Latest Research

  • Review Article |

    Terrando and colleagues review key mechanisms related to postoperative inflammation and the implications for developing perioperative neurocognitive disorders, with a focus on neuroinflammation and key cellular targets affected by surgical trauma.

    • Ting Yang
    • , Ravikanth Velagapudi
    •  & Niccolò Terrando
  • Article |

    Exploring transcriptional heterogeneity of cKit+Sca1+ HSPCs using single cell RNA-sequencing, Naik and colleagues identify a population termed ‘lymphoid primed progenitors’ as the earliest stage of lymphoid lineage commitment, marked by downregulation of the stem/myeloid transcription factor Dach1.

    • Daniela Amann-Zalcenstein
    • , Luyi Tian
    • , Jaring Schreuder
    • , Sara Tomei
    • , Dawn S. Lin
    • , Kirsten A. Fairfax
    • , Jessica E. Bolden
    • , Mark D. McKenzie
    • , Andrew Jarratt
    • , Adrienne Hilton
    • , Jacob T. Jackson
    • , Ladina Di Rago
    • , Matthew P. McCormack
    • , Carolyn A. de Graaf
    • , Olivia Stonehouse
    • , Samir Taoudi
    • , Warren S. Alexander
    • , Stephen L. Nutt
    • , Matthew E. Ritchie
    • , Ashley P. Ng
    •  & Shalin H. Naik
  • Review Article |

    Exposure to environmental pollutants can lead to immune system dysfunction with severe pathological consequences. Yamamoto and colleagues review the impact of pollutants on immune function and describe potential means to ameliorate these effects.

    • Takafumi Suzuki
    • , Takanori Hidaka
    • , Yoshito Kumagai
    •  & Masayuki Yamamoto
  • Article |

    The identity of stem-cell memory progenitor cells has been unclear. Lugli and colleagues use high-dimensional approaches to identify two new progenitor populations of human T cells—one giving rise to a functional lineage, the other to an exhausted-like one.

    • Giovanni Galletti
    • , Gabriele De Simone
    • , Emilia M. C. Mazza
    • , Simone Puccio
    • , Claudia Mezzanotte
    • , Timothy M. Bi
    • , Alexey N. Davydov
    • , Maria Metsger
    • , Eloise Scamardella
    • , Giorgia Alvisi
    • , Federica De Paoli
    • , Veronica Zanon
    • , Alice Scarpa
    • , Barbara Camisa
    • , Federico S. Colombo
    • , Achille Anselmo
    • , Clelia Peano
    • , Sara Polletti
    • , Domenico Mavilio
    • , Luca Gattinoni
    • , Shannon K. Boi
    • , Benjamin A. Youngblood
    • , Rhiannon E. Jones
    • , Duncan M. Baird
    • , Emma Gostick
    • , Sian Llewellyn-Lacey
    • , Kristin Ladell
    • , David A. Price
    • , Dmitriy M. Chudakov
    • , Evan W. Newell
    • , Monica Casucci
    •  & Enrico Lugli
  • Resource |

    CD4+ T cells are critical for effective responses to infection with the malaria parasite. Haque and colleagues use single-cell RNA sequencing and computational modeling to track T cell memory development during experimental Plasmodium infection of mice.

    • Megan S. F. Soon
    • , Hyun Jae Lee
    • , Jessica A. Engel
    • , Jasmin Straube
    • , Bryce S. Thomas
    • , Clara P. S. Pernold
    • , Lachlan S. Clarke
    • , Pawat Laohamonthonkul
    • , Rohit N. Haldar
    • , Cameron G. Williams
    • , Lianne I. M. Lansink
    • , Marcela L. Moreira
    • , Michael Bramhall
    • , Lambros T. Koufariotis
    • , Scott Wood
    • , Xi Chen
    • , Kylie R. James
    • , Tapio Lönnberg
    • , Steven W. Lane
    • , Gabrielle T. Belz
    • , Christian R. Engwerda
    • , David S. Khoury
    • , Miles P. Davenport
    • , Valentine Svensson
    • , Sarah A. Teichmann
    •  & Ashraful Haque
  • Article |

    Sanz and colleagues examine B cell subsets in a cohort of patients with COVID-19. Severely ill patients have higher frequencies of activated extrafollicular T-bet+ B cells that form antibody-secreting cells, the majority of which express germline sequences and are reminiscent of antibody responses observed in patients with systemic lupus erythematosus during flares.

