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Human immunodeficiency virus (HIV) – the etiologic agent of AIDS – is one of the most intensively studied disease organism in history. Since its first identification in the early 1980s, HIV has transformed into a pandemic, globally infecting more 36 million people and annually contributing to the deaths of hundreds of thousands of patients – particularly in low income countries.
Nature Immunology presents a series of five specially commissioned Reviews and Perspectives that discuss the biology of the most important human pathogens today, the characteristics of the immune response and the current strategies to achieve protection through vaccination.
Autoimmunity is an underlying cause of many diseases. This collection of Research, Reviews and News articles from several Nature journals covers the latest advances in genetic and epigenetic research into autoimmunity and autoimmune diseases.
A series of five Reviews specially commissioned by Nature Immunology discuss the genetic, environmental, microbial, and cellular factors underpinning autoimmune disease as well as cover promising avenues for therapeutic intervention.
Five specially commissioned Reviews and Comments discuss the most recent progress in understanding the tissue-specific characteristics of inflammation, the roles of microbiota and nutrition in driving inflammation, and the mechanistic and genetic bases of inflammation resolution and autoinflammation.
Nature Milestones in Antibodies, presented by Nature Immunology, Nature Reviews Immunology, Nature Structural & Molecular Biology and Nature Communications, highlights some of the most influential developments in the history of antibody research.
The nervous and immune systems communicate and reciprocally influence their functional responses. Nature ImmunologyandNature Neurosciencepresent a joint focus entailing a series of specially commissioned review articles that discuss how the nervous system and immune cells interact during development, homeostasis and in pathogenic disease states.
Nature Immunology presents a Focus on recent progress in understanding the ontogeny, functional diversity and activation plasticity of macrophages. Four specially commissioned Reviews and one Perspective discuss the newest insight into the origin and development of macrophages and the regulation of their activation during immune responses, as well as the emerging role of macrophages in tissue homeostasis.
Innate lymphoid cells (ILCs) are a family of lymphoid effector cells with important roles in immunological defense and pathology. Nature Immunology presents a series of specially commissioned articles that discuss the evolution, development, functional diversity and immunotherapeutic potential of ILCs. In collaboration with Nucleus Medical Media, Nature Immunology has also produced an animation that shows the complexity of ILC biology in the gut at steady state and during disease.
Nature Immunologypresents a series of specially commissioned articles that discuss the most recent progress in understanding the immune response to HIV and how this new insight can be harnessed for prophylactic vaccines and immunotherapies.
The lungs are usually the first site of exposure to pathogens. To counter this imminent threat, the lungs have their own large and complex system of cells of the immune system. A series of five Reviews specially commissioned by Nature Immunologydiscusses all key aspects of lung immunology. In collaboration with Arkitek Studios, Nature Immunology has also produced an animation that delineates the complexities of the lung immune system in health and disease. Produced with support from Janssen Pharmaceutical Companies of Johnson & Johnson Animation by Arkitek studios