune responses. Vignali and colleagues demonstrate that IL-10 production and IL-35 production by tumor-infiltrating regulatory T cells mediate differential and non-redundant suppressive effects on tumor-reactive cytotoxic T cells.

    • Deepali V. Sawant
    • , Hiroshi Yano
    • , Maria Chikina
    • , Qianxia Zhang
    • , Mengting Liao
    • , Chang Liu
    • , Derrick J. Callahan
    • , Zhe Sun
    • , Tao Sun
    • , Tracy Tabib
    • , Arjun Pennathur
    • , David B. Corry
    • , James D. Luketich
    • , Robert Lafyatis
    • , Wei Chen
    • , Amanda C. Poholek
    • , Tullia C. Bruno
    • , Creg J. Workman
    •  & Dario A. A. Vignali
  • Article |

    Control of macrophage activation in the lungs is essential for the prevention of tissue damage. MacDonald and colleagues show that alveolar macrophages have impaired glycolysis and are hyporesponsive during type 2 inflammation in a manner controlled by the lung environment.

    • Freya R. Svedberg
    • , Sheila L. Brown
    • , Maria Z. Krauss
    • , Laura Campbell
    • , Catherine Sharpe
    • , Maryam Clausen
    • , Gareth J. Howell
    • , Howard Clark
    • , Jens Madsen
    • , Christopher M. Evans
    • , Tara E. Sutherland
    • , Alasdair C. Ivens
    • , David J. Thornton
    • , Richard K. Grencis
    • , Tracy Hussell
    • , Danen M. Cunoosamy
    • , Peter C. Cook
    •  & Andrew S. MacDonald
  • Article |

    Neutrophils rapidly respond to bacterial and fungal infections but can cause substantial collateral tissue damage if not restrained. Rosenbauer and colleagues show that the transcription factor PU.1 serves a cell-intrinsic role to prevent over-exuberant neutrophil responses to fungal infection.

    • Josephine Fischer
    • , Carolin Walter
    • , Alexander Tönges
    • , Hanna Aleth
    • , Marta Joana Costa Jordão
    • , Mathias Leddin
    • , Verena Gröning
    • , Tabea Erdmann
    • , Georg Lenz
    • , Johannes Roth
    • , Thomas Vogl
    • , Marco Prinz
    • , Martin Dugas
    • , Ilse D. Jacobsen
    •  & Frank Rosenbauer
  • Article |

    The cytokine IL-6 controls the survival, proliferation and effector functions of lymphocytes. Jones and colleagues show that activation of CD4+ T cells leads to suppression of STAT1 activation by tyrosine phosphatases and changes the effector characteristics of memory CD4+ T cells in response to IL-6.

    • Jason P. Twohig
    • , Ana Cardus Figueras
    • , Robert Andrews
    • , Florian Wiede
    • , Benjamin C. Cossins
    • , Alicia Derrac Soria
    • , Myles J. Lewis
    • , Michael J. Townsend
    • , David Millrine
    • , Jasmine Li
    • , David G. Hill
    • , Javier Uceda Fernandez
    • , Xiao Liu
    • , Barbara Szomolay
    • , Christopher J. Pepper
    • , Philip R. Taylor
    • , Costantino Pitzalis
    • , Tony Tiganis
    • , Nigel M. Williams
    • , Gareth W. Jones
    •  & Simon A. Jones
  • Review Article |

    The skin and intestine are unique environments at the front line of the immune system. Powrie and colleagues review the distinctive adaptations acquired by regulatory T cells at these barrier surfaces.

    • Natasha Whibley
    • , Andrea Tucci
    •  & Fiona Powrie
  • Article |

    The role of IFN-λ in adaptive immunity is not well characterized. Staeheli and colleagues show that in the lungs, IFN-λ elicits production of the cytokine TSLP from M cells and that this in turn is essential for effective adaptive immunity and control of infection with influenza virus.

    • Liang Ye
    • , Daniel Schnepf
    • , Jan Becker
    • , Karolina Ebert
    • , Yakup Tanriver
    • , Valentina Bernasconi
    • , Hans Henrik Gad
    • , Rune Hartmann
    • , Nils Lycke
    •  & Peter Staeheli
  • Article |

    The central nervous system meninges have a dense network of yolk sac–derived macrophages that serve a sentinel role. McGavern and colleagues show that this meningeal niche is replenished by bone marrow–derived inflammatory monocytes, which alters meningeal immune reactions after subsequent immune challenge.