    • Matthew C. Woodruff
    • , Richard P. Ramonell
    • , Doan C. Nguyen
    • , Kevin S. Cashman
    • , Ankur Singh Saini
    • , Natalie S. Haddad
    • , Ariel M. Ley
    • , Shuya Kyu
    • , J. Christina Howell
    • , Tugba Ozturk
    • , Saeyun Lee
    • , Naveenchandra Suryadevara
    • , James Brett Case
    • , Regina Bugrovsky
    • , Weirong Chen
    • , Jacob Estrada
    • , Andrea Morrison-Porter
    • , Andrew Derrico
    • , Fabliha A. Anam
    • , Monika Sharma
    • , Henry M. Wu
    • , Sang N. Le
    • , Scott A. Jenks
    • , Christopher M. Tipton
    • , Bashar Staitieh
    • , John L. Daiss
    • , Eliver Ghosn
    • , Michael S. Diamond
    • , Robert H. Carnahan
    • , James E. Crowe Jr.
    • , William T. Hu
    • , F. Eun-Hyung Lee
    •  & Ignacio Sanz
  • Article |

    Sepsis is a biphasic disease characterized by an initial inflammatory phase, followed by a prolonged immunosuppression phase. Puthalakath and colleagues utilize a CRISPR-mediated mutagenesis screen to identify TREML4 as a regulator of sepsis-induced immunosuppression.

    • Christina Nedeva
    • , Joseph Menassa
    • , Mubing Duan
    • , Chuanxin Liu
    • , Marcel Doerflinger
    • , Andrew J. Kueh
    • , Marco J. Herold
    • , Pamali Fonseka
    • , Thanh Kha Phan
    • , Pierre Faou
    • , Harinda Rajapaksha
    • , Weisan Chen
    • , Mark D. Hulett
    •  & Hamsa Puthalakath
  • Article |

    Humans with inherited defects in DOCK8 expression are prone to allergic, type 2 CD4+ T cell responses. Mandl and colleagues reveal an important role for cell death in driving such type 2 signals during infection.

    • Caitlin Schneider
    • , Connie Shen
    • , Angelica A. Gopal
    • , Todd Douglas
    • , Benjamin Forestell
    • , Keith D. Kauffman
    • , Dakota Rogers
    • , Patricio Artusa
    • , Qian Zhang
    • , Huie Jing
    • , Alexandra F. Freeman
    • , Daniel L. Barber
    • , Irah L. King
    • , Maya Saleh
    • , Paul W. Wiseman
    • , Helen C. Su
    •  & Judith N. Mandl
  • Article |

    Ho and colleagues report that mitochondrial dysfunction and impaired mitophagy triggered by the tumor microenvironment lead to subsequent epigenetic changes and cause permanent T cell exhaustion and dysfunction.

    • Yi-Ru Yu
    • , Hana Imrichova
    • , Haiping Wang
    • , Tung Chao
    • , Zhengtao Xiao
    • , Min Gao
    • , Marcela Rincon-Restrepo
    • , Fabien Franco
    • , Raphael Genolet
    • , Wan-Chen Cheng
    • , Camilla Jandus
    • , George Coukos
    • , Yi-Fan Jiang
    • , Jason W. Locasale
    • , Alfred Zippelius
    • , Pu-Ste Liu
    • , Li Tang
    • , Christoph Bock
    • , Nicola Vannini
    •  & Ping-Chih Ho
  • Article |

    SARS-CoV-2-specific CD4+ and CD8+ T cell epitopes are found in both convalescent patients and virus-naive volunteers and are indicative of heterologous recognition shared with seasonal cold viruses.

    • Annika Nelde
    • , Tatjana Bilich
    • , Jonas S. Heitmann
    • , Yacine Maringer
    • , Helmut R. Salih
    • , Malte Roerden
    • , Maren Lübke
    • , Jens Bauer
    • , Jonas Rieth
    • , Marcel Wacker
    • , Andreas Peter
    • , Sebastian Hörber
    • , Bjoern Traenkle
    • , Philipp D. Kaiser
    • , Ulrich Rothbauer
    • , Matthias Becker
    • , Daniel Junker
    • , Gérard Krause
    • , Monika Strengert
    • , Nicole Schneiderhan-Marra
    • , Markus F. Templin
    • , Thomas O. Joos
    • , Daniel J. Kowalewski
    • , Vlatka Stos-Zweifel
    • , Michael Fehr
    • , Armin Rabsteyn
    • , Valbona Mirakaj
    • , Julia Karbach
    • , Elke Jäger
    • , Michael Graf
    • , Lena-Christin Gruber
    • , David Rachfalski
    • , Beate Preuß
    • , Ilona Hagelstein
    • , Melanie Märklin
    • , Tamam Bakchoul
    • , Cécile Gouttefangeas
    • , Oliver Kohlbacher
    • , Reinhild Klein
    • , Stefan Stevanović
    • , Hans-Georg Rammensee
    •  & Juliane S. Walz
  • Article |

    The pathways controlling T follicular helper (TFH) cell development are only partially understood. Allen and colleagues demonstrate the importance of the T cell receptor, with low tonic signaling promoting TFH cell development and high tonic signaling opposing it.

    • Juliet M. Bartleson
    • , Ashley A. Viehmann Milam
    • , David L. Donermeyer
    • , Stephen Horvath
    • , Yu Xia
    • , Takeshi Egawa
    •  & Paul M. Allen
  • Resource |

    Treg cells are essential for immune homeostasis, but the transcription factors controlling their cellular identity are incompletely understood. Schumann and colleagues use pooled and arrayed CRISPR screens and scRNA-seq to describe key gene networks in human Treg cells.

