Acute ablation of T cell antigen receptors (TCRs) in regulatory T cells (Treg cells) impairs the suppressive activity of these cells, even though they retain expression of Foxp3 and CD25. TCR signaling imparts a critical role in the suppressive function of Treg cells.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Mesenchymal stem cells transfer mitochondria to allogeneic Tregs in an HLA-dependent manner improving their immunosuppressive activity
Nature Communications Open Access 14 February 2022
-
MKL-1 is a coactivator for STAT5b, the regulator of Treg cell development and function
Cell Communication and Signaling Open Access 09 July 2020
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hsieh, C.S., Lee, H.M. & Lio, C.W. Nat. Rev. Immunol. 12, 157–167 (2012).
Kim, J.M., Rasmussen, J.P. & Rudensky, A.Y. Nat. Immunol. 8, 191–197 (2007).
Levine, A.G., Arvey, A., Jin, W. & Rudensky, A.Y. Nat. Immunol. 15, 1070–1078 (2014).
Fontenot, J.D., Rasmussen, J.P., Gavin, M.A. & Rudensky, A.Y. Nat. Immunol. 6, 1142–1151 (2005).
Murphy, T.L., Tussiwand, R. & Murphy, K.M. Nat. Rev. Immunol. 13, 499–509 (2013).
Zheng, Y. et al. Nature 458, 351–356 (2009).
Younes, S.A. et al. PLoS Biol. 9, e1001171 (2011).
Thornton, A.M. & Shevach, E.M. J. Immunol. 164, 183–190 (2000).
Churlaud, G. et al. Clin. Immunol. 151, 114–126 (2014).
Smigiel, K.S. et al. J. Exp. Med. 211, 121–136 (2014).
Tabares, P. et al. Eur. J. Immunol. 44, 1225–1236 (2014).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Zhu, J., Shevach, E. TCR signaling fuels Treg cell suppressor function. Nat Immunol 15, 1002–1003 (2014). https://doi.org/10.1038/ni.3014
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni.3014
This article is cited by
-
Mesenchymal stem cells transfer mitochondria to allogeneic Tregs in an HLA-dependent manner improving their immunosuppressive activity
Nature Communications (2022)
-
MKL-1 is a coactivator for STAT5b, the regulator of Treg cell development and function
Cell Communication and Signaling (2020)
-
Metabolic pressure and the breach of immunological self-tolerance
Nature Immunology (2017)