    • Rejane Rua
    • , Jane Y. Lee
    • , Alexander B. Silva
    • , Isabella S. Swafford
    • , Dragan Maric
    • , Kory R. Johnson
    •  & Dorian B. McGavern
  • Article |

    Lymph fluid carries cells, debris and viruses to draining lymph nodes. Hickman and colleagues show that large viruses can enter lymph node conduits and gain access to dendritic cells positioned deep within lymph nodes for efficient presentation of antigen to CD8+ T cells.

    • Glennys V. Reynoso
    • , Andrea S. Weisberg
    • , John P. Shannon
    • , Daniel T. McManus
    • , Lucas Shores
    • , Jeffrey L. Americo
    • , Radu V. Stan
    • , Jonathan W. Yewdell
    •  & Heather D. Hickman
  • Publisher Correction |

    • Sarah A. Dick
    • , Jillian A. Macklin
    • , Sara Nejat
    • , Abdul Momen
    • , Xavier Clemente-Casares
    • , Marwan G. Althagafi
    • , Jinmiao Chen
    • , Crystal Kantores
    • , Siyavash Hosseinzadeh
    • , Laura Aronoff
    • , Anthony Wong
    • , Rysa Zaman
    • , Iulia Barbu
    • , Rickvinder Besla
    • , Kory J. Lavine
    • , Babak Razani
    • , Florent Ginhoux
    • , Mansoor Husain
    • , Myron I. Cybulsky
    • , Clinton S. Robbins
    •  & Slava Epelman
  • Publisher Correction |

    • Giorgio Napolitani
    • , Prathiba Kurupati
    • , Karen Wei Weng Teng
    • , Malick M. Gibani
    • , Margarida Rei
    • , Anna Aulicino
    • , Lorena Preciado-Llanes
    • , Michael Thomas Wong
    • , Etienne Becht
    • , Lauren Howson
    • , Paola de Haas
    • , Mariolina Salio
    • , Christoph J. Blohmke
    • , Lars Rønn Olsen
    • , David Miguel Susano Pinto
    • , Laura Scifo
    • , Claire Jones
    • , Hazel Dobinson
    • , Danielle Campbell
    • , Helene B. Juel
    • , Helena Thomaides-Brears
    • , Derek Pickard
    • , Dirk Bumann
    • , Stephen Baker
    • , Gordon Dougan
    • , Alison Simmons
    • , Melita A. Gordon
    • , Evan William Newell
    • , Andrew J. Pollard
    •  & Vincenzo Cerundolo
  • Article |

    Macrophages can shift their cellular metabolism in response to tissue cues and infection. Pearce and colleagues show that lipopolysaccharide-activated ‘inflammatory’ macrophages become depleted of NAD+ pools and require the salvage-pathway enzyme NAMPT to sustain cellular redox balance.

    • Alanna M. Cameron
    • , Angela Castoldi
    • , David E. Sanin
    • , Lea J. Flachsmann
    • , Cameron S. Field
    • , Daniel. J. Puleston
    • , Ryan L. Kyle
    • , Annette E. Patterson
    • , Fabian Hässler
    • , Joerg M. Buescher
    • , Beth Kelly
    • , Erika L. Pearce
    •  & Edward J. Pearce
  • Technical Report |

    Determining TCR specificity represents a formidable technical barrier to the harnessing of T cell function. Kisielow and colleagues describe a novel platform for efficient determination of TCR specificities in a variety of infectious and cancer settings and in both human systems and mouse systems.

    • Jan Kisielow
    • , Franz-Josef Obermair
    •  & Manfred Kopf
  • Article |

    Shulman and colleagues show that in contrast to events in lymph nodes and spleen, in Peyer’s patches, T cells promote B cell expansion without clonal selection during pre-germinal center events.

    • Adi Biram
    • , Anneli Strömberg
    • , Eitan Winter
    • , Liat Stoler-Barak
    • , Ran Salomon
    • , Yoseph Addadi
    • , Rony Dahan
    • , Gur Yaari
    • , Mats Bemark
    •  & Ziv Shulman
  • Resource |

    Interferon-stimulated genes (ISGs) are a key component of the antiviral response. Pichlmair and colleagues generate a comprehensive ISG interactome that sheds light on their functions in antiviral responses.

    • Philipp Hubel
    • , Christian Urban
    • , Valter Bergant
    • , William M. Schneider
    • , Barbara Knauer
    • , Alexey Stukalov
    • , Pietro Scaturro
    • , Angelika Mann
    • , Linda Brunotte
    • , Heinrich H. Hoffmann
    • , John W. Schoggins
    • , Martin Schwemmle
    • , Matthias Mann
    • , Charles M. Rice
    •  & Andreas Pichlmair
  • Article |

    Removal of damaged mitochondria maintains cellular homeostasis and regulates inflammation. Qian and colleagues describe a mechanism by which intracellular bacteria such as Listeria can elicit mitophagy to enable their survival.