    • Kathrin Schumann
    • , Siddharth S. Raju
    • , Michael Lauber
    • , Saskia Kolb
    • , Eric Shifrut
    • , Jessica T. Cortez
    • , Nikolaos Skartsis
    • , Vinh Q. Nguyen
    • , Jonathan M. Woo
    • , Theodore L. Roth
    • , Ruby Yu
    • , Michelle L. T. Nguyen
    • , Dimitre R. Simeonov
    • , David N. Nguyen
    • , Sasha Targ
    • , Rachel E. Gate
    • , Qizhi Tang
    • , Jeffrey A. Bluestone
    • , Matthew H. Spitzer
    • , Chun Jimmie Ye
    •  & Alexander Marson
  • Article |

    Luster and colleagues show that Treg cells that reside in lung mucosa can respond to IL-33 upon allergen exposure and suppress innate cell responses. IL-33-activated ST2+ Treg cells secrete IL-35, which suppresses IL-17 production by γδ T cells and lessens eosinophil recruitment into the lung.

    • Lucas D. Faustino
    • , Jason W. Griffith
    • , Rod A. Rahimi
    • , Keshav Nepal
    • , Daniel L. Hamilos
    • , Josalyn L. Cho
    • , Benjamin D. Medoff
    • , James J. Moon
    • , Dario A. A. Vignali
    •  & Andrew D. Luster
  • Article |

    BATF3 is a member of the AP-1 transcription factor family. Kastenmüller and colleagues show that BATF3 is needed to promote memory CD8+ T cell responses. Activated CD8+ T cells transiently upregulate BATF3, which in turn suppresses expression of proapoptotic BIM to promote cell survival.

    • Marco A. Ataide
    • , Karl Komander
    • , Konrad Knöpper
    • , Annika E. Peters
    • , Hao Wu
    • , Sarah Eickhoff
    • , Tea Gogishvili
    • , Justus Weber
    • , Anika Grafen
    • , Axel Kallies
    • , Natalio Garbi
    • , Hermann Einsele
    • , Michael Hudecek
    • , Georg Gasteiger
    • , Michael Hölzel
    • , Martin Vaeth
    •  & Wolfgang Kastenmüller
  • Publisher Correction |

    • Shinya Tanaka
    • , Wataru Ise
    • , Takeshi Inoue
    • , Ayako Ito
    • , Chisato Ono
    • , Yoshihito Shima
    • , Shuhei Sakakibara
    • , Manabu Nakayama
    • , Kentaro Fujii
    • , Ikuo Miura
    • , Jafar Sharif
    • , Haruhiko Koseki
    • , Pandelakis A. Koni
    • , Indu Raman
    • , Quan-Zhen Li
    • , Masato Kubo
    • , Katsunori Fujiki
    • , Ryuichiro Nakato
    • , Katsuhiko Shirahige
    • , Hiromitsu Araki
    • , Fumihito Miura
    • , Takashi Ito
    • , Eiryo Kawakami
    • , Yoshihiro Baba
    •  & Tomohiro Kurosaki
  • Article |

    Phagocytes can acquire lipids and this modulates their function in a variety of disease states, such as atherosclerosis. Ren and colleagues demonstrate that neutrophils accumulate lipids and deliver them to tumor cells, which supports their proliferation, survival and metastasis.

    • Peishan Li
    • , Ming Lu
    • , Jiayuan Shi
    • , Zheng Gong
    • , Li Hua
    • , Qing Li
    • , Bora Lim
    • , Xiang H.-F. Zhang
    • , Xiaowen Chen
    • , Sheng Li
    • , Leonard D. Shultz
    •  & Guangwen Ren
  • Author Correction |

    • Bao-cun Zhang
    • , Ramya Nandakumar
    • , Line S. Reinert
    • , Jinrong Huang
    • , Anders Laustsen
    • , Zong-liang Gao
    • , Cheng-long Sun
    • , Søren Beck Jensen
    • , Anne Troldborg
    • , Sonia Assil
    • , Martin F. Berthelsen
    • , Carsten Scavenius
    • , Yan Zhang
    • , Samuel J. Windross
    • , David Olagnier
    • , Thaneas Prabakaran
    • , Chiranjeevi Bodda
    • , Ryo Narita
    • , Yujia Cai
    • , Cong-gang Zhang
    • , Harald Stenmark
    • , Christine M. Doucet
    • , Takeshi Noda
    • , Zheng Guo
    • , Raphaela Goldbach-Mansky
    • , Rune Hartmann
    • , Zhijian J. Chen
    • , Jan J. Enghild
    • , Rasmus O. Bak
    • , Martin K. Thomsen
    •  & Søren R. Paludan
  • Article |

    Dysregulation of lung Treg cell function contributes to asthma development. Chatila and colleagues find that allergens upregulate Notch4–Hippo–Wnt signaling in Treg cells, triggering their release of GDF15 growth factor, which drives type 2 innate lymphoid cell activity and asthma.

