News & Comment

  • News & Views |

    The transcription factor Bhlhe40 is required for the homeostatic proliferation of peritoneal macrophages and their expansion during type 2 immunity.

    • Carla V. Rothlin
    •  & Sourav Ghosh
  • News & Views |

    A novel feedback loop coordinated by germinal center–specific signaling via the kinase AKT activates negative regulators of upstream BCR signaling to attenuate responses to antigen stimulation.

    • Julie Zikherman
  • News & Views |

    Expression of the immunosuppressive cytokines IL-10 and IL-35 by tumor-infiltrating regulatory T cells drives exhaustion of intratumoral CD8+ T cells through a common pathway dependent on the transcription factor BLIMP-1.

    • Martina Damo
    •  & Nikhil S. Joshi
  • News & Views |

    The cytokine IL-17 augments metabolism in fibroblastic reticular cells in lymph nodes, which enhances their proliferation and survival to support B cell responses during autoimmunity.

    • Scott N. Mueller
  • News & Views |

    The transcription factor PU.1 is not needed for the maintenance of neutrophil identity but is essential for the prevention of excessive tissue damage due to a prolonged immune response. PU.1 restrains the activation of neutrophils by antagonizing the AP-1 transcription factor JunB.

    • Richard Dahl
  • News & Views |

    The N6-methyladenosine (m6A) RNA-modification pathway affects numerous aspects of immune responses. A new study now demonstrates that m6A modification of transcripts encoding lysosomal proteases limits the efficiency of tumor-antigen cross-presentation.

    • Marianne Burbage
    • , Marine Gros
    •  & Sebastian Amigorena
  • News & Views |

    The mechanisms by which the cytokine IFN-λ regulates adaptive immune responses are poorly understood. A new study now reveals a novel IFN-λ-mediated signal-transmission system that enhances immunity after infection of the mouse respiratory tract with influenza virus.

    • Stefan F. Wieland
    •  & Markus H. Heim
  • News & Views |

    Recent studies indicate that macrophages utilize NAD+-biosynthetic pathways to control inflammation and cell survival during the immune response and aging.

    • Leah K. Billingham
    •  & Navdeep S. Chandel
  • News & Views |

    Inflammasomes have been reported to function in a wide variety of innate immune cells; however, their activity now seems to be more restricted than previously thought.

    • Pierre Guermonprez
    •  & Julie Helft
  • News & Views |

    Members of the SLAM family of receptors promote the progression of invariant natural killer T cells through the thymic maturation process and facilitate proper host responses to exogenous lipid antigen through the recruitment and activity of SAP–Fyn and SHP-1, respectively.

    • Shankar S. Iyer
    • , Yu-Hwa Huang
    •  & Richard S. Blumberg
  • News & Views |

    Combined immunotherapy using checkpoint blockade (anti-CTLA4 and anti-PD-1) and the DPP4 inhibitor sitagliptin reveals the existence of a T cell– and eosinophil-targeted immunotherapy approach for solid tumors.

    • Ariel Munitz
    •  & Simon Patrick Hogan
  • News & Views |

    A multivalent vaccine that presents diverse influenza virus subtype H1 hemagglutinins on its surface induces broadly neutralizing antibodies in an animal model by displaying conserved epitopes at higher density than strain-specific epitopes.

    • Florian Krammer
  • News & Views |

    The transition of the fetus from the womb to the external world represents an extraordinary challenge. The generation of memory T cells before birth may serve an important role in preparation for this fundamental transition.

    • Ai Ing Lim
    • , Oliver J. Harrison
    •  & Yasmine Belkaid
  • News & Views |

    The zinc transporter ZIP7 positively regulates signaling via the BCR during early B cell development in mice and humans. Impairment of ZIP7 function results in a novel primary immunodeficiency.

    • Toshiyuki Fukada
    • , Shintaro Hojyo
    • , Takafumi Hara
    •  & Teruhisa Takagishi
  • News & Views |

    In patients with rheumatoid arthritis, decreased abundance of the N-myristoyltransferase NMT1 in CD4+ T cells prevents N-myristoylation of the AMP-activated protein kinase AMPK and its localization to the lysosomal membrane, which leads to increased activation of the metabolic checkpoint kinase complex mTORC1 and proinflammatory T cell phenotypes.

    • David K. Finlay
  • News & Views |

    A new target for controlling T cell responses adds to the list of key processes dependent on the synthesis of tetrahydrobiopterin, which is essential for neurotransmitter and nitric-oxide production and pain control.

    • Andrew L. Mellor
    •  & Lei Huang
  • News & Views |

    The N6-methyladenosine (m6A) RNA-modification pathway substantially affects the outcome of viral infection. Studies now show that m6A modification of transcripts encoding type I interferons limits the duration of anti-viral signaling.

    • Charles R. Hesser
    •  & Britt A. Glaunsinger
  • News & Views |

    Innate lymphoid cell–derived cytokine IL-13 promotes the maintenance of intestinal stem cells through stabilization of β-catenin. The circular RNA circPan3 regulates mRNA encoding the cytokine receptor subunit IL-13Rα and downstream IL-13 signaling to stabilize the β-catenin pathway in intestinal stem cells.

    • Frank Soveg
    • , Jakob von Moltke
    •  & Ram Savan
  • News & Views |

    Activation of STING requires its translocation from the endoplasmic reticulum (ER) through the Golgi to vesicles, but the mechanisms that control its localization have been unclear. The ER calcium sensor STIM1 acts as an ER-retention factor that anchors STING on the ER and limits STING signaling.

    • Jianjun Wu
    •  & Nan Yan
  • News & Views |

    The resolution of inflammation is a protective response. The identification and characterization of new players that boost this response might inform the development of novel therapies for non-resolving inflammatory diseases.

    • Gabrielle Fredman