    • Yifan Zhang
    • , Yikun Yao
    • , Xiaoxu Qiu
    • , Guodong Wang
    • , Zheng Hu
    • , Siyuan Chen
    • , Zhengxi Wu
    • , Na Yuan
    • , Hanchao Gao
    • , Jianrong Wang
    • , Houhui Song
    • , Stephen E. Girardin
    •  & Youcun Qian
  • Article |

    Eosinophils have been described mainly in allergy settings but are increasingly appreciated as being involved in other aspects of immunity. Albert and colleagues use a clinically approved inhibitor of the dipeptidyl peptidase DPP4 to facilitate the recruitment of eosinophils to mouse tumors, where they are essential in tumor destruction.

    • Clémence Hollande
    • , Jeremy Boussier
    • , James Ziai
    • , Tamaki Nozawa
    • , Vincent Bondet
    • , Wilson Phung
    • , Binfeng Lu
    • , Darragh Duffy
    • , Valerie Paradis
    • , Vincent Mallet
    • , Gérard Eberl
    • , Wendy Sandoval
    • , Jill M. Schartner
    • , Stanislas Pol
    • , Rosa Barreira da Silva
    •  & Matthew L. Albert
  • Article |

    Exhausted cytotoxic T lymphocytes (CTLs) express the receptor PD-1 as a key signature. Haining and colleagues show that there are different ‘depths’ of exhaustion with a subset of exhausted CTLs that retain polyfunctionality and are responsive to PD-1 blockade.

    • Brian C. Miller
    • , Debattama R. Sen
    • , Rose Al Abosy
    • , Kevin Bi
    • , Yamini V. Virkud
    • , Martin W. LaFleur
    • , Kathleen B. Yates
    • , Ana Lako
    • , Kristen Felt
    • , Girish S. Naik
    • , Michael Manos
    • , Evisa Gjini
    • , Juhi R. Kuchroo
    • , Jeffrey J. Ishizuka
    • , Jenna L. Collier
    • , Gabriel K. Griffin
    • , Seth Maleri
    • , Dawn E. Comstock
    • , Sarah A. Weiss
    • , Flavian D. Brown
    • , Arpit Panda
    • , Margaret D. Zimmer
    • , Robert T. Manguso
    • , F. Stephen Hodi
    • , Scott J. Rodig
    • , Arlene H. Sharpe
    •  & W. Nicholas Haining
  • Technical Report |

    It remains difficult to distinguish cognate APC–T cell interactions in human tissue sections. Clark and colleagues have developed an imaging–machine-learning pipeline that uses deep convolutional and tuned neural networks to identify the combination of distance and cell-shape features that can discriminate between bystander human APC–T cell interactions and cognate interactions in situ.

    • Vladimir M. Liarski
    • , Adam Sibley
    • , Nicholas van Panhuys
    • , Junting Ai
    • , Anthony Chang
    • , Domenick Kennedy
    • , Maria Merolle
    • , Ronald N. Germain
    • , Maryellen L. Giger
    •  & Marcus R. Clark
  • Article |

    Stemness is crucial for the maintenance of long-term T cell memory. Gattinoni and colleagues demonstrate that the transcription factor c-Myb is essential for the establishment of a stemness program in the CD8+ T cell memory compartment.

    • Sanjivan Gautam
    • , Jessica Fioravanti
    • , Wei Zhu
    • , John B. Le Gall
    • , Philip Brohawn
    • , Neal E. Lacey
    • , Jinhui Hu
    • , James D. Hocker
    • , Nga Voong Hawk
    • , Veena Kapoor
    • , William G. Telford
    • , Devikala Gurusamy
    • , Zhiya Yu
    • , Avinash Bhandoola
    • , Hai-Hui Xue
    • , Rahul Roychoudhuri
    • , Brandon W. Higgs
    • , Nicholas P. Restifo
    • , Timothy P. Bender
    • , Yun Ji
    •  & Luca Gattinoni
  • Article |

    Cross-protective responses across all strains of influenza virus (IAV, IBV and ICV) are a key goal of universal vaccines against influenza. Kedzierska and colleagues identify cytotoxic T cells present in blood and lungs of healthy people that are directed against all strains of influenza virus.