    • Hani Harb
    • , Emmanuel Stephen-Victor
    • , Elena Crestani
    • , Mehdi Benamar
    • , Amir Massoud
    • , Ye Cui
    • , Louis-Marie Charbonnier
    • , Sena Arbag
    • , Safa Baris
    • , Amparito Cunnigham
    • , Juan Manuel Leyva-Castillo
    • , Raif S. Geha
    • , Amirhosein J. Mousavi
    • , Boris Guennewig
    • , Klaus Schmitz-Abe
    • , Constantinos Sioutas
    • , Wanda Phipatanakul
    •  & Talal A. Chatila
  • Article |

    IL-17a is an evolutionarily conserved cytokine with behavior-modulating roles in the central nervous system. Kipnis and colleagues characterize a population of meningeal γδ17 T cells that use IL-17a to elicit anxiety-like behavior through cortical glutamatergic neurons.

    • Kalil Alves de Lima
    • , Justin Rustenhoven
    • , Sandro Da Mesquita
    • , Morgan Wall
    • , Andrea Francesca Salvador
    • , Igor Smirnov
    • , Guilherme Martelossi Cebinelli
    • , Tornike Mamuladze
    • , Wendy Baker
    • , Zach Papadopoulos
    • , Maria Beatriz Lopes
    • , William Sam Cao
    • , Xinmin Simon Xie
    • , Jasmin Herz
    •  & Jonathan Kipnis
  • Article |

    The adhesion receptor CD2 plays an important role in the full activation of T cells. Dustin and colleagues show that CD2 occupies a region in the periphery of the immunological synapse where it amplifies cognate antigen signals, whereas the presence of PD-1 disrupts this effect.

    • Philippos Demetriou
    • , Enas Abu-Shah
    • , Salvatore Valvo
    • , Sarah McCuaig
    • , Viveka Mayya
    • , Audun Kvalvaag
    • , Thomas Starkey
    • , Kseniya Korobchevskaya
    • , Lennard Y. W. Lee
    • , Matthias Friedrich
    • , Elizabeth Mann
    • , Mikhail A. Kutuzov
    • , Matteo Morotti
    • , Nina Wietek
    • , Heather Rada
    • , Shamsideen Yusuf
    • , Jehan Afrose
    • , Anastasios Siokis
    • , Philip Allan
    • , Timothy Ambrose
    • , Carolina Arancibia
    • , Adam Bailey
    • , Ellie Barnes
    • , Elizabeth Bird-Lieberman
    • , Jan Bornschein
    • , Oliver Brain
    • , Barbara Braden
    • , Jane Collier
    • , Jeremy Cobbold
    • , Emma Culver
    • , James East
    • , Lucy Howarth
    • , Paul Klenerman
    • , Simon Leedham
    • , Rebecca Palmer
    • , Michael Pavlides
    • , Fiona Powrie
    • , Astor Rodrigues
    • , Jack Satsangi
    • , Alison Simmons
    • , Peter Sullivan
    • , Holm Uhlig
    • , Alissa Walsh
    • , Michael Meyer-Hermann
    • , Ahmed Ashour Ahmed
    • , David Depoil
    •  & Michael L. Dustin
  • Article |

    Williams and colleagues investigate the origin, dynamics and transcriptional profiles of aortic intima macrophages during atherosclerosis disease progression.

    • Jesse W. Williams
    • , Konstantin Zaitsev
    • , Ki-Wook Kim
    • , Stoyan Ivanov
    • , Brian T. Saunders
    • , Patricia R. Schrank
    • , Kyeongdae Kim
    • , Andrew Elvington
    • , Seung Hyeon Kim
    • , Christopher G. Tucker
    • , Mary Wohltmann
    • , Brian T. Fife
    • , Slava Epelman
    • , Maxim N. Artyomov
    • , Kory J. Lavine
    • , Bernd H. Zinselmeyer
    • , Jae-Hoon Choi
    •  & Gwendalyn J. Randolph
  • Article |

    Questions have arisen as to whether patients with severe COVID-19 disease can generate a T cell response against SARS-CoV-2. Tao Dong and colleagues report that convalescent patients with COVID-19 harbor functional memory CD4+ and CD8+ T cells that recognize multiple epitopes that span the viral proteome. CD4+ T cells predominated the memory response in patients with severe disease, whereas higher proportions of CD8+ T cells were found in patients with mild disease.

