News & Comment

  • News & Views |

    Studies of mice demonstrate a link between the female hormone estrogen and protection against bacteremia and sepsis through the induction of natural antibodies to Eshcerichia coli.

    • Joseph Chavarria-Smith
    • , Wouter L. W. Hazenbos
    •  & Menno van Lookeren Campagne
  • News & Views |

    Cell-type-specific regulation of gene expression by transcription factors is a fundamental principle of biology. New findings show that microRNA-mediated control of target-gene expression is also dependent on the cellular context.

    • Pengda Chen
    • , Kunyu Liao
    •  & Changchun Xiao
  • News & Views |

    New insights into how NK cells are educated by the receptor NKG2D, which leads to effects on another receptor, NCR1, raise interesting questions about why so many receptors are linked to the education of NK cells.

    • André Veillette
    •  & Yan Lu
  • News & Views |

    Group 2 innate lymphoid cells (ILC2s) that produce the cytokine IL-5 are found in lung, gut, fat and skin tissues. New findings indicate that ILC2s in different tissues selectively express distinct functional cytokine receptors for cell activation in response to the local environment.

    • Jinfang Zhu
  • News & Views |

    PI3Kδ regulates adaptive immune thresholds and limits immunity to endogenous microbiota.

    • Domenick E. Kennedy
    •  & Marcus R. Clark
  • News & Views |

    Immune responses have the potential to induce life-threatening conditions. A novel multi-system pathway in which neuroendocrine signaling induces expression of the checkpoint receptor PD-1 on NK cells is an important mechanism for protection against cytokine-mediated disease during viral infection.

    • Christine A. Biron
  • News & Views |

    In the current issue of Nature Immunology, Casanova and colleagues demonstrate that humans (and mouse models) with autosomal-recessive SPPL2a deficiency have a severe defect in conventional dendritic cell 2 survival and production of IL-12 and IL-23, and diminished IFN-γ secretion by mycobacterium-specific memory T cells, thus resulting in increased susceptibility to mycobacterial diseases.

    • Sergio D. Rosenzweig
  • News & Views |

    Single-cell transcriptomic analysis shows that B cells experience a continuum of cyclic transitional states during the germinal center (GC) reaction; this pattern is lost in GC-derived follicular lymphoma cells, which seem to be heterogeneous and desynchronized.

    • Katia Basso
  • News & Views |

    Chronic infection with human immunodeficiency virus impairs B cell antigen receptor signaling via a newly described mechanism of inhibitory signaling mediated by IgG3 and the IgG Fc receptor FcRγIIb (CD32b).

    • Amanda E. Agazio
    • , Roberta Pelanda
    •  & Raul M. Torres
  • News & Views |

    T cell activation is ‘digital’: exhaustive single-cell analysis shows that only the proportion of cells that cross the activation threshold is reduced when the affinity of the TCR for its ligand is reduced.

    • Renu Balyan
    • , Joanna Brzostek
    •  & Nicholas R. J. Gascoigne
  • News & Views |

    In response to epithelial DNA damage, tissue-resident γδ T cells initiate and shape a tumor-protective IgE response that requires CD4+ T cells and immune effector cells expressing the high-affinity IgE receptor FcεRI.

    • J. Michael McGraw
    •  & Wendy L. Havran
  • News & Views |

    What keeps memory T cells functionally silent in the absence of infection is unclear. New data reveal the existence of a deterministic halt in the protein-synthesis machinery of memory T cells and expose the discriminatory functions of a family of RNA-binding proteins.

    • Dimitris L. Kontoyiannis
  • News & Views |

    Co-stimulatory second signals delivered through TLRs or CD40 rescue antigen-stimulated B cells from metabolic dysfunction and apoptosis. This identifies a critical time-limited window during which B cells integrate sequential signals to successfully initiate humoral immunity.

    • Tri Giang Phan
    •  & Stuart G. Tangye
  • News & Views |

    Plasmacytoid dendritic cells (pDCs) are type I interferon–producing cells with antigen-presenting potential. pDC populations are composed of transcriptionally and functionally heterogeneous cellular subsets with distinct hematopoietic precursor origin.

    • Markus G. Manz
  • Editorial |

    Autoimmune disease has proven to be a unique conceptual and medical challenge, but hope for effective targeted therapies is tantalizingly close.

  • News & Views |

    The cytokine IL-17F constrains the growth of immunoregulatory Clostridium cluster XIVa species and represents a potential therapeutic target for the treatment of inflammatory bowel disease.

    • Aisling O’Hara Hall
    • , Jennifer E. Towne
    •  & Scott E. Plevy
  • News & Views |

    Tumor-associated natural killer cells have elevated expression of the checkpoint inhibitory receptor TIGIT. Monoclonal antibody–mediated blockade targeting TIGIT unleashes the anti-tumor activity of both natural killer cells and T cells in preclinical mouse models and efficiently delays tumor growth.

    • Ana Stojanovic
    •  & Adelheid Cerwenka
  • News & Views |

    The metabolic master regulator mTORC1 is shown to promote alternative macrophage activation via Semaphorin 6D reverse signaling and reprogramming of lipid metabolism.

    • Jayne Louise Wilson
    •  & Thomas Weichhart
  • News & Views |

    Analysis of whole-blood transcriptional profiles in adults hospitalized with influenza reveals time- and severity-related gene-expression signatures.

    • David F. Tough
  • News & Views |

    Naive T cells migrate rapidly through the lymph node. A high-resolution look at the chemokine receptor CCR7 and integrin LFA-1 reveals that T cells remain highly responsive to their microenvironment via instantaneous tuning of chemokine-regulated actin flow and integrin-regulated adhesion.

    • Patrick W. Oakes
    •  & Deborah J. Fowell