Articles in 2019

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  • A genome-wide screening of functionally active enhancers, combined with analyses of chromatin features, transcription factor binding and gene expression, reveals general principles of gene regulatory networks in activated B cells.

    • Alexia Martínez de Paz
    • Steven Zvi Josefowicz
    News & Views
  • Singh and colleagues leverage genome-wide assays to identify functionally active enhancers that are present in naive and lipopolysaccharide-activated B cells by FAIRE–seq, STARR–seq and Hi-C structural interactome analyses and identify additional transcription factors that regulate gene expression modules.

    • Virendra K. Chaudhri
    • Krista Dienger-Stambaugh
    • Harinder Singh
  • IL-33, an IL-1 family member, plays dual roles as an intracellular transcription factor and as an extracellular alarmin of tissue damage. Verginis and colleagues identify a cell-intrinsic role for nuclear IL-33 stabilizing Treg cell suppressor function in tumor environments.

    • Aikaterini Hatzioannou
    • Aggelos Banos
    • Panayotis Verginis
  • The International Mouse Phenotyping Consortium (IMPC) aims to identify the function of all protein-coding genes in the mouse genome. Hayday and colleagues leverage 530 knockout lines from the IPMC to develop the 3i Project, which immunophenotypes mice and leads to the identification of new and unexpected gene influences on immune function and on the structural organization of the immune system.

    • Lucie Abeler-Dörner
    • Adam G. Laing
    • Adrian C. Hayday
  • Progress in understanding the rare disease Langerhans cell histiocytosis has stimulated immersive meetings occurring annually over a 30-year period that bring together clinicians, scientists and patients in a unique collaboration.

    • Carl E. Allen
    • Peter C. L. Beverley
    • Astrid van Halteren
  • IL-33 is shown to play a cell-intrinsic role in maintenance of the functional identity of regulatory T cells in the tumor microenvironment. Genetic inhibition of IL-33 potentiates the therapeutic effect of checkpoint inhibitor immunotherapy in a melanoma mouse tumor model.

    • Annelies Demeyer
    • Rudi Beyaert
    News & Views
  • NLRP3-driven sterile inflammation facilitates the pathogenesis of various human inflammatory diseases. New work identifies apolipoprotein C3 as an endogenous NLRP3 agonist that promotes sterile inflammation and organ damage.

    • Tao Gong
    • Rongbin Zhou
    News & Views
  • Hypoxia and acidity in the tumor microenvironment promote resistance to immunotherapy. Hypoxia upregulates multiple immunoinhibitory pathways, including VISTA, and acidity enables VISTA to interact with PSGL-1 to inhibit immune activation selectively in the acidic tumor microenvironment.

    • Kathleen M. Mahoney
    • Gordon J. Freeman
    News & Views