    • Yanchun Peng
    • , Alexander J. Mentzer
    • , Guihai Liu
    • , Xuan Yao
    • , Zixi Yin
    • , Danning Dong
    • , Wanwisa Dejnirattisai
    • , Timothy Rostron
    • , Piyada Supasa
    • , Chang Liu
    • , César López-Camacho
    • , Jose Slon-Campos
    • , Yuguang Zhao
    • , David I. Stuart
    • , Guido C. Paesen
    • , Jonathan M. Grimes
    • , Alfred A. Antson
    • , Oliver W. Bayfield
    • , Dorothy E. D. P. Hawkins
    • , De-Sheng Ker
    • , Beibei Wang
    • , Lance Turtle
    • , Krishanthi Subramaniam
    • , Paul Thomson
    • , Ping Zhang
    • , Christina Dold
    • , Jeremy Ratcliff
    • , Peter Simmonds
    • , Thushan de Silva
    • , Paul Sopp
    • , Dannielle Wellington
    • , Ushani Rajapaksa
    • , Yi-Ling Chen
    • , Mariolina Salio
    • , Giorgio Napolitani
    • , Wayne Paes
    • , Persephone Borrow
    • , Benedikt M. Kessler
    • , Jeremy W. Fry
    • , Nikolai F. Schwabe
    • , Malcolm G. Semple
    • , J. Kenneth Baillie
    • , Shona C. Moore
    • , Peter J. M. Openshaw
    • , M. Azim Ansari
    • , Susanna Dunachie
    • , Eleanor Barnes
    • , John Frater
    • , Georgina Kerr
    • , Philip Goulder
    • , Teresa Lockett
    • , Robert Levin
    • , Yonghong Zhang
    • , Ronghua Jing
    • , Ling-Pei Ho
    • , Eleanor Barnes
    • , Danning Dong
    • , Tao Dong
    • , Susanna Dunachie
    • , John Frater
    • , Philip Goulder
    • , Georgina Kerr
    • , Paul Klenerman
    • , Guihai Liu
    • , Andrew McMichael
    • , Giorgio Napolitani
    • , Graham Ogg
    • , Yanchun Peng
    • , Mariolina Salio
    • , Xuan Yao
    • , Zixi Yin
    • , J. Kenneth Baillie
    • , Paul Klenerman
    • , Alexander J. Mentzer
    • , Shona C. Moore
    • , Peter J. M. Openshaw
    • , Malcolm G. Semple
    • , David I. Stuart
    • , Lance Turtle
    • , Richard J. Cornall
    • , Christopher P. Conlon
    • , Paul Klenerman
    • , Gavin R. Screaton
    • , Juthathip Mongkolsapaya
    • , Andrew McMichael
    • , Julian C. Knight
    • , Graham Ogg
    •  & Tao Dong
  • Article |

    Antigen-activated B cells are short lived in the absence of a second signal provided by CD4+ T cells or cytokines. Zikherman and colleagues report that the NR4A family of nuclear receptors (NUR77 and NOR-1) are responsible for enforcing this ‘tolerance’ to self-antigen (signal 1 only) and explain, in part, why B cells are dependent upon a second signal.

    • Corey Tan
    • , Ryosuke Hiwa
    • , James L. Mueller
    • , Vivasvan Vykunta
    • , Kenta Hibiya
    • , Mark Noviski
    • , John Huizar
    • , Jeremy F. Brooks
    • , Jose Garcia
    • , Cheryl Heyn
    • , Zhongmei Li
    • , Alexander Marson
    •  & Julie Zikherman
  • Article |

    B cell development and selection occur in the often hypoxic environment of the bone marrow. Burrows and colleagues demonstrate that dynamic regulation of B cell–intrinsic hypoxia-inducible factor-1α is essential for normal B cell development and function.

    • Natalie Burrows
    • , Rachael J. M. Bashford-Rogers
    • , Vijesh J. Bhute
    • , Ana Peñalver
    • , John R. Ferdinand
    • , Benjamin J. Stewart
    • , Joscelin E. G. Smith
    • , Mukta Deobagkar-Lele
    • , Girolamo Giudice
    • , Thomas M. Connor
    • , Akimichi Inaba
    • , Laura Bergamaschi
    • , Sam Smith
    • , Maxine G. B. Tran
    • , Evangelia Petsalaki
    • , Paul A. Lyons
    • , Marion Espeli
    • , Brian J. P. Huntly
    • , Kenneth G. C. Smith
    • , Richard J. Cornall
    • , Menna R. Clatworthy
    •  & Patrick H. Maxwell
  • Article |

    Checkpoint blockade is effective in only a subset of patients; therefore, biomarkers that can predict efficacy would be clinically highly valuable. Nishkawa and colleagues develop a biomarker based on PD-1 positivity of effector and regulatory T cells in the tumor microenvironment that accurately predicts the effectiveness of checkpoint blockade in patients.

    • Shogo Kumagai
    • , Yosuke Togashi
    • , Takahiro Kamada
    • , Eri Sugiyama
    • , Hitomi Nishinakamura
    • , Yoshiko Takeuchi
    • , Kochin Vitaly
    • , Kota Itahashi
    • , Yuka Maeda
    • , Shigeyuki Matsui
    • , Takuma Shibahara
    • , Yasuho Yamashita
    • , Takuma Irie
    • , Ayaka Tsuge
    • , Shota Fukuoka
    • , Akihito Kawazoe
    • , Hibiki Udagawa
    • , Keisuke Kirita
    • , Keiju Aokage
    • , Genichiro Ishii
    • , Takeshi Kuwata
    • , Kenta Nakama
    • , Masahito Kawazu
    • , Toshihide Ueno
    • , Naoya Yamazaki
    • , Koichi Goto
    • , Masahiro Tsuboi
    • , Hiroyuki Mano
    • , Toshihiko Doi
    • , Kohei Shitara
    •  & Hiroyoshi Nishikawa
  • Article |

    NKG7 is a molecule well associated with NK cells but of unknown function. Engwerda and colleagues demonstrate that NKG7 is also associated with TH1 cells and is essential for type I and cytotoxic responses.

