Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Unraveling B cell receptor mechanics

The B cell antigen receptor complex serves as a 'multipurpose machine'. Two new studies provide mechanistic insights into its activation- and anergy-related functions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: BCRs in resting and antigen-stimulated cells.

Katie Ris

References

  1. Nemazee, D. et al. Curr. Top. Microbiol. Immunol. 245, 57–71 (2000).

    CAS  PubMed  Google Scholar 

  2. Kraus, M., Alimzhanov, M.B., Rajewsky, N. & Rajewsky, K. Cell 117, 787–800 (2004).

    Article  CAS  Google Scholar 

  3. Gauld, S.B., Benschop, R.J., Merrell, K.T. & & Cambier, J.C. Nat. Immunol. 6, 1159–1166 (2005).

    Article  Google Scholar 

  4. Tolar, P., Sohn, H.W. & Pierce, S.K. Nat. Immunol. 6, 1167–1175 (2005).

    Article  Google Scholar 

  5. Reth, M. & Wienands, J. Annu. Rev. Immunol. 15, 453–479 (1997).

    Article  CAS  Google Scholar 

  6. Brouns, G.S., de Vries, E. & Borst, J. Int. Immunol. 7, 359–368 (1995).

    Article  CAS  Google Scholar 

  7. Reth, M. Annu. Rev. Immunol. 10, 97–121 (1992).

    Article  CAS  Google Scholar 

  8. Schamel, W.W.A. & Reth, M. Immunity 13, 5–14 (2000).

    Article  CAS  Google Scholar 

  9. Vilen, B.J., Nakamura, T. & Cambier, J.C. Immunity 10, 239–248 (1999).

    Article  CAS  Google Scholar 

  10. Benschop, R.J. et al. Immunity 14, 33–43 (2001).

    Article  CAS  Google Scholar 

  11. Cooke, M.P. et al. J. Exp. Med. 179, 425–438 (1994).

    Article  CAS  Google Scholar 

  12. Healy, J.I. et al. Immunity 6, 419–428 (1997).

    Article  CAS  Google Scholar 

  13. Goodnow, C.C., Brink, R. & Adams, E. Nature 352, 532–536 (1991).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wienands, J. Unraveling B cell receptor mechanics. Nat Immunol 6, 1072–1074 (2005). https://doi.org/10.1038/ni1105-1072

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni1105-1072

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing