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  • Focus |

    A comprehensive overview, three review articles and a perspective examine how the innate immunity influences the outcome of the adaptive immune response.

  • Focus |

    Immune surveillance requires constant sampling of cellular peptides by T cells. Here, we present four reviews describing the generation of antigenic peptide epitopes and the cellular enzymes responsible.

  • Focus |

    A comprehensive overview and four review articles that demystify the molecular mechanisms underlying lymphocytes' unique recombination events and specific gene expression programs.

  • Focus |

    This joint web focus with Nature Reviews Immunologyexamines recent inroads into how cell death pathways intersect with the immune system during both development and disease.

  • Focus |

    A series of comprehensive reviews examining mechanisms of immune escape. The juxtaposition of tumor with microbial immune evasion reveals the many parallels between the different systems.

  • Focus |

    The hematopoietic stem cells that reside in our bone marrow might aptly be described as our source of vitality. This focus contains an analysis of progress and news in hematopoietic stem cell research.

  • Focus |

    The mechanisms that cause autoimmune disorders are not fully worked out, in spite of intense effort. This focus thoroughly examines recent clinical and research progress in understanding autoimmunity.

  • Focus |

    Chemokines orchestrate the migration of cells that bear appropriate receptors. Here Nature Immunologychronicles progress in chemokine research, an area that has exploded in the last 10 years.