    • Susanna S. Ng
    • , Fabian De Labastida Rivera
    • , Juming Yan
    • , Dillon Corvino
    • , Indrajit Das
    • , Ping Zhang
    • , Rachel Kuns
    • , Shashi Bhushan Chauhan
    • , Jiajie Hou
    • , Xian-Yang Li
    • , Teija C. M. Frame
    • , Benjamin A. McEnroe
    • , Eilish Moore
    • , Jinrui Na
    • , Jessica A. Engel
    • , Megan S. F. Soon
    • , Bhawana Singh
    • , Andrew J. Kueh
    • , Marco J. Herold
    • , Marcela Montes de Oca
    • , Siddharth Sankar Singh
    • , Patrick T. Bunn
    • , Amy Roman Aguilera
    • , Mika Casey
    • , Matthias Braun
    • , Nazanin Ghazanfari
    • , Shivangi Wani
    • , Yulin Wang
    • , Fiona H. Amante
    • , Chelsea L. Edwards
    • , Ashraful Haque
    • , William C. Dougall
    • , Om Prakash Singh
    • , Alan G. Baxter
    • , Michele W. L. Teng
    • , Alex Loukas
    • , Norelle L. Daly
    • , Nicole Cloonan
    • , Mariapia A. Degli-Esposti
    • , Jude Uzonna
    • , William R. Heath
    • , Tobias Bald
    • , Siok-Keen Tey
    • , Kyohei Nakamura
    • , Geoffrey R. Hill
    • , Rajiv Kumar
    • , Shyam Sundar
    • , Mark J. Smyth
    •  & Christian R. Engwerda
  • Article |

    Takayanagi and colleagues show that thymic medullary fibroblasts can contribute to central tolerance mechanisms by expressing cell-type-specific antigens distinct from those expressed by medullary thymic epithelial cells.

    • Takeshi Nitta
    • , Masanori Tsutsumi
    • , Sachiko Nitta
    • , Ryunosuke Muro
    • , Emma C. Suzuki
    • , Kenta Nakano
    • , Yoshihiko Tomofuji
    • , Shinichiro Sawa
    • , Tadashi Okamura
    • , Josef M. Penninger
    •  & Hiroshi Takayanagi
  • Article |

    Diamond and colleagues generate a K18-hACE2 model of SARS-CoV-2 infection that shares many features of severe COVID-19 infection and can be used to define the basis of lung disease and test immune and antiviral-based countermeasures.

    • Emma S. Winkler
    • , Adam L. Bailey
    • , Natasha M. Kafai
    • , Sharmila Nair
    • , Broc T. McCune
    • , Jinsheng Yu
    • , Julie M. Fox
    • , Rita E. Chen
    • , James T. Earnest
    • , Shamus P. Keeler
    • , Jon H. Ritter
    • , Liang-I Kang
    • , Sarah Dort
    • , Annette Robichaud
    • , Richard Head
    • , Michael J. Holtzman
    •  & Michael S. Diamond
  • Article |

    The developmental timing for exhaustion is still obscure. Kallies and colleagues demonstrate that CD8+ T cell ‘exhaustion’ actually begins in the less-differentiated TCF1+ ‘precursor’ T cell pool during chronic viral infections.

    • Daniel T. Utzschneider
    • , Sarah S. Gabriel
    • , David Chisanga
    • , Renee Gloury
    • , Patrick M. Gubser
    • , Ajithkumar Vasanthakumar
    • , Wei Shi
    •  & Axel Kallies
  • Article |

    The angiocrine Rspondin3 is produced by endothelial cells (ECs) and controls growth and development. Malik and colleagues show that lung ECs produce Rspondin3 following injury and specifically direct interstitial macrophages into an anti-inflammatory and wound-healing program.

    • Bisheng Zhou
    • , Lissette Magana
    • , Zhigang Hong
    • , Long Shuang Huang
    • , Sreeparna Chakraborty
    • , Yoshikazu Tsukasaki
    • , Cary Huang
    • , Li Wang
    • , Anke Di
    • , Balaji Ganesh
    • , Xiaopei Gao
    • , Jalees Rehman
    •  & Asrar B. Malik
  • Review Article |

    Pancreatic cancer has one of the worst survival outcomes of all cancers. Leinwand and Miller review the immunological landscape of pancreatic cancer, immune evasion mechanisms and the impact of the microbiota.

    • Joshua Leinwand
    •  & George Miller
  • Article |

    Siracusa and colleagues reveal a regulatory role for basophils in the context of anti-helminth immunity and identify the neuropeptide neuromedin B as a potent inhibitor of type 2 inflammation.