    • Marios Koutsakos
    • , Patricia T. Illing
    • , Thi H. O. Nguyen
    • , Nicole A. Mifsud
    • , Jeremy Chase Crawford
    • , Simone Rizzetto
    • , Auda A. Eltahla
    • , E. Bridie Clemens
    • , Sneha Sant
    • , Brendon Y. Chua
    • , Chinn Yi Wong
    • , E. Kaitlynn Allen
    • , Don Teng
    • , Pradyot Dash
    • , David F. Boyd
    • , Ludivine Grzelak
    • , Weiguang Zeng
    • , Aeron C. Hurt
    • , Ian Barr
    • , Steve Rockman
    • , David C. Jackson
    • , Tom C. Kotsimbos
    • , Allen C. Cheng
    • , Michael Richards
    • , Glen P. Westall
    • , Thomas Loudovaris
    • , Stuart I. Mannering
    • , Michael Elliott
    • , Stuart G. Tangye
    • , Linda M. Wakim
    • , Jamie Rossjohn
    • , Dhanasekaran Vijaykrishna
    • , Fabio Luciani
    • , Paul G. Thomas
    • , Stephanie Gras
    • , Anthony W. Purcell
    •  & Katherine Kedzierska
  • Article |

    An intricately linked homeostasis exists between the gut microbiome and host immune system. Scheffold and colleagues show that intestinal Treg cells upregulate the transcription factor c-Maf in response to specific signals from the gut microenvironment to establish host–microbiota homeostasis.

    • Christian Neumann
    • , Jonas Blume
    • , Urmi Roy
    • , Peggy P. Teh
    • , Ajithkumar Vasanthakumar
    • , Alexander Beller
    • , Yang Liao
    • , Frederik Heinrich
    • , Teresita L. Arenzana
    • , Jason A. Hackney
    • , Celine Eidenschenk
    • , Eric J. C. Gálvez
    • , Christina Stehle
    • , Gitta A. Heinz
    • , Patrick Maschmeyer
    • , Tom Sidwell
    • , Yifang Hu
    • , Derk Amsen
    • , Chiara Romagnani
    • , Hyun-Dong Chang
    • , Andrey Kruglov
    • , Mir-Farzin Mashreghi
    • , Wei Shi
    • , Till Strowig
    • , Sascha Rutz
    • , Axel Kallies
    •  & Alexander Scheffold
  • Letter |

    Dendritic cells (DCs) have been suggested to express a functional NLRP3 inflammasome. Gerlic and colleagues demonstrate, however, that bone marrow–derived DCs completely lack NLRP3 inflammasome activity and that the bulk of splenic DCs lack or have only minimal activity.

    • Ziv Erlich
    • , Inbar Shlomovitz
    • , Liat Edry-Botzer
    • , Hadar Cohen
    • , Daniel Frank
    • , Hanqing Wang
    • , Andrew M. Lew
    • , Kate E. Lawlor
    • , Yifan Zhan
    • , James E. Vince
    •  & Motti Gerlic
  • Article |

    Antigenic variation of influenza A viruses necessitates the annual reformulation of vaccines. Kanekiyo et al. develop a mosaic nanoparticle vaccine against influenza virus that is able to elicit neutralizing antibodies that span nearly 100 years of variation of influenza A virus.

    • Masaru Kanekiyo
    • , M. Gordon Joyce
    • , Rebecca A. Gillespie
    • , John R. Gallagher
    • , Sarah F. Andrews
    • , Hadi M. Yassine
    • , Adam K. Wheatley
    • , Brian E. Fisher
    • , David R. Ambrozak
    • , Adrian Creanga
    • , Kwanyee Leung
    • , Eun Sung Yang
    • , Seyhan Boyoglu-Barnum
    • , Ivelin S. Georgiev
    • , Yaroslav Tsybovsky
    • , Madhu S. Prabhakaran
    • , Hanne Andersen
    • , Wing-Pui Kong
    • , Ulrich Baxa
    • , Kathryn L. Zephir
    • , Julie E. Ledgerwood
    • , Richard A. Koup
    • , Peter D. Kwong
    • , Audray K. Harris
    • , Adrian B. McDermott
    • , John R. Mascola
    •  & Barney S. Graham
  • Publisher Correction |

    • Leona Gabryšová
    • , Marisol Alvarez-Martinez
    • , Raphaëlle Luisier
    • , Luke S. Cox
    • , Jan Sodenkamp
    • , Caroline Hosking
    • , Damián Pérez-Mazliah
    • , Charlotte Whicher
    • , Yashaswini Kannan
    • , Krzysztof Potempa
    • , Xuemei Wu
    • , Leena Bhaw
    • , Hagen Wende
    • , Michael H. Sieweke
    • , Greg Elgar
    • , Mark Wilson
    • , James Briscoe
    • , Vicki Metzis
    • , Jean Langhorne
    • , Nicholas M. Luscombe
    •  & Anne O’Garra