    • Juan M. Inclan-Rico
    • , John J. Ponessa
    • , Nuriban Valero-Pacheco
    • , Christina M. Hernandez
    • , Chandler B. Sy
    • , Alexander D. Lemenze
    • , Aimee M. Beaulieu
    •  & Mark C. Siracusa
  • Technical Report |

    Accurate serology testing is urgently needed to help diagnose SARS-CoV-2 infection. Here Valkenburg and colleagues use a luciferase immunoprecipitation system to assess the antibody responses to 15 different SARS-CoV-2 antigens in patients with COVID-19 and find ORF8 and ORF3b antibodies, taken together as a cluster of points, identified 96.5% of COVID-19 samples at early and late time points of disease with 99.5% specificity

    • Asmaa Hachim
    • , Niloufar Kavian
    • , Carolyn A. Cohen
    • , Alex W. H. Chin
    • , Daniel K. W. Chu
    • , Chris K. P. Mok
    • , Owen T. Y. Tsang
    • , Yiu Cheong Yeung
    • , Ranawaka A. P. M. Perera
    • , Leo L. M. Poon
    • , J. S. Malik Peiris
    •  & Sophie A. Valkenburg
  • Resource |

    Severe COVID-19 is characterized—among other things—by a hyperinflammatory state. Wang and colleagues describe the single-cell transcriptional landscape of moderate, severe and convalescent cases of patients with COVID-19.

    • Ji-Yuan Zhang
    • , Xiang-Ming Wang
    • , Xudong Xing
    • , Zhe Xu
    • , Chao Zhang
    • , Jin-Wen Song
    • , Xing Fan
    • , Peng Xia
    • , Jun-Liang Fu
    • , Si-Yu Wang
    • , Ruo-Nan Xu
    • , Xiao-Peng Dai
    • , Lei Shi
    • , Lei Huang
    • , Tian-Jun Jiang
    • , Ming Shi
    • , Yuxia Zhang
    • , Alimuddin Zumla
    • , Markus Maeurer
    • , Fan Bai
    •  & Fu-Sheng Wang
  • Author Correction |

    • Takahiro Masuda
    • , Lukas Amann
    • , Roman Sankowski
    • , Ori Staszewski
    • , Maximilian Lenz
    • , Paolo d´Errico
    • , Nicolas Snaidero
    • , Marta Joana Costa Jordão
    • , Chotima Böttcher
    • , Katrin Kierdorf
    • , Steffen Jung
    • , Josef Priller
    • , Thomas Misgeld
    • , Andreas Vlachos
    • , Melanie Meyer-Luehmann
    • , Klaus-Peter Knobeloch
    •  & Marco Prinz
  • Article |

    Obesity is often accompanied by chronic inflammation. Li and colleagues show that, in mice fed high-fat diets, IL-1 signaling in adipocytes induces an unconventional IRAK2 translocation to mitochondria and suppresses respiratory super-complex formation to alter mitochondrial function, and exacerbates obesity.

    • Hao Zhou
    • , Han Wang
    • , Minjia Yu
    • , Rebecca C. Schugar
    • , Wen Qian
    • , Fangqiang Tang
    • , Weiwei Liu
    • , Hui Yang
    • , Ruth E. McDowell
    • , Junjie Zhao
    • , Ji Gao
    • , Ashok Dongre
    • , Julie A. Carman
    • , Mei Yin
    • , Judith A. Drazba
    • , Robert Dent
    • , Christopher Hine
    • , Yeong-Renn Chen
    • , Jonathan D. Smith
    • , Paul L. Fox
    • , J. Mark Brown
    •  & Xiaoxia Li
  • Article |

    Autophagy controls cellular homeostasis and influences immune responses. Galluzzi and colleagues show that tumor cell autophagy opposes inflammatory cell death following radiation therapy and can be inhibited to enhance antitumor responses.

    • Takahiro Yamazaki
    • , Alexander Kirchmair
    • , Ai Sato
    • , Aitziber Buqué
    • , Marissa Rybstein
    • , Giulia Petroni
    • , Norma Bloy
    • , Francesca Finotello
    • , Lena Stafford
    • , Esther Navarro Manzano
    • , Francisco Ayala de la Peña
    • , Elena García-Martínez
    • , Silvia C. Formenti
    • , Zlatko Trajanoski
    •  & Lorenzo Galluzzi
  • Article |

    The CTLA-4–Ig fusion protein (abatacept) can have beneficial effects in autoimmune disease. Walker and colleagues show in mouse and human type 1 diabetes that abatacept targets pathogenic follicular helper T cells, and the frequencies of these cells at baseline can be used to stratify treatment responses in patients.

    • Natalie M. Edner
    • , Frank Heuts
    • , Niclas Thomas
    • , Chun Jing Wang
    • , Lina Petersone
    • , Rupert Kenefeck
    • , Alexandros Kogimtzis
    • , Vitalijs Ovcinnikovs
    • , Ellen M. Ross
    • , Elisavet Ntavli
    • , Yassin Elfaki
    • , Martin Eichmann
    • , Roman Baptista
    • , Philip Ambery
    • , Lutz Jermutus
    • , Mark Peakman
    • , Miranda Rosenthal
    •  & Lucy S. K. Walker
  • Review Article |

    Koliaraki, Prados, Armaka & Kollias review the roles of fibroblastic mesenchymal cells in tissue homeostasis and immunopathologic diseases, including chronic inflammatory disease, tissue fibrosis and cancer.

    • Vasiliki Koliaraki
    • , Alejandro Prados
    • , Marietta Armaka
    •  & George Kollias
  • Article |

    Pathological group 2 innate lymphoid cells (ILC2s) have mainly been implicated in allergy. Halim and colleagues demonstrate that ILC2s orchestrate a prometastatic pathway via the recruitment of eosinophils that suppress NK cell function.

    • Martijn J. Schuijs
    • , Shaun Png
    • , Arianne C. Richard
    • , Anastasia Tsyben
    • , Gregory Hamm
    • , Julie Stockis
    • , Celine Garcia
    • , Silvain Pinaud
    • , Ashley Nicholls
    • , Xavier Romero Ros
    • , Jing Su
    • , Matthew D. Eldridge
    • , Angela Riedel
    • , Eva M. Serrao
    • , Hans-Reimer Rodewald
    • , Matthias Mack
    • , Jacqueline D. Shields
    • , E. Suzanne Cohen
    • , Andrew N. J. McKenzie
    • , Richard J. A. Goodwin
    • , Kevin M. Brindle
    • , John C. Marioni
    •  & Timotheus Y. F. Halim
  • Resource |

    Banchereau and colleagues provide a resource dataset that examines disease-related transcriptional profiles of peripheral whole-blood cells from adolescent patients with SLE by single-cell RNA-seq analysis.

    • Djamel Nehar-Belaid
    • , Seunghee Hong
    • , Radu Marches
    • , Guo Chen
    • , Mohan Bolisetty
    • , Jeanine Baisch
    • , Lynnette Walters
    • , Marilynn Punaro
    • , Robert J. Rossi
    • , Cheng-Han Chung
    • , Richie P. Huynh
    • , Prashant Singh
    • , William F. Flynn
    • , Joy-Ann Tabanor-Gayle
    • , Navya Kuchipudi
    • , Asuncion Mejias
    • , Magalie A. Collet
    • , Anna Lisa Lucido
    • , Karolina Palucka
    • , Paul Robson
    • , Santhanam Lakshminarayanan
    • , Octavio Ramilo
    • , Tracey Wright
    • , Virginia Pascual
    •  & Jacques F. Banchereau
  • Article |

    Kim and colleagues provide new insights into the function and fate of neutrophils during influenza infection and their roles in antiviral T cell responses.

    • Kihong Lim
    • , Tae-hyoun Kim
    • , Alissa Trzeciak
    • , Andrea M. Amitrano
    • , Emma C. Reilly
    • , Hen Prizant
    • , Deborah J. Fowell
    • , David J. Topham
    •  & Minsoo Kim
  • Resource |

    The epigenetic landscape of human αβ and γδT cell development has remained unexplored thus far. Taghon and colleagues provide a resource of RNA-seq and ATAC–seq profiles examining human thymocyte development.

    • Juliette Roels
    • , Anna Kuchmiy
    • , Matthias De Decker
    • , Steven Strubbe
    • , Marieke Lavaert
    • , Kai Ling Liang
    • , Georges Leclercq
    • , Bart Vandekerckhove
    • , Filip Van Nieuwerburgh
    • , Pieter Van Vlierberghe
    •  & Tom Taghon
  • Resource |

    Luo and colleagues use single-cell RNA sequencing to provide a comprehensive transcriptional landscape of neutrophil maturation, function and fate decision in their steady state and during bacterial infection.

    • Xuemei Xie
    • , Qiang Shi
    • , Peng Wu
    • , Xiaoyu Zhang
    • , Hiroto Kambara
    • , Jiayu Su
    • , Hongbo Yu
    • , Shin-Young Park
    • , Rongxia Guo
    • , Qian Ren
    • , Sudong Zhang
    • , Yuanfu Xu
    • , Leslie E. Silberstein
    • , Tao Cheng
    • , Fengxia Ma
    • , Cheng Li
    •  & Hongbo R. Luo
  • Article |

    Verykokakis and colleagues show that the transcription factor BCL-6 is highly expressed in stage 0 NKT and is absolutely required for innate T cell lineage development. BCL-6 acts to modify the chromatin landscape and is needed to promote the ST0–ST1 transition and PLZF expression.

    • Marianthi Gioulbasani
    • , Alexandros Galaras
    • , Sofia Grammenoudi
    • , Panagiotis Moulos
    • , Alexander L. Dent
    • , Mikael Sigvardsson
    • , Pantelis Hatzis
    • , Barbara L. Kee
    •  & Mihalis Verykokakis